CORONAVIRUSES

作品数：52被引量：111H指数：6
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相关领域：医药卫生农业科学更多>>
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Assessing the inhibition efficacy of clinical drugs against the main proteases of SARS-CoV-2 variants and other coronaviruses
《Quantitative Biology》2024年第3期324-328,共5页Wenlong Zhao Cecylia SLupala Shifeng Hou Shuxin Yang Ziqi Yan Shujie Liao Xuefei Li Nan Li 
National Key Research and Development Program of China,Grant/Award Number:2023YFA0913900;National Natural Science Foundation of China,Grant/Award Numbers:31971354,32100146,32170672,32271501。
The rapid evolution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)mainly due to its high mutation rate and rapid viral replication,has led to new variants resistant to the available vaccines and monocl...
关键词：drug resistance enzymatic activity main protease SARS-CoV-2 
Individual virome analysis reveals the general co-infection of mammal-associated viruses with SARS-related coronaviruses in bats
《Virologica Sinica》2024年第4期565-573,共9页Hao-Rui Si Ke Wu Jia Su Tian-Yi Dong Yan Zhu Bei Li Ying Chen Yang Li Zheng-Li Shi Peng Zhou 
supported by the National Key R&D Program of China(2021YFC2300901 to P.Z.);China Natural Science Foundation for outstanding scholars(82325032 to P.Z.);the Self-Supporting Program of Guangzhou Laboratory(SRPG22-001 to P.Z.;GZNL2023A01001 to ZLS).
Bats are the natural reservoir hosts for SARS-related coronavirus(SARSr-CoV)and other highly pathogenic microorganisms.Therefore,it is conceivable that an individual bat may harbor multiple microbes.However,there is l...
关键词：Bat Microbiome SARS-related coronavirus CO-INFECTION Alphacoronavirus 
Lycorine derivative effectively inhibits the replication of coronaviruses both in vitro and in vivo被引量：1
《hLife》2024年第2期75-87,共13页Liang Shen Jianzhong Zhao Ying Xia Junjie Lu Jiali Sun Jian Tang Hui Xing Lijuan Yin Yang Yang Chunhua Wang 
supported by National Natural Science Foundation of China (82002192,32302218);General project of Natural Science Foundation of Hubei Province (2019CFA016,2022CFB539,2022CFD107);Young and Middle-aged Talents Project of Hubei Provincial Education Department (Q20222605);Tianjin Municipal Science and Technology Committee (21JCQNJC01410);China Postdoctoral Science Foundation (2021M702460);Science and Technology Plan (in the field of medical and health care)of Xiangyang (2022YL05B,2022YL12A).
The established and ongoing prevalence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and seasonal human coronaviruses(HCoV)like HCoV-OC43,HCoV-NL63,and HCoV-229E,pose a continuous threat to public heal...
关键词：BROAD-SPECTRUM antiviral drug lycorine derivative Ly-8 
Is the time right for systematically serotyping SARS-related coronaviruses?
《hLife》2024年第1期4-5,共2页Chee Wah Tan Lin-Fa Wang 
IS THERE A NEED FOR SEROTYPING?The emergence and rapid selection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)immune escape variants have exerted significant challenges in many different ways,from pub...
关键词：IMMUNITY SARS establishing 
Coronaviruses RNA interacts with host miR-500a-5p and miR-501-5p to regulate multiple pathways
《Genes & Diseases》2023年第2期385-388,共4页Qi Guo Linghui Tan Jiajia Pan Songfang Wu Jiansong Huang Fang Yu Jinghan Wang 
The Coronavirus disease is the contagious disease. Clinical manifests vary from no symptoms, upper and lower respiratory tract infections, and even severe acute respiratory distress syndrome and multiple organs failur...
关键词：MIR ORGANS SPONGE 
Distinctive serotypes of SARS-related coronaviruses defined by convalescent sera from unvaccinated individuals被引量：4
《hLife》2023年第1期26-34,共9页Chee Wah Tan Feng Zhu Wan Ni Chia #Barnaby EYoung Aileen Ying Yan Yeoh Thomas Althaus Chee Fu Yung Wee Chee Yap Beng Lee Lim Mark I-C Chen Jinyan Zhang Yun Yan Mah Eric Voiglio Alex Sigal Jianxin Huo Shengli Xu Yee Joo Tan Kong-Peng Lam David Lye Lin-Fa Wang 
supported in part by grants from the National Medical Research Council(COVID19RF-001,COVID19RF-003,COVID19RF-0008,COVID19RF-0014,COVID19RF-0018,COVID19RF3-0060,MOH-000535/MOH-OFYIRG19nov-0002 and MOH-000505-02);SingHealth Duke-NUS Academic Medicine COVID-19 Rapid Response Research Grant(AM/COV001/2020);Collaborative Research Fund(C2103-20GF);Wellcome COVID-19 Grant on Understanding the Biological Significance SARS-CoV-2 Variants(226120/Z/22/Z);National Institute of Health NIAID(R01AI163118 and 5U01AI151797);National Public Health COVID Program of the Government of Monaco.
