云南高校图书馆联盟文献共享服务平台- CHIMERAS

CHIMERAS: 作品数：36被引量：28H指数：3; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：何维刘晓黄毅陈爱蓉李雪峰更多>>; 相关机构：北京大学北京大学深圳医院中国科学院发育生物学研究所山东大学更多>>; 相关期刊：《Asian Journal of Andrology》《四川生理科学杂志》《Science China(Life Sciences)》《Acta Pharmacologica Sinica》更多>>; 相关基金：国家自然科学基金广东省自然科学基金中国博士后科学基金更多>>

TransTACs:Transforming antibodies into targeted protein degraders: 《Acta Pharmaceutica Sinica B》2025年第2期1186-1188,共3页Yu Guo Jinxin Che Xiaowu Dong; Over the past two decades,proteolysis-targeting chimeras(PROTACs)have gradually evolved from chemical biology tools into potential clinical candidates,marking a significant advancement in our ability to modulate prote...; 关键词：Targeted protein degradation Membrane and extracellular proteins Transferrin receptor-targeting chimeras Protein homeostasis regulation Tumor therapy

Autophagy receptor-inspired chimeras:a novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation: 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第12期1115-1119,共5页Liwen WANG Huimei LIU Lanfang LI; supported by the National Natural Science Foundation of China(No.81970431);the Hunan Provincial Natural Science Foundation of China(No.2023JJ50136)。; Neurodegenerative diseases(NDDs),mainly including Huntington’s disease(HD),amyotrophic lateral sclerosis(ALS),and Alzheimer’s disease(AD),are sporadic and rare genetic disorders of the central nervous system.A key f...; 关键词：HUNTINGTON DISEASES ALZHEIMER

Emerging Human Pluripotent Stem Cell-Based Human–Animal Brain Chimeras for Advancing Disease Modeling and Cell Therapy for Neurological Disorders: 《Neuroscience Bulletin》2024年第9期1315-1332,共18页Yanru Ji Jenna Lillie McLean Ranjie Xu; Human pluripotent stem cell(hPSC)models provide unprecedented opportunities to study human neurological disorders by recapitulating human-specific disease mechanisms.In particular,hPSC-based human–animal brain chimer...; 关键词：Human pluripotent stem cell Human–animal chimera Neurological disorder Disease modeling Cell therapy Human neurons and glia MICROGLIA Organoid

Development of PROTACS degrading KRAS and SOS1: 《Oncology Research》2024年第8期1257-1264,共8页GERHARD HAMILTON MARIE-THERESE EGGERSTORFER SANDRA STICKLER; The Kirsten rat sarcoma virus—son of sevenless 1(KRAS-SOS1)axis drives tumor growth preferentially in pancreatic,colon,and lung cancer.Now,KRAS G12C mutated tumors can be successfully treated with inhibitors that cov...; 关键词：Proteolysis-targeting chimeras(PROTACs) Kirsten rat sarcoma virus(KRAS) Son of sevenless 1(SOS1) Von Hippel-Lindau Cereblon

Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy被引量：1: 《Acta Pharmacologica Sinica》2024年第8期1740-1751,共12页Zhi-feng Zou Lei Yang Hui-jun Nie Jing Gao Shu-min Lei Yi Lai Fan Zhang Ernst Wagner Hai-jun Yu Xiao-hua Chen Zhi-ai Xu; Financial supports from the National Natural Science Foundation of China(22074043,U22A20328,22177120);Science and Technology Commission of Shanghai Municipality(20430711800 and 23ZR1475000);the Sino German Workshop grant(W-0005,LMU/Fudan U)were appreciated.; Proteolysis targeting chimeras(PROTACs)have emerged as revolutionary anticancer therapeutics that degrade disease-causing proteins.However,the anticancer performance of PROTACs is often impaired by their insufficient ...; 关键词：proteolysis-targeting chimeras tumor-targeted delivery precise protein degradation combination therapy triple-negative breast cancer

多肽靶向嵌合体通过促进tau蛋白特异性去磷酸化治疗阿尔茨海默病和其他tau蛋白病被引量：1: 《Science Bulletin》2024年第8期1137-1152,共16页苏静芬肖越魏林郁雷慧杨孙飞王围霞尹君熊瑞李师宏张配周颖王小川郑杰王建枝; supported by the National Natural Science Foundation of China(82230041,91949205,31730035,81721005);the National Key R&D Program of China(2016YFC1305800);the Guangdong Provincial Key S&T Program(018B030336001)。; Abnormal hyperphosphorylation and accumulation of tau protein play a pivotal role in neurodegeneration in Alzheimer’s disease(AD)and many other tauopathies.Selective elimination of hyperphosphorylated tau is promisin...; 关键词：TAU Dephosphorylation-targeting chimeras Therapeutic potential TAUOPATHY

