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CUPRIZONE: 作品数：33被引量：73H指数：4; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：马坚妹范凯宋大为李林尹琳琳更多>>; 相关机构：第三军医大学大连医科大学首都医科大学宣武医院重庆医科大学更多>>; 相关期刊：《磁共振成像》《Neural Regeneration Research》《中国药理通讯》《解剖学杂志》更多>>; 相关基金：国家自然科学基金重庆市自然科学基金山西省省筹资金资助回国留学人员科研项目辽宁省科技厅博士启动基金更多>>

Role of copper in central nervous system physiology and pathology: 《Neural Regeneration Research》2025年第4期1058-1068,共11页Martina Locatelli Cinthia Farina; Copper is a transition metal and an essential element for the organism,as alterations in its homeostasis leading to metal accumulation or deficiency have pathological effects in several organs,including the central ne...; 关键词：ASTROCYTES central nervous system COPPER CUPRIZONE multiple sclerosis MYELIN neurodegenerative disorders

Olig2^(+) single-colony-derived cranial bone-marrow mesenchymal stem cells achieve improved regeneration in a cuprizone-induced demyelination mouse model: 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第12期1108-1114,共7页Deqing PENG Ruijie LU Leyao LÜ Qing YAO Kaichuang YANG Yunfeng XU Xiaoming FENG Ruolang PAN Yuyuan MA; supported by the Zhejiang Provincial Nat ural Science Foundation of China(Nos.LQ21H090016 and LTGY23H090016)。; Oligodendrocytes are the myelinating cells of the central nervous system.Brain injury and neurodegenerative disease often lead to oligodendrocyte death and subsequent demyelination-related pathological changes,resulti...; 关键词：MYELIN Olig2^(+)

CDP-choline to promote remyelination in multiple sclerosis:the need for a clinical trial被引量：3: 《Neural Regeneration Research》2023年第12期2599-2605,共7页Viktoria Gudi PawełGrieb Ralf ALinker Thomas Skripuletz; Multiple sclerosis is a multifactorial chronic inflammatory disease of the central nervous system that leads to demyelination and neuronal cell death,resulting in functional disability.Remyelination is the natural rep...; 关键词：ASTROCYTES CDP-CHOLINE CUPRIZONE microglia multiple sclerosis OLIGODENDROCYTES

Cuprizone诱导的多发性硬化疾病动物模型的特点及应用被引量：1: 《中国比较医学杂志》2023年第9期132-137,共6页李琳王异民王伟王珊盘美良孙伟强樊卫平石建云; 山西省应用基础研究计划青年科技研究基金(201901D211321);山西省教育厅高校科技创新计划(2020L0184)。; 多发性硬化(Multiple sclerosis,MS)是以人类中枢神经系统炎性脱髓鞘为主要特点的神经退行性疾病,并伴随着轴突损伤、胶质细胞增生、炎性细胞浸润等病理特征。双环己酮草酰二腙(Cuprizone,CPZ)是一种铜离子螯合剂,给小鼠饲喂CPZ可诱导...; 关键词：多发性硬化 CUPRIZONE 神经胶质细胞脱髓鞘髓鞘再生特色疗法

Microglia depletion as a therapeutic strategy:friend or foe in multiple sclerosis models?被引量：5: 《Neural Regeneration Research》2023年第2期267-272,共6页Victoria Sofia Berenice Wies Mancini Anabella Ayelen Di Pietro Laura Andrea Pasquini; M ultiple sclerosis is a chro nic central nervous system demyelinating disease whose onset and progression are driven by a combination of immune dysregulation,genetic predisposition,and environmental fa ctors.The acti...; 关键词：ASTROCYTES colony-stimulating factor-1 receptor inhibition CUPRIZONE demyelnation MICROGLIA multiple sclerosis NEURODEGENERATION

