AGE-RELATED

作品数:152被引量:373H指数:10
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相关领域:医药卫生更多>>
相关作者:陈梅梅颜奕熊浩谢立科王楠更多>>
相关机构:首都医科大学西安外国语大学北京语言大学中国中医科学院眼科医院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划湖北省自然科学基金广东省自然科学基金更多>>
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Targeting NAD Metabolism for the Therapy of Age-Related Neurodegenerative Diseases
《Neuroscience Bulletin》2024年第2期218-240,共23页Feifei Li Chou Wu Gelin Wang 
supported by the National Natural Science Foundation of China(91949101 and 81872874);the Tsinghua-Peking Center for Life Sciences,the Beijing Advanced Innovation Center for Structural Biology,the Tsinghua-Toyota Joint Research Fund,and the Tsinghua University Initiative Scientific Research Program.
As the aging population continues to grow rapidly, age-related diseases are becoming an increasing burden on the healthcare system and a major concern for the well-being of elderly individuals. While aging is an inevi...
关键词:Ageing NEUROPROTECTION NAD metabolism Therapeutic strategy Neurodegenerative diseases 
Age-Related Reduction in Cortical Thickness in First-Episode Treatment-Na?ve Patients with Schizophrenia被引量:5
《Neuroscience Bulletin》2019年第4期688-696,共9页Yin Lin Mingli Li Yi Zhou Wei Deng Xiaohong Ma Qiang Wang Wanjun Guo Yinfei Li Lijun Jiang Xun Hu Nanyin Zhang Tao Li 
supported by the National Basic Research Development Program of China (2016YFC0904300);National Natural Science Foundation of China (81630030, 81130024 and 81528008);the National Natural Science Foundation of China/Research Grants Council of Hong Kong Joint Research Scheme (81461168029);the ‘‘135’’ Project for Disciplines of Excellence, West China Hospital of Sichuan University, China (ZY2016103 and ZY2016203)
Substantial evidence supports the neurodevelopmental hypothesis of schizophrenia.Meanwhile,progressive neurodegenerative processes have also been reported,leading to the hypothesis that neurodegeneration is a characte...
关键词:SCHIZOPHRENIA CORTICAL thickness AGE-RELATED 
Phosphorylated TDP-43 Staging of Primary Age-Related Tauopathy被引量:5
《Neuroscience Bulletin》2019年第2期183-192,共10页Xiaoling Zhang Bing Sun Xing Wang Hui Lu Fangjie Shao Annemieke J.M.Rozemuller Huazheng Liang Chong Liu Jiadong Chen Manli Huang Keqing Zhu 
supported by the National Science Foundation China(91632109 to JHZ,KQZ and HJH);the Zhejiang Provincial Natural Science Foundation(LY16H090013 to KQZ);the Zhejiang Medical and Health Science and Technology Plan Project(WKJ20132-009 to KQZ)
Primary age-related tauopathy(PART) is characterized by tau neurofibrillary tangles(NFTs) in the absence of amyloid plaque pathology. In the present study,we analyzed the distribution patterns of phosphorylated43-kDa ...
关键词:TDP-43 Primary age-related tauopathy Alzheimer's disease Neurofibrillary tangle HIPPOCAMPUS 
Cuprizone-induced demyelination in mice: age-related vulner-ability and exploratory behavior deficit被引量:4
《Neuroscience Bulletin》2013年第2期251-259,共9页Hongkai Wang Chengren Li Hanzhi Wang Feng Mei Zhi Liu Hai-Ying Shen Lan Xiao 
supported by the National Natural Science Foundation of China (81071084);the International Science &Technology Cooperation Program of China (2010DFB30820);the Natural Science Foundation of Chongqing Municipality, China(2010DBF30820)
Schizophrenia is a mental disease that mainly affects young individuals (15 to 35 years old) but its etiology remains largely undefined. Recently, accumulating evidence indicated that demyelination and/or dysfunctio...
关键词:SCHIZOPHRENIA OLIGODENDROCYTES agedemyelination CUPRIZONE 
Age-related effects of estrogen on the expression of estrogen receptor (ER) α and β mRNA in the ovariectomized (OVX) monkey hypothalamus被引量:1
《Neuroscience Bulletin》2006年第2期97-102,共6页Jian-Zhong BAO Can-Rong NI Wei-Qiang ZHENG 
In the present study, we reported distribution of ERα and ER β mRNAs in the hypothalamus of young and old ovariectomized (OVX) rhesus macaques. The ERα were detected in all six major vestiblular nuclei which incl...
关键词:estrogen receptor MRNA HYPOTHALAMUS Rhesus Macaque 
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