Multiple Omicron sub-lineages have emerged,with Omicron XBB and XBB.1.5 subvariants becoming the dominant variants globally at the time of this study.The key feature of new variants is their ability to escape humoral ...
关键词：SARS-CoV-2 SARS-CoV-1 SEROTYPE Omicron primary infection convalescent sera 
Mutation Prediction for Coronaviruses Using Genome Sequence and Recurrent Neural Networks
《Computers, Materials & Continua》2022年第10期1601-1619,共19页Pranav Pushkar Christo Ananth Preeti Nagrath Jehad F.Al-Amri Vividha Anand Nayyar 
Taif University Researchers are supporting project number(TURSP-2020/211),Taif University,Taif,Saudi Arabia.
The study of viruses and their genetics has been an opportunity as well as a challenge for the scientific community.The recent ongoing SARSCov2(Severe Acute Respiratory Syndrome)pandemic proved the unpreparedness for ...
关键词：COVID-19 genome sequence CORONAVIRIDAE RNN-LSTM RNN-GRU 
Co-existence and co-infection of influenza A viruses and coronaviruses: Public health challenges被引量：3
《The Innovation》2022年第5期38-47,共10页Jing Yang Yuhuan Gong Chunge Zhang Ju Sun Gary Wong Weifeng Shi Wenjun Liu George FGao Yuhai Bi 
supported by the National Key R&D Program of China(2021YFC2300903,2021YFE0109100,and 2021YFC2301300);Strategic Priority Research Program of Chinese Academy of Sciences(CAS)(XDB29010102);National Natural Science Foundation of China(NSFC)(32161123001,82161148010,and 32041010);Beijing Natural Science Foundation(M22029 and L192007);CAS Southeast Asia Biodiversity Research Institute(151C53KYSB20210023);Shenzhen Science and Technology Research and Development Project(JCYJ20180504165549581);the National Science and Technology Infrastructure of China(National Pathogen Resource Center-NPRC-32);supported by the Special Program of China Postdoctoral Science Foundation(2020T130123ZX);supported by National Natural Science Foundation of China(NSFC)Outstanding Young Scholars(31822055);Youth Innovation Promotion Association of CAS(Y2021034);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202208)。
Since the 20th century,humans have lived through five pandemics caused by influenza A viruses(IAVs)(H1N1/1918,H2N2/1957,H3N2/1968,and H1N1/2009)and the coronavirus(CoV)severe acute respiratory syndrome coronavirus 2(S...
关键词：INFECTION MAINTAIN GENERATING 
Secondary antiviral metabolites from fungi with special reference to coronaviruses
《BIOCELL》2022年第8期1979-1988,共10页MOHAMED SALEM MOHAMMAD EL-METWALLY WESAMELDIN SABER SALLY NEGM ATTALLA EL-KOTT YASSER MAZROUA ABEER MAKHLOUF MAHMOUD MOUSTAFA 
The authors are thankful to the Institute of Research and Consulting Studies at King Khalid University for supporting this research through Grant No.#6–93–S–2020.
Profound inspection of the life forms on the earth teaches how to be the complexity of interrelationships among the various systems.Because of the emergence of novel viruses all the time and the inadequate of vaccines...
关键词：COVID-19 SARS-CoV-2 ANTIBIOTICS VIRUS FUNGI 
An Age of Emerging and Reemerging Pandemic Threats
《Health》2022年第10期1021-1037,共17页Syed Amin Tabish Syed Nabil 
Today, we are confronted with an unprecedented crisis this world has never experienced before. Infectious diseases remain among the leading causes of death and disability worldwide. Epidemics of new and old infectious...
关键词：EID PANDEMIC CORONAVIRUSES MONKEYPOX New Langya Virus Henipavirises 
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