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作品数：321被引量：722H指数：13
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相关机构：中国科学院加拿大多伦多大学第四军医大学滨州医学院更多>>
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Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching
《Neural Regeneration Research》2025年第9期2624-2632,共9页Jangampalli Adi Pradeepkiran Priyanka Rawat Arubala P.Reddy Erika Orlov PHemachandra Reddy 
supported by NIH grants AG079264(to PHR)and AG071560(to APR)。
The process of neurite outgrowth and branching is a crucial aspect of neuronal development and regeneration.Axons and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are use...
关键词：diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule 
Heat acclimation in mice requires preoptic BDNF neurons and postsynaptic potentiation
《Cell Research》2025年第3期224-227,共4页Baoting Chen Cuicui Gao Changhao Liu Tongtong Guo Junwei Hu Jialiang Xue Kangmin Tang Yuelai Chen Tian Yu Qiwei Shen Hongbin Sun Wen Z.Yang Wei L.Shen 
funded by the National Natural Science Foundation of China(92357304,32330042,and 32425028 to W.L.S.;32471076,32100825 to W.Z.Y.;32471205 to H.S.);Shanghai Sailing Program(21YF1429800 to W.Z.Y.);Shanghai Science and Technology Committee of Shanghai City(24ZR1451700 to H.S.);Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine at Shanghai Tech University。
Dear Editor,Heat acclimation(HA)is a key adaptive response in mammals to repeated heat exposure,essential for fitness and survival.1,2 HA improves cardiovascular function,thermal comfort,and exercise capacity.3,4 Howe...
关键词：genetically tractable model brain derived neurotrophic factor medial preoptic area dorsomedial hypothalamus heat acclimation synaptic potentiation rostral raphe pallidus tropomyosin related kinase b 
DTD1 modulates synaptic efficacy by maintaining D-serine and D-aspartate homeostasis
《Science China(Life Sciences)》2025年第2期467-483,共17页Xiao Liu Chaojuan Yang Zhuoran Lin Jianing Li Bin Yin Xuepei Lei Wei Han Boqin Qiang Pengcheng Shu Chen Zhang Xiaozhong Peng 
supported by the National Science and Technology Innovation 2030 Grants of China(2021ZD0200902 to Peng,X.);the National Key Research and Development Program of China(2017YFA0105201 to Zhang,C.);the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(CIFMS;2021-1-I2M-019 to Shu,P.and 2021-1-I2M-024 to Peng,X.);the National Natural Science Foundation of China(31670789 to Peng,X.,32370883 to Shu,P.,81925011 to Zhang,C.,82001145 to Yang,C.);the State Key Laboratory Special Fund 2060204。
D-serine and D-aspartate are involved in N-methyl-D-aspartate receptor(NMDAR)-related physiological and pathological processes.Daminoacyl-t RNA deacylase 1(DTD1)may biochemically contribute to D-serine or D-aspartate ...
关键词：D-aminoacyl-tRNA deacylase 1 D-SERINE D-ASPARTATE synaptic transmission neuronal morphology spatial learning and memory 
Nogo-A Protein Mediates Oxidative Stress and Synaptic Damage Induced by High-Altitude Hypoxia in the Rat Hippocampus
《Biomedical and Environmental Sciences》2025年第1期79-93,共15页Jinyu Fang Huaicun Liu Yanfei Zhang Quancheng Cheng Ziyuan Wang Xuan Fang Huiru Ding Weiguang Zhang Chunhua Chen 
supported by Beijing Natural Science Foundation(No.7232090);the National Natural Science Foundation of China(82101306);the Scientific and Technological Innovation 2030(2021ZD0201100).
Objective High-altitude hypoxia exposure often damages hippocampus-dependent learning and memory.Nogo-A is an important axonal growth inhibitory factor.However,its function in high-altitude hypoxia and its mechanism o...
关键词：NOGO-A NgR1 High-altitude hypoxia Learning and memory Oxidative stress 
Developmental Impairments of Synaptic Refinement in the Thalamus of a Mouse Model of Fragile X Syndrome
《Neuroscience Bulletin》2024年第4期439-450,共12页Xiaotong Wu Yali Liu Xiaomeng Wang Lu Zheng Libiao Pan Hao Wang 
supported by grants from the National Natural Science Foundation of China(32171014,31970940,31671100,31622027);the Zhejiang Provincial Natural Science Foundation of China(LR18H090001);the Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences(2018PT31041);the Program for Introducing Talents in Discipline to Universities,the Fundamental Research Funds for Central Universities(2021FZZX001-37).
While somatosensory over-reactivity is a common feature of autism spectrum disorders such as fragile X syndrome(FXS),the thalamic mechanisms underlying this remain unclear.Here,we found that the developmental eliminat...
