To the Editor:Idiopathic inflammatory myopathies(IIMs)are a diverse group of rare and refractory systemic autoimmune diseases.DNA methylation,influenced by both inherited DNA sequences and environmental exposure,is a ...
supported by grants from the China International Medical Foundation(No.Z-2018-40);the Nantong Science and Technology Bureau Project(Nos.MSZ18108,JCZ20058,and JCZ2022026);the Special Clinical Basic Research Key Project of Nantong University(No.2019JZ001)
To the Editor:Dermatomyositis(DM)is a rare autoimmune disease characterized by specific cutaneous manifestations and proximal muscle weakness,in which abnormalities of nailfold capillary(NFC)and serum levels of vascul...
supported by grants from the Jiangsu Provincial Key R&D Program(Social Development)(No.BE2019663);the Suzhou Health and Key Talent Project(No.GSWS2019011).
Dermatomyositis(DM)is an idiopathic inflammatory myopathy,with typical cutaneous manifestations and muscle lesions,usually involving multiple organs.Patients with antimelanoma differentiation-associated gene-5(MDA5)DM...
This work was supported by grants from the National Natural Science Foundation of China(Nos.81801615 and 81871289).
Background:Clinically amyopathic dermatomyositis(CADM)is a unique sub-type of idiopathic inflammatory myopathies with a high prevalence of interstitial lung disease(ILD).Poor prognosis of the patients was strongly ass...
Idiopathic inflammatory myopathies (IIMs) are heterogeneous disorders characterized by chronic muscle weakness and muscle fatigue and mononuclear cell infiltration into skeletal muscle.[1] The most common subgroups in...
Background:The immunopathologic mechanism underlying dermatomyositis (DM) and polymyositis (PM) remains poorly understood.Many cytokines play a pathogenic role in DM and PM.lnterleukin 21 (IL-21) has a pleiotro...
To the Editor:A 54-year-old man developed painful ulcers on the neck one month ago,followed by periorbital edema.The ulcers then spread to his trunk,back,and upper arms.He had muscle weakness,mild muscle soreness wit...
Dermatomyositis (DM) and polymyositis (PM) are idiopathic inflammatory myopathies with unknown etiology. The incidence of both diseases is estimated at 4 to 10 cases per million people per year.1 Classical DM pati...
Background Interstitial lung disease (ILD) is a serious lung complication in polymyositis (PM) and dermatomyositis (DM) which affects prognosis and requires a more aggressive approach in therapy. This study inve...