TGF-

作品数：98被引量：413H指数：10
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相关领域：医药卫生更多>>
相关作者：刘伏友彭佑铭易斌肖力徐惠绵更多>>
相关机构：南方医科大学郑州大学山东大学苏州大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金浙江省自然科学基金更多>>
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Research p rogress on Chinese herbal drugs in the TGF- β signaling pathway involved in epithelial-mesenchymal transition
《Cancer Advances》2024年第17期1-12,共12页Hui-Juan Cao Chen-Xi Wu Xiao-Le Xian Yong-Sen Jia Yue-Yue Yu Shu Zhao Ting-Ting Fu 
supported by the Science and Technology Project of Hebei Education Department(QN2018060);Hebei Natural Science Foundation(H2022209027);Tangshan Science and Technology Project(21130230C)and Tangshan Talent Funding Project(A202203021);the Central Government Guides Local Funds For Science a nd Technology Development(Free Exploration o f Basic Research):the synergistic effect of nuclear targeted PTX/CUR nanodelivery system combined photothermal/photodynamic on breast cancer(236Z2704G);Natural Science Foundation of Hebei Province(H2022209068).
Epithelial-mesenchymal transition is a well-defined,reversible process in which epithelial cells lose their epithelial phenotype and acquire mesenchymal-like features.Epithelial-mesenchymal transition contributes sign...
关键词：epithelial-mesenchymal transition cancer Chinese medicine INVASION METASTASIS 
Role of integrin b1 and tenascin C mediate TGF-SMAD2/3 signaling in chondrogenic differentiation of BMSCs induced by type I collagen hydrogel
《Regenerative Biomaterials》2024年第5期59-73,共15页Yuanjun Huang Miao Sun Zhenhui Lu Qiuling Zhong Manli Tan Qingjun Wei Li Zheng 
supported by the Guangxi Scientific Research and Technological Development Foundation(grant number GuikeAB23026049);Guangxi Natural Science Foundation(grant number 2023GXNSFBA026034);the National Natural Science Foundation of China(grant number 82360426).
Cartilage defects may lead to severe degenerative joint diseases.Tissue engineering based on type I collagen hydrogel that has chondrogenic potential is ideal for cartilage repair.However,the underlying mechanisms of ...
关键词：collagen hydrogel chondrogenic induction integrin b1 tenascin C TGF-SMAD2/3 signaling 
舒筋健腰丸干预TGF- β1/Smad通路抑制大鼠黄韧带纤维化的研究被引量：2
《中国中医基础医学杂志》2023年第10期1650-1654,共5页冯蓬 李路广 李建国 高春雨 高景华 刘海英 
中国中医科学院望京医院院级科研课题(2021-HX-7)。
目的基于转化生长因子(transforming growth factor,TGF)β1/Smad通路探讨舒筋健腰丸对黄韧带纤维化模型大鼠的影响和作用机制。方法40只SD大鼠随机分为正常组,假手术组,模型组,舒筋健腰丸低、高剂量组,每组8只,采用腰椎失稳法建立黄韧...
关键词：舒筋健腰丸 TGF-β1/Smad通路 黄韧带 纤维化 胶原蛋白 
The role of TGF-beta3 in cartilage development and osteoarthritis被引量：9
《Bone Research》2023年第1期108-123,共16页Xinmei Du Linyi Cai Jing Xie Xuedong Zhou 
National Natural Science Foundation of China(81771047 to J.X.,81670978 and 81870754 to X.Z.);Sichuan Science&Technology Innovation Talent Project(2022JDRC0044)。
Articular cartilage serves as a low-friction,load-bearing tissue without the support with blood vessels,lymphatics and nerves,making its repair a big challenge.Transforming growth factor-beta 3(TGF-β3),a vital member...
关键词：CARTILAGE protective VERSATILE 
Anti-PD-L1/TGF-BR fusion protein (SHR-1701) overcomes disrupted lymphocyte recovery-induced resistance to PD-1/PD-L1 inhibitors in lung cancer被引量：10
《Cancer Communications》2022年第1期17-36,共20页Bo Cheng Kaikai Ding Pengxiang Chen Jianxiong Ji Tao Luo Xiaofan Guo Wei Qiu Chunhong Ma Xue Meng Jian Wang Jinming Yu Yuan Liu 
NationalKeyResearch and Develop-ment Projects of China,Grant/Award Number:2018YFC1312201;Academic Promotion Programof Shandong First Medical University,Grant/AwardNum-ber:2019ZL002;NationalNatural Sci-ence Foundation of China,Grant/Award Numbers:81803096,81972863,81627901,82030082;Natural Science Foundation of Shandong Province,Grant/AwardNum-ber:ZR201807080057;Cancer Institute and Hospital,ChineseAcademy of Medical Sci-ences,Grant/Award Number:2019RU071;supported by funding from the Shandong Provincial Natural Science Foundation(ZR201807080057),the National Key Research and Development Projects of China(2018YFC1312201),Cancer Institute and Hospital,Chinese Academy of Medical Sciences(2019RU071),the Academic Promotion Program of Shandong First Medical University(2019ZL002),and the National Natural Science Foundation of China(81803096,81972863,81627901,and 82030082).