关键词：Fragile X syndrome Synaptic refinement VPm Sensory over-reactivity 
A rabies virus-based toolkit for efficient retrograde labeling and monosynaptic tracing被引量：1
《Neural Regeneration Research》2023年第8期1827-1833,共7页Kun-Zhang Lin Lei Li Wen-Yu Ma Xin Yang Zeng-Peng Han Neng-Song Luo Jie Wang Fu-Qiang Xu 
supported by the National Natural Science Foundation of China,Nos.32100899(to KZL),31830035(to FQX),31771156(to FQX),21921004(to FQX);the National Science and Technology Innovation 2030,No.2021ZD0201003(to FQX);the Key-Area Research and Development Program of Guangdong Province,No.2018B030331001(to FQX);the Strategic Priority Research Program of the Chinese Academy of Sciences,No.XDB32030200(to FQX);the Shenzhen Key Laboratory of Viral Vectors for Biomedicine,No.ZDSYS20200811142401005(to FQX)。
Analyzing the structure and function of the brain's neural network is critical for identifying the working principles of the brain and the mechanisms of brain diseases.Recombinant rabies viral vectors allow for the re...
关键词：functional studies neural activity neural circuits projection neurons rAAV9-Retro rabies virus recombination retrograde labeling synaptic inputs trans-monosynaptic tracing 
Advanced synaptic devices and their applications in biomimetic sensory neural system被引量：1
《Chip》2023年第1期1-22,共22页Yiqi Sun Jiean Li Sheng Li Yongchang Jiang Enze Wan Jiahan Zhang Yi Shi Lijia Pan 
This work was supported by the National Key Research and Development Program of China(2021YFA1401103);the National Natu-ral Science Foundation of China(61825403,61921005,and 61674078);the Priority Academic Program Development of Jiangsu Higher Education Insti-tutions.The Postgraduate Research&Innovation Program of Jiangsu Province(KYCX21_0049 to J.-H.Z.).
Human nervous system,which is composed of neuron and synapse networks,is capable of processing information in a plastic,dataparallel,fault-tolerant,and energy-efficient approach.Inspired by the ingenious working mecha...
关键词：Artificial synapse Biomimetic sensory neural system MEMRISTOR Synaptic transistor 
PINK1-mediated Drp1^(S616) phosphorylation modulates synaptic development and plasticity via promoting mitochondrial fission被引量：9
《Signal Transduction and Targeted Therapy》2022年第5期1719-1734,共16页Qingtao Gao Runyi Tian Hailong Han Jesse Slone Caifang Wang Xiao Ke Tongmei Zhang Xiangyu Li Yuhong He Panlin Liao Fang Wang Ye Chen Shiqing Fu Kexuan Zhang Fangfang Zeng Yingxuan Yang Zhuo Li Jieqiong Tan Jiada Li Youming Lu Taosheng Huang Zhonghua Hu Zhuohua Zhang 
This work was supported by the National Natural Science Foundation of China(31730036,81861138012,81161120498,81429002,31330031,82171506,and 31872778);the Discipline Innovative Engineering Plan(111 Program)of China(B13036);a key laboratory grant from Hunan province(2016TP1006);Science and Technology Major Project of Hunan Provincial Science and Technology Department(2018SK1030);the Department of Science and Technology of Hunan Province(grant 2021DK2001,and innovative team program 2019RS1010);The innovative team program from Department of Science&Technology of Hunan Province(2019RS1010);The innovation-driven team project from Central South University(2020CX016),and Hunan 100 Talents Program.
Dynamic change of mitochondrial morphology and distribution along neuronal branches are essential for neural circuitry formation and synaptic efficacy.However,the underlying mechanism remains elusive.We show here that...
关键词：PLASTICITY ACTIVATION SYNAPTIC 
Microglia regulation of synaptic plasticity and learning and memory被引量：40
《Neural Regeneration Research》2022年第4期705-716,共12页Jessica Cornell Shelbi Salinas Hou-Yuan Huang Miou Zhou 
Microglia are the resident macrophages of the central nervous system.Microglia possess varied morphologies and functions.Under normal physiological conditions,microglia mainly exist in a resting state and constantly m...
关键词：AGING Alzheimer's disease cognitive deficits experience-dependent plasticity learning and memory mental disorders MICROGLIA synaptic plasticity synaptic pruning 
Fully rubbery synaptic transistors made out of all-organic materials for elastic neurological electronic skin被引量：4
《Nano Research》2022年第2期758-764,共7页Hyunseok Shim Seonmin Jang Jae Gyu Jang Zhoulyu Rao Jong-ln Hong Kyoseung Sim Cunjiang Yu 
support by the Office of Naval Research grant(N00014-18-1-2338);under Young Investigator Program,the National Science Foundation grants of CAREER(1554499),EFRI(1935291),and CPS(1931893).
Neurologic function implemented soft organic electronic skin holds promise for wide range of applications,such as skin prosthetics,neurorobot,bioelectronics,human-robotic interaction(HRI),etc.Here,we report the develo...
关键词：synaptic transistor STRETCHABLE electronic skin all-organic 
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