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Unraveling the therapeutic potential of Calculus Bovis in liver cancer:A novel step for targeted cancer treatment
《World Journal of Gastroenterology》2025年第3期127-129,共3页Xing-Yu Chen Xiang Lan 
Hepatocellular carcinoma is one of the leading causes of cancer-related deaths globally,and effective treatments are urgently needed.The present study aimed to investigate the inhibitory effect of Calculus Bovis(CB)on...
关键词：Calculus Bovis Liver cancer M2 tumor-associated macrophage polarization Wnt/β-catenin Pathway Tumor microenvironment 
Exploring a new chapter in traditional Chinese medicine:The potential of Calculus bovis in liver cancer treatment
《World Journal of Clinical Oncology》2024年第12期1520-1527,共8页Huang Du Hong-Bin Chen Yu Zhao 
In the ongoing quest for new treatments in medicine,traditional Chinese medicine offers unique insights and potential.Recently,studies on the ability of Calculus bovis to inhibit M2-type tumour-associated macrophage p...
关键词：Calculus bovis M2 tumor-associated macrophage polarization Liver cancer Wnt/β-catenin pathway The tumor microenvironment 
Chemical Synthesis of Globo H and Mannobiose Glycopolymers and their Immunological Stimulation
《Chinese Journal of Polymer Science》2024年第11期1661-1667,I0007,共8页Zhi Zhang Ce-Ce Xue Ying-Le Feng Guo-Song Chen 
supported by the National Key Research and Development Program of China(No.2023YFA0915300);the National Natural Science Foundation of China(Nos.52125303 and 92356305);Innovation Program of Shanghai Municipal Education Commission(No.2023ZKZD02)。
Tumor-associated carbohydrate antigens(TACAs)provide a special class of tumor-specific antigens that show promising applications in cancer immunotherapy.However,the weak immunogenicity and structural complexity of TAC...
关键词：Globo-H Mannobiose GLYCOPOLYMER Convergent Synthesis Tumor-associated carbohydrate antigens 
An overview of the functions and mechanisms of APOBEC3A in tumorigenesis
《Acta Pharmaceutica Sinica B》2024年第11期4637-4648,共12页Yuqi Yang Nan Liu Likun Gong 
Shanghai Post-doctoral Excellence Program(No.2022689,China).
The APOBEC3(A3)family plays a pivotal role in the immune system by performing DNA/RNA single-strand deamination.Cancers mostly arise from the accumulation of chronic mutations in somatic cells,and recent research has ...
关键词：APOBEC3A DEAMINASE Mutation DNADAMAGE TUMORIGENESIS Tumor-associatedviruses MACROPHAGE Tumormicroenvironment 
Abnormally activated wingless/integrated signaling modulates tumor-associated macrophage polarization and potentially promotes hepatocarcinoma cell growth
《World Journal of Gastroenterology》2024年第41期4490-4495,共6页Wei-Lu Wang Paul Kwong Hang Tam Yan Chen 
Supported by Macao Science and Technology Development Fund,No.0086/2022/A and No.0097/2022/A2.
In this article,we comment on the article by Huang et al.The urgent development of new therapeutic strategies targeting macrophage polarization is critical in the fight against liver cancer.Tumor-associated macrophage...
关键词：Liver cancer Hepatocarcinoma cell Wingless/integrated signaling pathway M2 tumor-associated macrophages Polarization 
Concerting magnesium implant degradation facilitates local chemotherapy in tumor-associated bone defect
《Bioactive Materials》2024年第10期445-459,共15页Qingqing Guan Tu Hu Lei Zhang Mengjiao Yu Jialin Niu Zhiguang Ding Pei Yu Guangyin Yuan Zhiquan An Jia Pei 
supported by the National Key Research&Development Program of China(2021YFE0204900);the National Natural Science Foundation of China(52222108);Science and Technology Commission of Shanghai Municipality(22ZR1432000,23JC1402400).
Effective management of malignant tumor-induced bone defects remains challenging due to severe systemic side effects,substantial tumor recurrence,and long-lasting bone reconstruction post tumor resection.Magnesium and...
