CANCERS

作品数：353被引量：2621H指数：17
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相关领域：医药卫生生物学更多>>
相关作者：夏厚军陈策实徐留柱刘端祺介雅慧更多>>
相关机构：中南大学南京医科大学教育部中国科学院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金福建省自然科学基金更多>>
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A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers被引量：5
《Cell Research》2023年第1期30-45,共16页Rongjie Cheng Fanying Li Maolei Zhang Xin Xia Jianzhuang Wu Xinya Gao Huangkai Zhou Zhi Zhang Nunu Huang Xuesong Yang Yaliang Zhang Shunli Shen Tiebang Kang Zexian Liu Feizhe Xiao Hongwei Yao Jianbo Xu Chao Yan Nu Zhang 
This work was jointly supported by the National Natural Science Distinguished Youth Foundation of China(82125024 to N.Z.);the National Natural Science Outstanding Youth Foundation of China(81822033 to N.Z.);the National Key R&D Program of China(2016YFA0503000 to N.Z.and 2020YFA0713800 to C.Y.);the National Natural Science Foundation of China(81772683 to N.Z.,21877060 to C.Y.,81871915 to J.X.,and 31870735 to H.Y.).
Mutations of the RAS oncogene are found in around 30%of all human cancers yet direct targeting of RAS is still considered clinically impractical except for the KRAS^(G12C)mutant.Here we report that RAS-ON(RASON),a nov...
关键词：KRAS CRISPR/Cas9 CANCERS 
RASON,a new player in cancer’s Premier League
《Cell Research》2023年第1期1-2,共2页Sara Mainardi Rene Bernards 
Mutations in the KRAS oncogene drive proliferation of 30%of all human cancers,for which effective targeted therapies are still urgently needed.In a recent study published in Cell Research,Cheng et al.report the identi...
关键词：KRAS STRATEGIES 
Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers被引量：6
《Cell Research》2019年第10期832-845,共14页Daisong Wang Xin Hu Chunye Liu Yingying Jia Yiqin Bai Cheguo Cai Jingqiang Wang Lanyue Bai Ruikai Yang ChangDong Lin Yi-Rong Liu Shan Li Feng Qiao Ling Yao Li Chen Gaoxiang Ge Hai Jiang Dianfan Li Lin Li JianFeng Chen Zhi-Ming Shao Yi Arial Zeng 
grants from National Natural Science Foundation of China(31830056,31861163006,31625020,31530045,31661143043 to Y.A.Z,81874113 to Z.-M.S;81672601,81872137 to X.H.);Chinese Academy of Sciences(XDA12020378 to Y J.and XDB19000000 to Y.A.Z.);Shanghai Municipal Science and Technology Commission(17XD1404000 to Y.A.Z.)and National Ten Thousand Talents Program(to Y.A.Z.).
Breast cancer is a heterogeneous disease.In particular,triple-negative breast cancer(TNBC)comprises various molecular subgroups with unclear identities and currently has few targeted treatment options.Our previous stu...
关键词：BREAST CANCERS treatment 
How cancers usurp macrophages to keep growing
《Cell Research》2019年第6期423-424,共2页Olmo Sonzogni Gerburg M. Wulf 
Liu et al. report the direct interaction of tumor-associated macrophages with cancer stem cells (CSC) through specific ligand-receptor binding (LSECtin-BTN3A3), and how targeting this receptor-ligand interaction decim...
关键词：REPORT cancer CELLS 
RNA N^6-methyladenosine modification in cancers： current status and perspectives被引量：71
《Cell Research》2018年第5期507-517,共11页Xiaolan Deng Rui Su Hengyou Weng Huilin Huang Zejuan Li Jianjun Chen 
This work was supported in part by a grant （No. 81603149 to X,D.） from National Nature Science Foundation of China, as well as the National Institutes of Health （NIH） R01 Grants CA214965 （J.C.）, CA211614 （J.C.）, and CA178454 （J.C.）. Z.L. is supported by an American Cancer Society （ACS） Research Scholar Award. J.C. is a Leukemia ＆ Lymphorna Society （LLS） Scholar.
N^6-methyladenosine （m^6A）, the most abundant internal modification in eukaryotic messenger RNAs （mRNAs）, has been shown to play critical roles in various normal bioprocesses such as tissue development, stem cell ...
关键词：RNA 癌症 真核细胞 生物功能 蛋白质 治疗学 干细胞 DNA 
Modeling sarcomagenesis using multipotent mesenchymal stem cells被引量：9
《Cell Research》2012年第1期62-77,共16页Rene Rodriguez Ruth Rubio Pablo Menendez 
Because of their unique properties, multipotent mesenchymal stem cells （MSCs） represent one of the most prom- ising adult stem cells being used worldwide in a wide array of clinical applications. Overall, compelling...
关键词：multipotent mesenchymal stem cells adipose-derived stem cell SARCOMA sarcoma models fusion genes cancerstem cell sarcoma-initiating cell 
Characterization of microRNAs in serum： a novel class of biomarkers for diagnosis of cancer and other diseases被引量：992
《Cell Research》2008年第10期997-1006,共10页Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang 
Acknowledgments We thank Drs Fengyong Liu and Sheng Luan at UC Berkeley, USA, for their discussion and help with the writing of the manuscript. This work was supported by grants from the National Natural Science Foundation of China （no. 30225037, 30471991, 30570731）, National Basic Research Program of China （973 Program） （no. 2006CB503909, 2004CB518603）, the ＂111＂ Project, and the Natural Science Foundation of Jiangsu Province （no. BK2004082, BK2006714）.
Dysregulated expression of microRNAs （miRNAs） in various tissues has been associated with a variety of diseases, including cancers. Here we demonstrate that miRNAs are present in the serum and plasma of humans and o...
关键词：serum-microRNA expression profile FINGERPRINT blood-based biomarker Solexa CANCERS diabetes 
N-Myc downstream-regulated gene 2 (NDRG2) is a negative regulator of cell growth and its expression is decreased in cancers
《Cell Research》2002年第3期293-293,共1页
Using subtraction cloning, we identified the human N-Myc Downstream- Regulated Gene-2 (hNDRG2), located at 14q11.2, as a candidate tumor suppressor gene. Semi-quantitative RT-PCR showed that the expression of hNDRG2 i...
关键词：N-Myc减量调节基因2 NDRG2 细胞生长 负向调节 癌症 表达减少 
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