In this editorial,we comment on the article by Zhao et al which highlighted how patients having nonalcoholic fatty liver disease(NAFLD)were more susceptible to drug-induced lung injury(DILI).This article looked at the...
Rationale:Opioids,the class of drugs,frequently used for pain relief in acute pancreatitis are known to act as a dual-edged sword.They are capable of causing acute pancreatitis though very rare.Patient’s Concern:A 45...
In a recent publication in Cell,a multidisciplinary academic drug discovery team,with its spin-off HepaRegeniX,published a first-in-class small molecule MKK4 inhibitor(HRX215)with remarkable efficacy in multiple precl...
BACKGROUND Interleukin-17(IL-17)inhibitors are known to cause exacerbation or new onset of inflammatory bowel disease upon administration.However,few reports have described characteristic endoscopic and histopathologi...
This project was supported by grants from the National Science and Technology Major Project(No.2014ZX10005001 and No.2018ZX10302204-001);Chen Xiaoping Development Foundation(No.CXPJJH12000002-2020032).
Objective Little is known about the role of microRNA-29a-3p(miR-29a-3p)in inflammation-related pyroptosis,especially in drug-induced acute liver failure(DIALF).This study aimed to identify the relationship between miR...
BACKGROUND Empirical use of potentially hepatotoxic drugs in the management of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection is considered as one of the major etiopathogenetic factors for liver ...
Drug-induced autoimmune hepatitis(DIAIH)is a specific phenotype of druginduced liver injury that may lead to the devastating outcome of acute liver failure requiring liver transplantation.Drugs implicated in DIAIH inc...
The study was funded by a grant from Croatian Ministry of Science and Education(dedicated to multi-year institutional funding of scientific activity at the J.J.Strossmayer University of Osijek,Osijek,Croatia,under grant number:IP10-MEFOS-2019 to MS);Support from the Herman Lopata Chair in Hepatitis Research is also gratefully acknowledged(to GYW).
Metabolic dysfunction-associated fatty liver disease(commonly known as MAFLD)impacts global health in epidemic proportions,and the resulting morbidity,mortality and economic burden is enormous.While much attention has...
Supported by Italian Ministry of Health(IRCCS Burlo Garofolo),No.RC 7_2014.
Drug-induced pancreatitis is a gastrointestinal adverse effect concerning about 2%of drugs.The majority of cases are mild to moderate but severe episodes can also occur,leading to hospitalization or even death.Unfortu...