supported by the National Natural Science Foundation of China(91949101 and 81872874);the Tsinghua-Peking Center for Life Sciences,the Beijing Advanced Innovation Center for Structural Biology,the Tsinghua-Toyota Joint Research Fund,and the Tsinghua University Initiative Scientific Research Program.
As the aging population continues to grow rapidly, age-related diseases are becoming an increasing burden on the healthcare system and a major concern for the well-being of elderly individuals. While aging is an inevi...
supported by the National Basic Research Development Program of China (2016YFC0904300);National Natural Science Foundation of China (81630030, 81130024 and 81528008);the National Natural Science Foundation of China/Research Grants Council of Hong Kong Joint Research Scheme (81461168029);the ‘‘135’’ Project for Disciplines of Excellence, West China Hospital of Sichuan University, China (ZY2016103 and ZY2016203)
Substantial evidence supports the neurodevelopmental hypothesis of schizophrenia.Meanwhile,progressive neurodegenerative processes have also been reported,leading to the hypothesis that neurodegeneration is a characte...
supported by the National Science Foundation China(91632109 to JHZ,KQZ and HJH);the Zhejiang Provincial Natural Science Foundation(LY16H090013 to KQZ);the Zhejiang Medical and Health Science and Technology Plan Project(WKJ20132-009 to KQZ)
Primary age-related tauopathy(PART) is characterized by tau neurofibrillary tangles(NFTs) in the absence of amyloid plaque pathology. In the present study,we analyzed the distribution patterns of phosphorylated43-kDa ...
supported by the National Natural Science Foundation of China (81071084);the International Science &Technology Cooperation Program of China (2010DFB30820);the Natural Science Foundation of Chongqing Municipality, China(2010DBF30820)
Schizophrenia is a mental disease that mainly affects young individuals (15 to 35 years old) but its etiology remains largely undefined. Recently, accumulating evidence indicated that demyelination and/or dysfunctio...
In the present study, we reported distribution of ERα and ER β mRNAs in the hypothalamus of young and old ovariectomized (OVX) rhesus macaques. The ERα were detected in all six major vestiblular nuclei which incl...