KARYOPHERIN

作品数:8被引量:26H指数:3
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相关领域:医药卫生生物学更多>>
相关作者:秦晓辉王芳彭星华霍艳兵张玲娜更多>>
相关机构:苏州大学东南大学邯郸市第一医院浙江省台州医院更多>>
相关期刊:《Neuroimmunology and Neuroinflammation》《现代肿瘤医学》《中国普通外科杂志》《浙江医学》更多>>
相关基金:浙江省医药卫生科学研究基金国家自然科学基金国家高技术研究发展计划更多>>
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CircBACH1调节miR-101-3p/KPNA2轴对骨肉瘤细胞增殖、凋亡和侵袭的影响
《现代肿瘤医学》2024年第22期4254-4261,共8页张立喜 杨健 史博 
河北省医学科学研究课题计划项目(编号:20200332)。
目的:探究环状RNA BACH1(circBACH1)靶向微小RNA-101-3p(miR-101-3p)/核转运蛋白α2(KPNA2)轴对骨肉瘤(OS)细胞增殖、凋亡和侵袭的影响。方法:qRT-PCR法分析OS组织中circBACH1和miR-101-3p表达水平。双荧光素酶检测circBACH1和miR-101-3...
关键词:环状RNA BACH1 微小RNA-101-3p 核转运蛋白karyopherinα2 骨肉瘤 增殖 凋亡 侵袭 
A karyopherin constrains nuclear activity of the NLR protein SNC1 and is essential to prevent autoimmunity in Arabidopsis被引量:2
《Molecular Plant》2021年第10期1733-1744,共12页Min Jia Xueqi Shen Yu Tang Xuetao Shi Yangnan Gu 
X.Shen and X.Shi were supported by Tsinghua-Peking Joint Center tor Life Sciences;This project was supported by the USDA National Institute of Food and Agriculture(HATCH project CA-B-PLB-0243-H);the National Science Foundation(grant MCB-2049931);startup funds from Inno-vative Genomics Institute and University of California Berkeley.
The nucleotide-binding and leucine-rich repeat(NLR)proteins comprise a major class of intracellular immune receptors that are capable of detecting pathogen-derived molecules and activating immunity and cell death in p...
关键词:KARYOPHERIN KA120 SNC1 nucleocytoplasmic transport immune activation 
KPNA2在三阴性乳腺癌中的表达特点及其与患者远期预后的关系被引量:4
《中国普通外科杂志》2021年第6期748-752,共5页彭星华 王芳 史帅 秦晓辉 霍艳兵 
背景与目的:探讨核转运蛋白karyopherin α2(KPNA2)在三阴性乳腺癌患者中的表达特点与患者远期预后的关系。方法:选取2017年1月—2020年2月我院保存的三阴性乳腺癌标本60例以及非三阴性乳腺癌标本59例,同时选取正常乳腺组织50例作为对...
关键词:乳腺肿瘤/病理学 核转运蛋白karyopherinα2 三阴性乳腺癌 预后 
胞核中核转运受体蛋白Karyo-pherin alpha 2水平与胃癌预后的关系研究被引量:2
《浙江医学》2021年第10期1042-1045,I0003,共5页张玲娜 甘梅富 周梦雅 翁寿向 李玉晶 蒋菲 
浙江省医药卫生科技计划(2016KYA190)。
目的探讨核转运受体蛋白Karyopherin alpha 2(KPNA2)水平与胃癌患者各临床病理参数及预后的关系。方法选取2010年1月至2014年11月浙江省台州医院行手术切除的胃癌患者肿瘤石蜡包埋标本103例,制成组织芯片,使用免疫组化法检测胃癌及癌旁...
关键词:胃癌 核转运受体蛋白 Karyopherin alpha 2 p53 预后 
Putting things in place for fertilization: discovering roles for importin proteins in cell fate and spermatogenesis被引量:3
《Asian Journal of Andrology》2015年第4期537-544,共8页Kate L Loveland Andrew T Major Romaly Butler Julia C Young David A Jan Yoichi Miyamoto 
Importin proteins were originally characterized for their central role in protein transport through the nuclear pores, the only intracellular entry to the nucleus. This vital function must be tightly regulated to cont...
关键词:cell fate cell stress IMPORTIN KARYOPHERIN nucleocytoplasmic transport SPERMATID SPERMATOCYTE SPERMATOGENESIS 
A potential role of karyopherin a2 in the impaired maturation of dendritic cells observed in glioblastoma patients
《Neuroimmunology and Neuroinflammation》2015年第1期8-14,共7页Konstantinos Gousias Alexander von Ruecker Gerrit H.Gielen Pitt Niehusmann Andreas Waha Hartmut Vatter Matthias Simon 
Aim:Patients with glioblastomas demonstrate well‑documented immunological impairments including decreased numbers of mature dendritic cells(DCs).Recent data identified karyopherin a2(KPNA2),a nucleocytoplasmic shuttli...
关键词:GLIOBLASTOMAS isocitrate dehydrogenase‑1 karyopherin a2 mature dendritic cells O6‑methylguanine DNA methyltransferase p53 
Nucleocytoplasmic shuttling of Smad proteins被引量:16
《Cell Research》2009年第1期36-46,共11页Caroline S Hill 
Nuclear accumulation of active Smad complexes is crucial for transduction of transforming growth factor β (TGF-β)- superfamily signals from transmembrane receptors into the nucleus. It is now clear that the nucleo...
关键词:SMAD nuclear import and export TGF-β-superfamily signaling KARYOPHERIN nucleocytoplasmic shuttling 
Identification of karyopherin-alpha 2 as an Oct4 associated protein
《Journal of Genetics and Genomics》2008年第12期723-728,共6页Xiangqun Li Lei Sun Ying Jin 
supported by the Shanghai Science & Technology Developmental Foundations (No.06dj14001);the National High Technology Research and Development Program of China (No. 2006AA02Z197, 2006CB943901, and 2007CB947904)
The POU domain transcription factor Oct4 is a master regulator in maintaining self-renewal and pluripotency of embryonic stem (ES) cells. To further explore the functional network of Oct4, the yeast two-hybrid syste...
关键词:OCT4 karyopherin-alpha 2 yeast two-hybrid nuclear localization signal 
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