Inflammatory events in the corneal stroma may activate keratocytes and trigger their transition towards myofibroblasts,which now produce different extracellular matrix(ECM)proteins thus causing corneal opacification.C...
Supported by Natural Science Foundation of Shaanxi Province(No.2017JM8040);Xi’an Science and Technology Project [No.2017116SF/YX010(7)]
AIM: To investigate the expression of visual system homeobox 1(VSX1) and myofibroblast marker alpha smooth muscle actin(α-SMA) in keratoconus(KC). METHODS: Thirty corneal tissue were collected from KC patients after ...
Singapore National Eye Centre HREF 0618-2;Singapore National Research Foundation under Clinician Scientist Award-Senior Investigator Category(JRNMRR163801);National Medical Research Council,Ministry of Health,Singapore.
Background:Human corneal stromal keratocytes propagated in culture media supplemented with human amnion extract(AME)can correct early corneal haze in an animal model.Clinical application of cultivated keratocytes is l...
Supported by the National Natural Science Foundation of China(No.81271716)
AIM:To investigate the feasibility of corneal anterior lamellar reconstruction with human corneal epithelial cells and fibroblasts,and an acellular porcine cornea matrix(APCM) in vitro.·METHODS:The scaffold was p...
supports of the China Scholarship Council(CSC)for the author's study(J Wang and X Song);the Alexander von Humboldt Foundation for supporting the work of Dr.N.Szentmary at the Department of Ophthalmology of Saarland University,Homburg/Saar,Germany;supported by"Zentrales Innovationsprogram Mittelstand(ZIM)"of the German Federal Ministry of Economics and Technology(Project number:KF2152004MD0)
Riboflavin-UVA photodynamic inactivation is a potential treatment altemative in therapy resistant infectious keratitis. The purpose of our study was to determine the impact of riboflavin-UVA photodynamic inactivation ...
Background Transforming growth factor β (TGFβ) is one of the most important growth factors in the development of fibrosis and scarring on cornea. Smad7, an inhibitory Smad, can inhibit TGFβ signal transduction. I...
The efficiency and safe range of LipofectamineTM2000 (LF2000)/bcl-xl applied in human keratocytes, the optimal ratio of LF2000/bcl-xl and the bcl-xl gene expression in human keratocytes were investiaged. By using tryp...