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NLRP3 inhibitor dopamine receptors agonist as a potential therapeutic strategy for treatment of overactive immune responses in COVID-19: 《Reproductive and Developmental Medicine》2023年第2期65-67,共3页Jia-Lei Zhu Jing Jin Jing Tang; National Natural Science Foundation of China(82104148);Shanghai Sailing Program(21YF1403600);Shanghai"Rising Stars of Medical Talent"Youth Development Program(076478684Q/2022-00033);project of China Pharmaceutical Association(CMEI2022KPYJ00545); Patients infected with coronavirus disease 2019(COVID-19)have high serum levels of proinflammatory cytokines.The"cytokine storm"has become one of the major causes of death for critically ill patients infected by COVID...; 关键词：NLRP3 inflammasome Cytokine storm COVID-19 Dopamine receptors Medication regimen INTERLEUKIN

Cytokine nanosponges suppressing overactive macrophages and dampening systematic cytokine storm for the treatment of hemophagocytic lymphohistiocytosis被引量：3: 《Bioactive Materials》2023年第3期531-546,共16页Honglan Wang Huiwen Liu Jia Li Chunying Liu Hui Chen Junying Li Chunyan Sun Tao Guo Zhiqing Pang Bo Zhang Yu Hu; National Natural Science Foundation of China(82070228,81773283);National Key R&D Program of China(No.2019YFC1316204)。; Hemophagocytic lymphohistiocytosis(HLH)is a highly fatal condition with the positive feedback loop between continued immune cell activation and cytokine storm as the core mechanism to mediate multiple organ dysfunctio...; 关键词：Hemophagocytic lymphohistiocytosis Cytokine storm Nanosponge Macrophage activation Macrophage membranes coated nanoparticles LIPOPOLYSACCHARIDE JAK/STAT pathway

Aging induces severe SIV infection accompanied by an increase in follicular CD8+T cells with overactive STAT3 signaling被引量：1: 《Cellular & Molecular Immunology》2022年第9期1042-1053,共12页Hong-Yi Zheng Xue-Hui Wang Xiao-Yan He Min Chen Ming-Xu Zhang Xiao-Dong Lian Jia-Hao Song Yan Hu Wei Pang Yun Wang Zheng-Fei Hu Long-Bao Lv Yong-Tang Zheng; The work was supported by the National Key R&D Program of China(2021YFC2301703);National Natural Science Foundation of China(81771770,81671627,U1802284,81971548,82071847);National Resource Center for Non-Human Primates.; The number of elderly people living with HIV is increasing globally,and the condition of this population is relatively complicated due to the dual effects of aging and HIV infection.However,the impact of HIV infection...; 关键词：SIV AGING Follicle CD8 T cells

Types of Urinary Incontinence Prevalent among Kuwaiti Women with Type Two Diabetes Mellitus: 《Open Journal of Nursing》2017年第10期1131-1143,共13页Sanaa M. Taghaddom Florence E. Omu Fawzeyah S. H. S. AlHarbi Chitra Vellolikalam Samiha I. A. Dwaib Selma Joseph Gifta Jeevakumari; The aim of this study was to determine the types of urinary incontinence prevalent among Kuwaiti women with Type two Diabetes Mellitus attending the outpatient clinic at the Urology center and suggest appropriate nurs...; 关键词：Urinary BLADDER Dysfunction Stress INCONTINENCE URGE INCONTINENCE OVERACTIVE BLADDER Mixed INCONTINENCE TYPE TWO Diabetes Mellitus

The Aging Bladder in Females Evaluated by Urodynamics: 《Open Journal of Urology》2017年第3期54-64,共11页M. C. de Albuquerque Neto Leslie Clifford Noronha Araujo Thome Decio Pinheiro Barros Junior Joao Luiz Amaro Flavia Cristina Morone Pinto Fabio de Oliveira Vilar Salvador Vilar Correia Lima; Aim: To determine whether bladder functions deteriorate with age. Methods: Data contained in electronic medical record (INFOMED?) were used in this institutional retrospective review. Analysis was done on the urodynam...; 关键词：AGING URINARY BLADDER Diseases URINARY BLADDER NEUROGENIC OVERACTIVE URODYNAMICS

Efficacy and safety of onabotulinum toxin A for overactive bladder: 《World Journal of Clinical Urology》2016年第2期75-79,共5页Chintan K Patel Arthur P Mourtzinos; Overactive bladder(OAB) syndrome is a condition which affects 16.9% of women and 16.2% of men with a significant negative impact on quality of life. It is a condition characterized by urgency, with or without urge inc...; 关键词：Onabotulinum toxin A BOTOX OVERACTIVE BLADDER OVERACTIVE BLADDER NEUROGENIC BLADDER Urinary BLADDER DETRUSOR OVERACTIVITY

Does an “Overactive to Underactive Bladder Transition” Phenomenon Exist in a Rat Lumbar Spinal Canal Stenosis Model?被引量：1: 《Open Journal of Urology》2015年第5期57-64,共8页Noritoshi Sekido Jun Kida Daisuke Wakamatsu Hiroki Okada Hidekazu Matsuya; Purpose: To investigate the association between the maximum cystometric capacity (MCC) and other cystometric parameters in lumbar canal stenosis (LCS) rats. Material and Methods: One small hole was drilled at the fift...; 关键词：Underactive BLADDER DETRUSOR Underactivity Lumbar CANAL STENOSIS Animal MODEL OVERACTIVE BLADDER

MST4 Revealed a Molecular Brake to Prevent Overactive Inflammatory Responses: 《Bulletin of the Chinese Academy of Sciences》2015年第1期45-45,共1页ZHOU Zhaoca; funded by the National Natural Science Foundation of China;the Ministry of Science and Technology of China;the CAS and the Science&Technology Commission of Shanghai Municipality; Innate immunity is the frontline of defense against pathogens.Upon detection of pathogen-associated molecular patterns,Toll-like receptors(TLRs)will initiate innate immune responses,like inflammation,via activating th...; 关键词：炎症反应分子过度 TOLL样受体刹车先天性免疫病原体免疫反应

Expression of Large Conductance, Voltage- and Ca<sup>2+</sup>-Activated K<sup>+</sup>(BK) Channels in Human Urinary Bladder: Alteration of Subunit Expression Profile in Association with Bladder Outlet Obstruction: 《Open Journal of Urology》2013年第2期47-52,共6页Hidenori Zakoji Hideki Kobayashi Mitsuharu Yoshiyama Masayuki Takeda Isao Araki; Purpose: Large conductance, voltage- and Ca2+-activated K+ (BK) channel is thought to have a central role to regulate urinary bladder smooth muscle functions, and its dysfunction may lead to increase of urination freq...; 关键词：BK Channel OVERACTIVE BLADDER BLADDER Outlet OBSTRUCTION

Botulinum Toxin-A for the Treatment of Voiding Dysfunction: Our Initial Experience: 《Open Journal of Urology》2012年第2期67-71,共5页Sinharib Citgez Bulent Onal Fetullah Gevher Cagatay Dogan Omer Kurt Oktay Demirkesen Bulent Cetinel; Objective: Evaluation of Botulinum Toxin-A (BTX-A) as an alternative treatment option in patients whom previous treatments were failed. Methods: Between March 2005 and September 2006, a total 19 patients;16 patients w...; 关键词：BOTULINUM Toksin-A OVERACTIVE BLADDER VOIDING DYSFUNCTION

OVERACTIVE