Background:Second-generation programmed cell death-protein 1/pro-grammed death-ligand 1(PD-1/PD-L1)inhibitors,such as bintrafusp alfa(M7824),SHR-1701,and YM101,have been developed to simultaneously block PD-1/PD-L1 an...
关键词：SHR IMPAIRED markedly 
P144 Increases Adipose Tissue Volume by Inhibiting TGF-<i>β</i>1-Mediated Fibrous Capsule Formation in a Tissue Engineering Chamber
《Journal of Biosciences and Medicines》2021年第12期98-109,共12页Yaodong Yuan Jianhua Gao Zi Jing Yan Shi Feng Lu Zhangbo Chen 
Tissue engineering chambers (TECs) represent a new and attractive in vivo tissue engineering model that can successfully generate mature adipose tissue. However, the newly formed adipose tissue is not able to fill the...
关键词：Adipose Tissue Tissue Engineering Chamber Capsule Formation Transforming Growth Factor-β1 P144 
Homeoprotein SIX1 compromises antitumor immunity through TGF-β-mediated regulation of collagens
《Cellular & Molecular Immunology》2021年第12期2660-2672,共13页Wancheng Liu Meiling Gao Lili Li Yu Chen Huimin Fan Qiaomei Cai Yueyue Shi Chaohu Pan Junxiao Liu Lucy S.Cheng Heng Yang Genhong Cheng 
This project was financially supported by the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-1-I2M-047,2016-I2M-1-005 and 2019-I2M-1-003);National Science funds of China(82073181,81802870,82102371 and 2017YFA0506200);Nonprofit Central Research Institute Fund of the Chinese Academy of Medical Sciences(2020-PT310-006,2019XK310002 and 2018TX31001);HY is supported by science funds from Jiangsu Province(BK20211554,BK20170407);the Innovative and Entrepreneurial Team grant(2018-2021)from Jiangsu Province;LL is supported by the Chinese Postdoctoral Science Foundation(2019M650564);Innovative and Entrepreneurial Doctor grant(2020-2022)from Jiangsu Province.
The tumor microenvironment(TME),including infiltrated immune cells,is known to play an important role in tumor growth;however,the mechanisms underlying tumor immunogenicity have not been fully elucidated.Here,we disco...
关键词：Homeoprotein SIX1 anti-tumor immunity collagens. 
Genetic variation of TGF-BR2 as a protective genotype for the development of colorectal cancer in men被引量：1
《World Journal of Gastrointestinal Oncology》2021年第11期1766-1780,共15页Noyko Stanilov Antonia Grigorova Tsvetelina Velikova Spaska Angelova Stanilova 
Supported by the Research Grants from Trakia University,Medical Faculty,Stara Zagora,Bulgaria,No.1/2017 and 2/2019.
BACKGROUND The role of transforming growth factor beta(TGF-β)signaling,including both the cytokine and their receptors,in the etiology of colorectal cancer(CRC)has been of particular interest lately.AIM To investigat...
关键词：Colorectal carcinoma CYTOKINE TGF-BR2 gene TGF-ΒR2G^([-875])A Single nucleotide polymorphism 
超声作用下CTGF-siRNA对大鼠肝纤维化基因治疗的实验研究被引量：1
《中国超声医学杂志》2021年第1期93-96,共4页程祖胜 夏国园 钱彩艳 董梁 孙建刚 江珍珍 王爱芝 
浙江省自然科学基金项目(No.Y2110966);浙江省医药卫生研究计划A类项目(No.2015KYA225、2013KYB269、2014KYA217)。
目的探讨利用超声微泡造影剂介导携带结缔组织生长因子-小干扰RNA(CTGF-siRNA)真核表达质粒转染大鼠肝细胞的有效性。方法 (1)构建CTGF-siRNA真核表达质粒;(2)将40只实验大鼠随机分为7组:正常组,实验对照组,CTGF-siRNA质粒组,超声联合...
关键词：肝纤维化 超声 CTGF-siRNA 基因治疗 
KLF2 inhibits TGF-β-mediated cancer cell motility in hepatocellular carcinoma被引量：3
《Acta Biochimica et Biophysica Sinica》2020年第5期485-494,共10页Yining Li Shuo Tu Yi Zeng Cheng Zhang Tian Deng Weicheng Luo Lingyan Lian Ling Chen Xiangyang Xiong Xiaohua Yan 
This work was supported by the grants from the National Natural Science Foundation of China(Nos.31671460 and 31871378 to.X.Y),the Natural Science Foundation of Jiangxi Province of China(No.20171ACB21004 to XY and No.20192BAB205118 to S.T.),and the Special Funding Project for Graduate Student Innovation of Nanchang University(No.CX2019133 to YL.).
Feedback regulation plays a pivotal role in determining the intensity and duration of TGF-p signaling and subsequently affecting the pathophysiological roles of TGF-p,including those in liver malignancy.KLF2,a member ...
关键词：TGF-p signaling SMAD KLF2 feedback hepatocellular carcinoma cell motility 
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