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Genetic and environmental factors contributing to anophthalmia and microphthalmia:Current understanding and future directions
《World Journal of Clinical Pediatrics》2025年第2期9-29,共21页Shiwali Goyal Shailja Tibrewal Ria Ratna Vanita Vanita 
Anophthalmia is defined as a complete absence of one eye or both the eyes,while microphthalmia represents the presence of a small eye within the orbit.The estimated birth prevalence for anophthalmia is approximately 3...
关键词：ANOPHTHALMIA MICROPHTHALMIA Eye development SRY-Box 2 Orthodenticle homeobox 2 
G蛋白偶联受体和homeobox基因在卤虫早期发育脑神经节中的潜在调控作用
《水生生物学报》2025年第4期99-110,共12页闫智超 段虎 汪俊芳 隋丽英 
天津市海洋资源与化学重点实验室开放课题(202303)资助。
为揭示卤虫变态发育过程中的神经调控机制,研究报告了孤雌生殖卤虫三个典型发育阶段脑神经节的转录动态,鉴定了各阶段特异表达的基因并预测了其功能。结果表明:第1龄期的高表达基因(HEG)涉及大量的有机物代谢和免疫调节,如含硫化合物转...
关键词：个体发育 脑神经节 G蛋白偶联受体 HOMEOBOX 卤虫 
Mechanistic link between long noncoding RNA and stability of oncogene reveals stemness and chemoresistance of hepatocellular carcinoma
《World Journal of Gastroenterology》2025年第7期160-162,共3页Yu-Bo Liang Xing-Ming Chen Wan-Ling Luo Yang Ke 
Supported by the National Natural Science Foundation of China,No.82103173 and No.82460461;Medical Subject Leader of Yunnan Province(General Surgery),No.D-2024029;Yunnan Fundamental Research Project for Excellent Young Scholars,No.202401AW070003;the Young and Mid-aged Academic and Technical Leader Reserve Talent Program of Yunnan Province,No.202205AC160063。
This letter comments on the recently published manuscript by Yu et al,in which the authors revealed a novel mechanism by which the m6A-modified long noncoding RNA kinesin family member 9-antisense RNA 1 promotes stemn...
关键词：Kinesin family member 9-antisense RNA 1 Hepatocellular carcinoma Ubiquitin-specific peptidase 1 Short stature homeobox 2 CHEMORESISTANCE 
Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis
《World Journal of Clinical Oncology》2025年第1期10-24,共15页Yang-Zheng Lan Zheng Wu Wen-Jia Chen Xin-Ning Yu Hua-Tao Wu Jing Liu 
Supported by the National Natural Science Foundation of China,No.82273457;the Natural Science Foundation of Guangdong Province,No.2023A1515012762 and No.2021A1515010846;Special Grant for Key Area Programs of Guangdong Department of Education,No.2021ZDZX2040;Science and Technology Special Project of Guangdong Province,No.210715216902829.
The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis acro...
关键词：Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis THERAPEUTICS 
Phosphorylation determines the glucose metabolism reprogramming and tumor-promoting activity of sine oculis homeobox 1
《Signal Transduction and Targeted Therapy》2025年第1期240-255,共16页Yanni Lin Ling Li Bin Yuan Fei Luo Xiujuan Zhang Yuanjun Yang Shaliu Luo Jing Lin Tianxing Ye Youzhi Zhang Shan Gao Qinong Ye 
supported by the National Natural Science Foundation of China(81930078 and 82330083 to Q.Y.and 81902838 to L.L.);the National Key Research and Development Program of China(2022YFA1104003 to Q.Y.);Natural Science Foundation of Beijing(7204284 to L.L.);Basic and Clinical Collaborative Research Enhanced Program of Anhui Medical University(2021xkjT025 to B.Y.);the Doctoral Start-up Foundation of Anhui Medical University(0110050201 to B.Y.).
Aerobic glycolysis is a hallmark of cancer and is regulated by growth factors,protein kinases and transcription factors.However,it remains poorly understood how these components interact to regulate aerobic glycolysis...
关键词：metabolism programming SINE 
N6-methyladenosine-modified long non-coding RNA KIF9-AS1 promotes stemness and sorafenib resistance in hepatocellular carcinoma by upregulating SHOX2 expression
《World Journal of Gastroenterology》2024年第48期5174-5190,共17页Yong Yu Xiang-Hong Lu Jin-Song Mu Jiang-Yun Meng Jiang-Shan Sun Hai-Xu Chen Yang Yan Ke Meng 
Supported by the National Natural Science Foundation of China,No.82271628.
