NEUTRALIZING

作品数：88被引量：189H指数：6
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相关作者：郝荣宽杜桂枝闻仲权阎淑琴章晓联更多>>
相关机构：卫生部北京生物制品研究所武汉大学中国科学院上海生命科学研究院更多>>
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IL2-mediated modulation of small extracellular vesicles secretion and PD-L1 expression: a novel perspective for neutralizing immune suppression within cancer cells
《Cancer Communications》2024年第12期1422-1426,共5页Soojeong Noh Suyeon Ryu Dokyung Jung Sanghee Shin Inseong Jung Sung-Min Kang Christine Seulki Kim Sung-Jin Choi Hanchae Cho Melanie Schwammle Youngtae Jeong Felicitas Bucher Il-Kyu Choi Shin Yup Lee Sin-Hyeog Im Kyungmoo Yea Moon-Chang Baek 
supported by the Bio&Medical Technology Development Program of the National Research Foundation(NRF)of Korea funded by the Korean government(MSIT)(2022R1A2C109214511 and 2020M3A9I4039539);the National Research Foundation of Korea(NRF)grant funded by the Korean government(MSIT)(2021R1A5A2021614,2023R1A2C3005553);the DGIST Program of the Ministry of Science and ICT(21-DGRIP-01).
Cancer cells secrete small extracellular vesicles(sEVs)to regulate various cellular functions,like tumor growth and metastasis,by promoting epithelial-mesenchymal transition and angiogenesis[1,2].Additionally,cancer c...
关键词：PDL1 CANCER CANCER 
Reduced neutralizing antibody production against Omicron XBB.1.5 in people living with HIV
《Chinese Medical Journal》2024年第21期2633-2635,共3页Jiaying Zhang Jiming Yin Wenjing Wang Juanli Gao Tongzeng Li Danlei Mou Lianchun Liang Qinghua Meng Yingmei Feng 
supported by a grant from the National Key R&D Program of China(No.2023YFC0872400).
To the Editor:The emergence of Omicron has gained global attention since November 2021.Of the Omicron strains,Omicron XBB.1.5 is the most recently identified.It carries deletions and more than 30 mutations,which have ...
关键词：capacity gained NEUTRAL 
Robust neutralizing antibody response to the XBB.1.5 trivalent recombinant protein vaccine booster
《Signal Transduction and Targeted Therapy》2024年第9期3560-3562,共3页Bing-Dong Zhan Xue-Dong Song Xin Yu Guo-Jian Yang Sheng Wan Mai-Juan Ma 
supported by grants from the National Natural Science Foundation of China(82273692 and 92169207);the Quzhou Science and Technology Bureau(2021K12)。
Dear Editor,The global prevalence of XBB subvariants,known for their significant immune evasion,has driven the development and adaptation of XBB vaccines.Monovalent XBB.1.5 mRNA vaccines have been developed and shown ...
关键词：valent NEUTRAL BREAKTHROUGH 
Intranasal adenovirus-vectored Omicron vaccine induced nasal immunoglobulin A has superior neutralizing potency than serum antibodies
《Signal Transduction and Targeted Therapy》2024年第8期3507-3518,共12页Si Chen Zhengyuan Zhang Qian Wang Qi Yang Li Yin Lishan Ning Zhilong Chen Jielin Tang Weiqi Deng Ping He Hengchun Li Linjing Shi yjun Deng Zijian Liu Hemeng Bu Yaohui Zhu Wenming Liu Linbing Qu Ligiang Feng Xiaoli Xiong Baoqing Sun Nanshan Zhong Feng Li ingchao Li Xinwen Chen Ling Chen 
The study was supported by the National Natural Science Foundation(92269201);Youth Innovation Promotion Association of CAS(2022361);Grants from Guangzhou National Laboratory(GZNL2024A01012,GZNL2023A01009);State Key Laboratory of Respiratory Disease(SKLRD-Z-202106,SKLRD-Z-202328);Science and Technology Projects in Guangzhou(SL2022A04J00604).
The upper respiratory tract is the initial site of SARS-CoV-2 infection.Nasal spike-specific secretory immunoglobulin A(slgA)correlates with protection against Omicron breakthrough infection.We report that intranasal ...
关键词：NASAL ANTIBODIES neutral 
Regression of choroidal neovascularization often precedes macular atrophy in eyes with neovascular age-related macular degeneration treated with vascular endothelial growth factor neutralizing proteins
《Eye Science》2024年第4期259-275,共17页Saleema Kherani Roomasa Channa Adrienne W.Scott James T.Handa Akrit Sodhi Adam S.Wenick Ingrid Zimmer-Galler Sharon D.Solomon Peter Gehlbach Mira M.Sachdeva Becky S.Sama Anam Akhlaq Olukemi Adeyemo Mustafa Iftikhar Peter A.Campochiaro 
supported by an unrestricted grant from Research to Prevent Blindness,New York,NY.
