X.Shen and X.Shi were supported by Tsinghua-Peking Joint Center tor Life Sciences;This project was supported by the USDA National Institute of Food and Agriculture(HATCH project CA-B-PLB-0243-H);the National Science Foundation(grant MCB-2049931);startup funds from Inno-vative Genomics Institute and University of California Berkeley.
The nucleotide-binding and leucine-rich repeat(NLR)proteins comprise a major class of intracellular immune receptors that are capable of detecting pathogen-derived molecules and activating immunity and cell death in p...
Importin proteins were originally characterized for their central role in protein transport through the nuclear pores, the only intracellular entry to the nucleus. This vital function must be tightly regulated to cont...
Aim:Patients with glioblastomas demonstrate well‑documented immunological impairments including decreased numbers of mature dendritic cells(DCs).Recent data identified karyopherin a2(KPNA2),a nucleocytoplasmic shuttli...
Nuclear accumulation of active Smad complexes is crucial for transduction of transforming growth factor β (TGF-β)- superfamily signals from transmembrane receptors into the nucleus. It is now clear that the nucleo...
supported by the Shanghai Science & Technology Developmental Foundations (No.06dj14001);the National High Technology Research and Development Program of China (No. 2006AA02Z197, 2006CB943901, and 2007CB947904)
The POU domain transcription factor Oct4 is a master regulator in maintaining self-renewal and pluripotency of embryonic stem (ES) cells. To further explore the functional network of Oct4, the yeast two-hybrid syste...