BACKGROUND Hepatocellular carcinoma(HCC)is a prevalent and aggressive tumor.Sorafenib is the first-line treatment for patients with advanced HCC,but resistance to sorafenib has become a significant challenge in this t...
关键词：Hepatocellular carcinoma STEMNESS Sorafenib resistance Long non-coding RNA KIF9-AS1 Short stature homeobox 2 
Bushen Huoxue decoction(补肾活血汤)improves the reproduction of endometriosis-associated infertility by regulating Homeobox A10 and αlpha(v)beta(3)integrin expression
《Journal of Traditional Chinese Medicine》2024年第6期1137-1145,共9页TANG Weiwei LIU Kaili FAN Xumei ZHU Li ZENG Zheng SUN Jiali SHI Jie ZHANG Zhenzhen GUI Tao WAN Guiping 
National Natural Science Foundation-funded Project:the Mechanism of Effect of Bushen Huoxue Decotion on Endometrial Receptivity in Endometriosis (No. 81603372);National Natural Science Foundation-funded Project:to Investigate the Mechanism of Bushen Huoxue Decoction in Improving Endometrial Receptivity Based on SUMOylation of Homeobox A10 (No. 82274190);Jiangsu Commission of Health Project:to Investigate the Mechanism of Bushen Huoxue Decoction in Improving Endometrial Receptivity Based on Leukemia Inhibitory Factor Signaling (No. M2022079)。
OBJECTIVE: To investigate the mechanism of Bushen Huoxue decoction( 补肾活血汤, BSHXD) to treat endometriosis-induced infertility. MEDHODS: The main compounds of BSHXD were determined by high performance liquid chroma...
关键词：INFERTILITY ENDOMETRIOSIS homeobox A10 proteins integrin alpha Vbeta3 Bushen Huoxue decoction 
Retraction:long noncoding RNA CAT104 promotes cell viability,migration,and invasion in gastric carcinoma cells through activation of microRNA-381-inhibiting zinc finger e-box-binding homeobox 1(ZEB1)expression
《Oncology Research》2024年第11期1821-1821,共1页Oncology Research Editorial Office 
Following the publication,concerns have been raised about a number of figures in this article.The western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in man...
关键词：INVASION raised concerned 
Cone-rod homeobox transcriptionally activates TCF7 to promote the proliferation of retinal pigment epithelial and retinoblastoma cells in vitro
《International Journal of Ophthalmology(English edition)》2024年第11期1995-2006,共12页Na Zhao Ying-Ying Li Jia-Man Xu Mu-Yao Yang Yun-Zhe Li Thomas Chuen Lam Lei Zhou Qi-Hu Tong Jun-Tao Zhang Sheng-Zhan Wang Xin-Xin Hu Yu-Fei Wu Qin-Kang Lu Ting-Yuan Lang 
Supported by grants from the Zhejiang Medicine and Health Science and Technology Project(No.2018KY748);Ningbo Natural Science Foundation(No.2019A610352);Ningbo Major Scientific and Technological Research and“Unveiling and Commanding”Project(No.2021Z054);Chongqing Science&Technology Commission(No.CSTB2022NSCQ-MSX1413);Ningbo Clinical Research Center for Ophthalmology(No.2022L003);Ningbo Key Laboratory for Neuroretinopathy Medical Research,and the Project of NINGBO Leading Medical&Health Discipline(No.2016-S05).
AIM:To investigate the proliferation regulatory effect of cone-rod homeobox(CRX)in retinal pigment epithelium(RPE)and retinoblastoma(RB)cells to explore the potential application and side effect(oncogenic potential)of...
关键词：retinal pigment epithelial cell RETINOBLASTOMA cone-rod homeobox transcription factor 7 regenerative medicine tumorigenic potential 
Recent advancements in understanding of biological role of homeobox C9 in human cancers
《World Journal of Clinical Oncology》2024年第9期1168-1176,共9页Yong Zhang Jing Li 
Homeobox(HOX)C9,a member of the HOX family,is an important transcription factor,and it plays a significant role in various biological processes.This family of genes is highly valued for their essential roles in establ...
关键词：Homeobox C9 PROLIFERATION INVASION Malignant tumor Molecular mechanism 
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