SULFONAMIDE

作品数：73被引量：62H指数：4
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相关领域：理学医药卫生更多>>
相关作者：池志宏牛犁王月王占友缪晓玲更多>>
相关机构：西南大学中国医科大学清华大学宁德师范高等专科学校更多>>
相关期刊：《光谱学与光谱分析》《International Journal of Organic Chemistry》《Agricultural Biotechnology》《Journal of Chinese Pharmaceutical Sciences》更多>>
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Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles被引量：2
《Acta Pharmaceutica Sinica B》2023年第6期2747-2764,共18页Shenghua Gao Letian Song Yusen Cheng Fabao Zhao Dongwei Kang Shu Song Mianling Yang Bing Ye Wei Zhao Yajie Tang Erik De Clercq Christophe Pannecouque Peng Zhan Xinyong Liu 
financial support from Natural Science Foundation of China (81974507);Guangdong Basic and Applied Basic Research Foundation (2021A1515110740, China);China Postdoctoral Science Foundation (2021M702003);Shandong Province Natural Science Foundation for Youths (ZR2022QH036, China);the Foundation for Innovative Research Groups of State Key Laboratory of Microbial Technology (WZCX2021-03, China);Foreign cultural and educational experts Project (GXL20200015001, China);Science Foundation for Outstanding Young Scholars of Shandong Province (ZR2020JQ31, China);the Shandong Provincial Key research and development project (2019JZZY021011, China)。
Indolylarylsulfones(IASs) are classical HIV-1 non-nucleoside reverse transcriptase inhibitors(NNRTIs) with a unique scaffold and possess potent antiviral activity.To address the high cytotoxicity and improve safety pr...
关键词：HIV-1 NNRTIS Indolylarylsulfone SULFONAMIDE CYTOTOXICITY 
Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core
《Acta Pharmacologica Sinica》2020年第3期293-302,共10页Jin-tao Wang Yue-ming Zheng Yue-ting Chen Min Gu Zhao-bing Gao Fa-jun Nan 
This work was supported by the National Science Fund for Distinguished Young Scholars(81825021);the National Natural Science Foundation of China(81603096,81773707).
Nav1.7 channels are mainly distributed in the peripheral nervous system.Blockade of Nav1.7 channels with small-molecule inhibitors in humans might provide pain relief without affecting the central nervous system.Based...
关键词：Nav1.7 sodium channel ARYL SULFONAMIDE maprotiline compound lOo ELECTROPHYSIOLOGY acetic acid-induced VISCERAL pain an algesic activity 
GC-NICI-MS analysis of acetazolamide and other sulfonamide (R-SO2-NH2)drugs as pentafluorobenzyl derivatives [R-SO2-N(PFB)2] and quantification of pharmacological acetazolamide in human urine被引量：1
《Journal of Pharmaceutical Analysis》2020年第1期49-59,共11页Olga Begou Kathrin Drabert Georgios Theodoridis Dimitrios Tsikas 
Acetazolamide(molecular mass(MM),222)belongs to the class of sulfonamides(R-SO2-NH2)and is one of the strongest pharmacological inhibitors of carbonic anhydrase activity.Acetazolamide is excreted unchanged in the urin...
关键词：ACETAZOLAMIDE Derivatization Quantification SULFONAMIDES Validation 
Study on the dipeptide vinyl sulfonamide derivatives as proteasome inhibitor
《Journal of Chinese Pharmaceutical Sciences》2016年第6期408-418,共11页姚书扬 周玥 
Natural Science Foundation of China for the financial support(Grant No.30772626)
On the basis of the Michael-addition mechanism of classical proteasome inhibitors, six dipeptide vinyl sulfonamide and dipeptide vinyl sulfonate derivatives were designed and synthesized. Moreover, an efficient method...
关键词：Proteasome inhibitor Dipeptide vinyl sulfonamides Wittig-Horner reaction g-Amino vinyl sulfonamide 
Design, synthesis and biological evaluation of sulfonamide flavone derivatives as potential 20S proteasome inhibitors
《Journal of Chinese Pharmaceutical Sciences》2014年第9期626-630,共5页杨冠宇 孙琦 王超 梁磊 许凤荣 牛彦 徐萍 
The National Natural Science Foundation of China(Grant No.21202003);the National Basic Research Program of China(Grant No.2012CB518000);the Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20120001110010)
A new series of sulfonamide flavone derivatives are designed as non-covalent inhibitors of proteasome assisted with computer-aided drug design （CADD）. The desired compounds were synthesized successfully and the biol...
关键词：Sulfonamide flavone derivatives Non-covalent inhibitor CADD 20S proteasome inhibitor SELECTIVITY 
Sulfonyl Imidazoles as Reagents for the Preparation of Sulfonates and Sulfonamides
《Chemical Research in Chinese Universities》2008年第1期54-57,共4页REN Yu-jie GUI Bin WU Hai-xia SUN Xiao-bin 
Several new sulfonates and sulfonamides were synthesized with sulfonyl imidazoles as reagents. These compounds were characterized by ^1H NMR. The melting points of all solids synthesized were obtained on Fisher-Johns ...
关键词：Sulfonyl imidazole SULFONATE SULFONAMIDE Synthesis 
Design, Synthesis, and Activities of Novel Derivativesof Isophthalamide and Benzene-1,3-disulfonamide被引量：7
《Chemical Research in Chinese Universities》2006年第3期356-359,共4页LIU Xiu-jie WANG Song-qing ZHANG jing ZHANG Feng-xia LI Gui-zhu WANG Bao-jie SHAO Ying-lu ZHANG Li-guang FANG Lin CHENG Mao-sheng 
Based on the antiplatelet aggregation mechanism and the bioisosterism principle of the reference drug picotamide, thirteen novel derivatives of arylamide and arylsulfonamide were designed and prepared. The biological ...
关键词：THROMBOXANE ANTIPLATELET Isophthalamide Disulfonamide SYNTHESIS 
Design, synthesis and bioactivity of novel ALS inhibitors (V)——Initial model of the herbicidal sulfonylureas and fused heterocyclic sulfonamides binding with receptor被引量：2
《Science China Chemistry》1998年第4期353-360,共8页杨光富 赵国锋 陆荣健 刘华银 杨华铮 
theNationalNaturalScienceFoundationofChina (GrantNo .2 94 72 0 5 6 )
By means of the X\|ray diffraction method, quantum pharmacology analysis and quantitative structure\|activity relationships (QSAR) analysis, the structure\|activity relationships of the herbicidal sulfonylureas and fu...
关键词：SULFONYLUREA FUSED HETEROCYCLIC SULFONAMIDE X\|ray diffraction quantum pharmacology QSAR ALS. 
Preparation of polyethylene oxide with 4-amino-N-(2-pyrimidinyl) benzene sulfonamide and diethylenetriaminepentaacetic acid end groups and its enrichment in tumour tissues被引量：1
《Science China Chemistry》1998年第1期54-59,共6页黄骏廉 陈胜 谈立松 王海原 
ProjectsupportedbytheNationalNaturalScienceFoundationofChina DoctorTrainingFoundationoftheStateEducationCommissionofChinaandtheNaturalScienceFoundationofShanghai
Using polyethylene oxide (PEO) with 4 amino N (2 pyrimidinyl) benzene sulfonamide (APBS) and hydroxyl end groups (PEO a h ) as parent compounds, PEO with diethylenetriaminepentaacetic acid (DTPA) and APBS end groups (...
关键词：polyethylene oxide 4-amino-N-(2-pyrimidinyl) benzene sulfonamide diethylenetriaminepentaacetic acid anti-turnour drug directing function 
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