Aims:To identify incident macular atrophy and evaluate antecedent anatomic alterations in eyes with neovascular age-related macular degeneration(NVAMD)that were treated with anti-vascular endothelial growth factor(ant...
关键词：macular atrophy wet AMD neovascular AMD ANTI-VEGF 
Passive antibody therapy in emerging infectious diseases
《Frontiers of Medicine》2023年第6期1117-1134,共18页Xiaoming Yang 
The epidemic of corona virus disease 2019(COVID-19)caused by severe acute respiratory syndrome Coronavirus 2 and its variants of concern(VOCs)has been ongoing for over 3 years.Antibody therapies encompassing convalesc...
关键词：SARS-CoV-2 COVID-19 convalescent plasma hyperimmunoglobulin neutralizing monoclonal antibodies 
STING and TLR9 agonists synergistically enhance the immunogenicity of SARS-CoV-2 subunit vaccine被引量：1
《Nano Research》2023年第12期13322-13334,共13页Yang Li Ziwei Chen Xinyi Lu Jiufeng Sun Mengyu Guo Huige Zhou Ru Bai Yuliang Zhao Chunying Chen Yaling Wang 
supported by the National Basic Research Program of China(Nos.2022YFA1603701 and 2021YFA1200900);Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB36000000);the National Natural Science Foundation of China(Nos.82341044 and 22027810);CAMS Innovation Fund for Medical Sciences(No.CIFMS 2019-I2M-5-018).
Vaccines that are reliable and efficacious are essential in the fight against the COVID-19 pandemic.In this study,we designed a dual-adjuvant system with two pathogen-associated molecular patterns(PAMPs),MnOx and CpG....
关键词：dual-adjuvant system synergistic immune activation antigen dosage reducing variants neutralizing 
Neutralizing Antibody Responses against Five SARS-CoV-2 Variants and T Lymphocyte Change after Vaccine Breakthrough Infections from the SARS-CoV-2 Omicron BA.1 Variant in Tianjin, China: A Prospective Study
《Biomedical and Environmental Sciences》2023年第7期614-624,共11页ZHANG Ying QU Jiang Wen ZHENG Min Na DING Ya Xing CHEN Wei YE Shao Dong LI Xiao Yan LI Yan Kun LIU Ying ZHU Di JIN Can Rui WANG LIN YANG Jin Ye ZHAI Yu WANG Er Qiang MENG Xing 
funded by the Emergency prevention and cure Program of COVID-19[22ZXGBSY00010];Tianjin Medical Key Discipline Project[TJYXZDXK-50A];sponsored by Tianjin Municipal Science and Technology Bureau and Tianjin Municipal Health Commission,respectively.
Objective To investigate whether Omicron BA.1 breakthrough infection after receiving the SARS-CoV-2 vaccine could create a strong immunity barrier.Methods Blood samples were collected at two different time points from...
关键词：SARS-CoV-2 COVID-19 Omicron BA.1 T cells Neutralizing antibodies 
Two human monoclonal SARS-CoV-2 antibodies that maintain neutralizing potency against the SARS-CoV-2 Omicron BA.1 and BA.2 variants
《Genes & Diseases》2023年第3期664-667,共4页Qianqian Zheng Liangwei Duan Zhihua Jiang Tingxuan Gu Bojie Zhang Jiaoyang Li Yang Zhang Shiyu Zhang Yinming Liang Hui Wang 
supported by The National Natural Science Foundation of China(No.81871312);the Key Scientific and Technological Project of Henan Province(No.222102310025);The International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan(KFKTYB202210);the 111 Project(No.D20036).
The pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continues to sweep the globe with devastating consequences on human lives and world economy.As an RNA virus,SARS-CoV-2 has a relatively...
关键词：acute MONOCLONAL respiratory 
Broad strategies for neutralizing SARS-CoV-2 and other human coronaviruses with monoclonal antibodies被引量：2
《Science China(Life Sciences)》2023年第4期658-678,共21页Zhiyang Ling Chunyan Yi Xiaoyu Sun Zhuo Yang Bing Sun 
supported by grants from the Ministry of Science and Technology of China(2018YFA0507402);the Key International Partnership Program of the Chinese Academy of Sciences(153D31KYSB20180055);the National Natural Science Foundation of China(32270991,32100123,32100751)。
Antibody therapeutics and vaccines for coronavirus disease 2019(COVID-19)have been approved in many countries,with most being developed based on the original strain of severe acute respiratory syndrome coronavirus 2(S...
关键词：antibody therapy broad neutralizing antibody human coronaviruses SARS-CoV-2 
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