复合益生菌制剂缓解cuprizone诱导的小鼠神经脱髓鞘被引量：1: 《微生物学报》2022年第3期774-784,共11页杨昊李琳刘青青康行杨晓丹刘海霞樊卫平; 山西省省筹资金资助回国留学人员科研项目(2020-079);山西省应用基础研究面上青年基金(201901D211321)。; 【目的】探索复合益生菌制剂对双环己酮草酰二腙(cuprizone,CPZ)诱导的小鼠脑内神经脱髓鞘的作用。【方法】将27只小鼠随机分为正常组(NC)、模型组(CPZ)和益生菌处理组(probiotics)。NC组小鼠正常饲喂,CPZ组和probiotics组小鼠饲喂含0.2...; 关键词：双环己酮草酰二腙多发性硬化症(MS) 脱髓鞘益生菌肠屏障

Rg1 exerts protective effect in CPZ-induced demyelination mouse model via inhibiting CXCL10-mediated glial response被引量：3: 《Acta Pharmacologica Sinica》2022年第3期563-576,共14页Yi-xiao Dong Shi-feng Chu Sha-sha Wang Ya-juan Tian Wen-bin He Yu-sheng Du Zhen-zhen Wang Xu Yan Zhao Zhang Nai-hong Chen; This work was supported by the National Natural Science Foundation of China(81973499,81873026,81730096,82074044,81773924,and 81960729);the CAMS Innovation Fund for Medical Sciences(CIFMS)(2016-I2M-1-004);the Opening Program of the Shanxi Key Laboratory of Chinese Medicine Encephalopathy(CME-OP-2017001);the High-End Foreign Experts Introduction Program(G20200001485).; Myelin damage and abnormal remyelination processes lead to central nervous system dysfunction.Glial activation-induced microenvironment changes are characteristic features of the diseases with myelin abnormalities.We ...; 关键词：DEMYELINATION ginsenoside Rg1 CUPRIZONE glial response CXCL10

Ferroptosis:copper-iron connection in cuprizone-induced demyelination被引量：2: 《Neural Regeneration Research》2022年第1期89-90,共2页Priya Jhelum Samuel David; supported by a grant from the Canadian Institutes of Health Research(CIHR)(MOP-142231);MS Society of Canada(MSSOC)(to SD);MSSOC postdoctoral fellowship(to PJ)。; Redox active metals such as iron,copper,zinc,and manganese play important roles in promoting a variety of biochemical reactions essential for cellular function.This is made possible by the ability of these metals to a...; 关键词：function. COPPER METALS

淫羊藿苷对cuprizone诱导精神分裂症样小鼠模型行为学变化、髓鞘脱失及神经炎性反应的影响被引量：4: 《首都医科大学学报》2021年第5期761-767,共7页陈溪马登磊李林; 国家自然科学基金(81673406);首都医科大学科研培育项目(PYZ19134);北京市科协青年人才托举计划(2020-2022);北京市金桥种子工程项目(Z191100006119017)。; 目的应用双环己酮草酰二腙(cuprizone)诱导的精神分裂症样小鼠模型,研究淫羊藿苷(icariin,ICA)对模型小鼠行为学变化、髓鞘脱失及神经炎性反应的影响。方法用含0.2%(质量分数)cuprizone的饲料饲喂C57BL/6小鼠5周,制备脱髓鞘模型。造模...; 关键词：淫羊藿苷精神分裂症双环己酮草酰二腙髓鞘脱失神经炎性反应

银杏内酯B口服对cuprizone诱导的脱髓鞘小鼠的髓鞘保护被引量：2: 《中国神经免疫学和神经病学杂志》2021年第5期386-391,共6页俞明杨赵梦茹田童张倩霞张雨萌杨颖博肖保国肖伟; 国家重点研发计划资助项目(2019YFC1711000)。; 目的探讨口服银杏内酯B(GB)对双环己酮草酰二腙(cuprizone,CPZ)诱导的脱髓鞘小鼠的保护作用。方法选择C57BL/6雄性小鼠24只,随机将小鼠分为正常组、CPZ模型组和GB干预组,每组8只。采用连续喂食6周含0.2%(质量分数)CPZ的饲料方法制备脱...; 关键词：银杏内酯双环己酮草酰二腙脱髓鞘疾病小胶质细胞神经炎症

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