关键词：Tumor-associated bone defect Biodegradable magnesium-based implant Multifunctional composite coating Bone regeneration Local tumor therapy 
Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer被引量：16
《World Journal of Gastroenterology》2024年第29期3511-3533,共23页Zhen Huang Fan-Ying Meng Lin-Zhu Lu Qian-Qian Guo Chang-Jun Lv Nian-Hua Tan Zhe Deng Jun-Yi Chen Zi-Shu Zhang Bo Zou Hong-Ping Long Qing Zhou Sha Tian Si Mei Xue-Fei Tian 
Supported by National Natural Science Foundation of China,No.82074450;Education Department of Hunan Province,No.21A0243,No.21B0374,No.22B0397,and No.22B0392;Research Project of"Academician Liu Liang Workstation"of Hunan University of Traditional Chinese Medicine,No.21YS003;Hunan Administration of Traditional Chinese Medicine,No.B2023001 and No.B2023009;Hunan Provincial Natural Science Foundation of China,No.2023JJ40481。
BACKGROUND Calculus bovis(CB),used in traditional Chinese medicine,exhibits anti-tumor effects in various cancer models.It also constitutes an integral component of a compound formulation known as Pien Tze Huang,which...
关键词：Calculus bovis M2 tumor-associated macrophage polarization Liver cancer Wnt/β-catenin pathway Tumor microenvironment 
Converting“cold”to“hot”:epigenetics strategies to improve immune therapy effect by regulating tumor-associated immune suppressive cells被引量：4
《Cancer Communications》2024年第6期601-636,共36页Yijia Tang Guangzu Cui Haicong Liu Ying Han Changjing Cai Ziyang Feng Hong Shen Shan Zeng 
National Natural Science Foundation of China,Grant/Award Numbers:82373275,81974384,82173342,82203015;China Postdoctoral Science Foundation,Grant/Award Number:2023JJ40942;Nature Science Foundation of Hunan Province,Grant/Award Numbers:2021JJ3109,2021JJ31048,2023JJ40942;Nature Science Foundation of Changsha,Grant/Award Number:73201;CSCO Cancer Research Foundation,Grant/Award Numbers:Y-HR2019-0182,Y-2019Genecast-043;the Key Research and Development Program of Hainan Province,Grant/Award Numbers:ZDYF2020228,ZDYF2020125。
Significant developments in cancer treatment have been made since the advent of immune therapies.However,there are still some patientswithmalignant tumors who do not benefit from immunotherapy.Tumors without immunogen...
关键词：DNA methylation epigenetics strategy histone modification immune suppressive cell noncoding RNA 
Tracking interactions between TAMs and CAFs mediated by arginase-induced proline production during immune evasion of HCC
《Aggregate》2024年第3期439-449,共11页Chuanchen Wu Yuantao Mao Xinru Qi Xin Wang Ping Li Wen Zhang Bo Tang 
National Natural Science Foundation of China,Grant/Award Numbers:22134004,22074083,21927811;Key Research and Development Program of Shandong Province,Grant/Award Number:2018YFJH0502;Natural Science Foundation of Shandong Province of China,Grant/Award Numbers:ZR2020ZD17,ZR2023YQ016,ZR2021QB042;Local Science and Technology Development Fund Guided by the Central Government of Shandong Province,Grant/Award Number:YDZX2022012;The Major Science and Technology Innovation Project of Shandong Province,Grant/Award Number:2021ZDSYS09。
Synergistic changes between tumor-associated macrophages(TAMs)and cancer-associatedfibroblasts(CAFs)aggravated immune evasion of hepatocellular carci-noma(HCC),however,the underlying molecular mechanisms remain elusiv...
关键词：ARGINASE fluorescent probe immune evasion tumor-associatedfibroblasts tumor-associated macrophages 
Exploring the impact of non-small cell lung cancer tumor microbiome on the efficacy of chemotherapy and immune checkpoint inhibitors
《Cancer Advances》2024年第5期1-10,共10页Yan Dong Tian-Hao Qu Xi-Yue Zhang Hai-Yu Chen Yu-Jun Li Bin Zhang Ping Gao Ling Wang Chun-Xia Zhang Jia Li Xiao-Nan Cui 
Background:This study aimed to investigate the potential of intratumoral microbiota,gut microbiome,peripheral blood T-cell subsets,and inflammatory markers as predictive biomarkers for antitumor efficacy in patients w...
关键词：NSCLC tumor microenvironment gut microbiota tumor-associated microbiota 
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