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作品数：10被引量：50H指数：2
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相关领域：医药卫生生物学更多>>
相关期刊：《Acta Pharmacologica Sinica》《Asian Journal of Andrology》《Cell Research》《Cancer Drug Resistance》更多>>
相关基金：国家自然科学基金更多>>
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  • 学科=医药卫生—临床医学x
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LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer
《Cell Research》2025年第1期59-71,共13页Fei Li Pengfei Dai Huili Shi Yajuan Zhang Juan He Anuradha Gopalan Dan Li Yu Chen Yarui Du Guoliang Xu Weiwei Yang Chao Liang Dong Gao 
supported by the National Science Fund for Distinguished Young Scholars(32125013);the Excellent Young Scholars Fund(82422052);the National Natural Science Foundation of China(92253304,82002718,92357301,92253305,82461160322);the National Key R&D Program of China(2023YFC2506401);the Jiangsu Natural Science Foundation(BK20191077);the China National Postdoctoral Program for Innovative Talents(BX2021306,BX2024370);the Shanghai Oriental Talent Program,Shanghai Science and Technology Development Funds(22QA1409900,23ZR1470100);Shanghai Municipal Science and Technology Major Project,the Sanofi Scholarship and Heaye Program.
Epigenetic regulation profoundly influences the fate of cancer cells and their capacity to switch between lineages by modulating essential gene expression,thereby shaping tumor heterogeneity and therapy response.In ca...
关键词：LKB1 INACTIVATION PLASTICITY 
Role of prostate cancer stem-like cells in the development of antiandrogen resistance被引量：1
《Cancer Drug Resistance》2022年第2期459-471,共13页Prem Prakash Kushwaha Shiv Verma Shashank Kumar Sanjay Gupta 
Androgen deprivation therapy(ADT)is the standard of care treatment for advance stage prostate cancer.Treatment with ADT develops resistance in multiple ways leading to the development of castration-resistant prostate ...
关键词：Prostate cancer second-generation antiandrogens cancer stem cells castration resistance prostate cancer androgen deprivation therapy 
Novel flutamide regulated genes in the rat veritral prostate： differential modulation of their expression by castration and flutamide treatments
《Asian Journal of Andrology》2007年第6期801-808,共8页Anil M Limaye Irfan Asangani Namrata Bora Paturu Kondaiah 
Aim： To identify flutamide regulated genes in the rat ventral prostate. Methods： Total RNA from ventral prostates of control and flutamide treated rats were isolated. Differentially expressed transcripts were identi...
关键词：ANDROGENS ANTIANDROGEN CASTRATION differential display reverse transcriptase polymerase chain reaction FLUTAMIDE PROSTATE 
Long-term effectiveness of luteinizing hormone-releasing hormone agonist or antiandrogen monotherapy in elderly men with localizect prostate cancer （T1-2） ： a retrospective study被引量：1
《Asian Journal of Andrology》2007年第2期253-258,共6页Rupesh Raina Geetu Pahalajani Ashok Agarwal Craig Zippe 
Aim： To evaluate the long-term effectiveness, side effects and compliance rates of two types of drugs （luteinizing hormone-releasing hormone [LHRH] agonist and antiandrogen） that were used individually to treat pat...
关键词：localized prostate cancer ANTIANDROGEN prostate-specific antigen luteinizing hormone-releasing hormone agonist ANDROGEN ablation MONOTHERAPY 
The Antiandrogen Withdrawal Syndrome
《Journal of Nanjing Medical University》2002年第2期85-85,共1页华立新 吴宏飞 眭元庚 程双管 徐正铨 张炜 钱立新 
Objective\ To evaluate the response to antiandrogen withdrawal in patients with advanced prostate cancer treated with combined androgen blockade. Methods\ Twenty four cases of advanced prostate cancer (10 in stage C ...
关键词：Prostate cancer Prostate specific antigen Antiandrogen withdrawal 
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