Applications and prospects of cryo-EM in drug discovery被引量：2: 《Military Medical Research》2023年第6期848-861,共14页Kong-Fu Zhu Chuang Yuan Yong-Ming Du Kai-Lei Sun Xiao-Kang Zhang Horst Vogel Xu-Dong Jia Yuan-Zhu Gao Qin-Fen Zhang Da-Ping Wang Hua-Wei Zhang; funded by the National Natural Science Foundation of China (NSFC, 31900046, 81972085, 82172465 and 32161133022);the Guangdong Provincial Key Laboratory of Advanced Biomaterials (2022B1212010003);the National Science and Technology Innovation 2030 Major Program (2022ZD0211900);the Shenzhen Key Laboratory of Computer Aided Drug Discovery (ZDSYS20201230165400001);the Chinese Academy of Science President’s International Fellowship Initiative (PIFI)(2020FSB0003);the Guangdong Retired Expert (granted by Guangdong Province);the Shenzhen Pengcheng Scientist;NSFC-SNSF Funding (32161133022);Alpha Mol&SIAT Joint Laboratory;Shenzhen Government Top-talent Working Funding and Guangdong Province Academician Work Funding。; Drug discovery is a crucial part of human healthcare and has dramatically benefited human lifespan and life quality in recent centuries, however, it is usually time-and effort-consuming. Structural biology has been de...; 关键词：Cryo-electron microscopy(cryo-EM) Drug discovery Structure-based drug design Fragment-based drug discovery Proteolysis targeting chimeras Drug repurposing Artificial intelligence(AI)

A Proximity-Triggered Strategy toward Transferable Proteolysis Targeting Chimeras: 《CCS Chemistry》2023年第6期1433-1442,共10页Yuena Wang Rongtong Zhao Chuan Wan Wei Kang Rui Wang Chengyao Chiang Xiaochun Guo Qi Chang Zhanfeng Hou Yuxin Ye Qinhong Luo Ziyuan Zhou Jianbo Liu Shuiming Li Dongyuan Wang Feng Yin Zigang Li; Weare grateful for the financial support from the Natural Science Foundation of China(grant nos.21778009,21977010,and 22007033);National Key Research and Development Program“Synthetic Biology”Key Special Project of China(grant no.2018YFA0902504);China Postdoctoral Science Foundation(grant no.2021M690220);the Natural Science Foundation of Guangdong Province(grant nos.2020A1515010522,2020A1515010766,2019A1515110487,and 2019A151-5111184);the Foundation for Basic and Applied Research of Guangdong Province(grant no.2019A1515110489);and the Shenzhen Science and Technology Innovation Committee(grant nos.JCYJ20180507181527112,JCYJ-201805081522131455,and JCYJ20170817172023838).; Over the past 20 years,great efforts have been invested in developing site-specific approaches to protein modification to dissect protein functions directly and accurately.Here,we report a proximitytriggered group tra...; 关键词：SULFONIUM protein covalent modification proteolysis targeting chimeras site-specific modification degradation

Discovery of novel exceptionally potent and orally active c-MET PROTACs for the treatment of tumors with MET alterations: 《Acta Pharmaceutica Sinica B》2023年第6期2715-2735,共21页Pengyun Li Changkai Jia Zhiya Fan Xiaotong Hu Wenjuan Zhang Ke Liu Shiyang Sun Haoxin Guo Ning Yang Maoxiang Zhu Xiaomei Zhuang Junhai Xiao Zhibing Zheng Song Li; supported by Major New Drugs Innovation and Development (2018ZX09J18102-002, China)。; Various c-mesenchymal-to-epithelial transition(c-MET) inhibitors are effective in the treatment of non-small cell lung cancer;however, the inevitable drug resistance remains a challenge, limiting their clinical effica...; 关键词：Cancer therapy Drug design C-MET Proteolysis targeting chimeras(PROTACs) Drug resistance

Current strategies for improving limitations of proteolysis targeting chimeras: 《Chinese Chemical Letters》2023年第6期144-156,共13页Chunlan Pu Shirui Wang Lei Liu Zhonghui Feng Hongjia Zhang Qianyuan Gong Yueshan Sun Yuanbiao Guo Rui Li; supported by National Natural Science Foundation of China(No.81773195);Sichuan Science and Technology Program(No.2021YJ0220);Technology Innovation Research and Development Project of Chengdu(No.2022-YF05-01982-SN);the Foundation of Science and Technology Department of Sichuan Province(No.2022YFS0172)。; Proteolysis targeting chimeras(PROTACs)are bifunctional degrader molecules via hijacking the ubiquitinproteasome system(UPS)to specifically eliminate targeted proteins.PROTACs have gained momentum as a new modality of...; 关键词：PROTACs Targeted protein degradation Oral bioavailability Cell permeability Tumor targeting

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

CHIMERAS

检索结果分析

下载全文

高级检索检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

CHIMERAS

检索结果分析

下载全文

用户登录

高级检索检索式检索