Nucleosomal histone tails are subject to a vast repertoire of covalent modifications that alter the physical accessibility of their associated DNA,impacting gene expression.Specifically,the acetylation of histones is ...
the National Natural Science Foundation of China(32025003);the National Key Research and Development Program of China(2016YFA0500801)from the Chinese Ministry of Science and Technology.
The SAGA(Spt-Ada-Gcn5 acetyltransferase)complex is an evolutionarily conserved histone acetyltransferase complex that has a critical role in histone acetylation,gene expression,and various developmental processes in e...
supported by the National Natural Science Foundation of China to C.L.(32000380 and 31870289);Guangdong Basic and Applied Basic Research Foundation to C.L.(2021A1515011286);the Fundamental Research Funds for the Central Universities,Sun Yat-sen University to C.L(18lgzd12).
Switch defective/sucrose non-fermentable(SWI/SNF)chromatin remodeling complexes are multi-subunit machines that play vital roles in the regulation of chromatin structure and gene expression.However,the mechanisms by w...
The NF-Y transcription factor is a heterotrimer formed by evolu- tionarily conserved subunits: NF-YA, NF-YB, and NF-YC. NF-YB and NF-YC harbor a histone fold domain (HFD), structur- ally similar to that of nucleoso...
Incorporation of the histone variant H2A.Z into nucleosomes by the SWR1 chromatin remodeling complex is a critical step in eukaryotic gene regulation. In Arabidopsis, SWRlc and H2A.Z have been shown to con- trol gene ...
Brassinosteroid (BR) binding activates the receptor kinase BRI1 by inducing heterodimerization with its co- receptor kinase BAK1; however, the mechanisms that reversibly inactivate BRI1 remain unclear. Here we show ...
Intracellular protein routing is mediated by vesicular transport which is tightly regulated in eukaryotes. The protein and lipid homeostasis depends on coordinated delivery of de novo synthesized or recycled cargoes t...
The eukaryotic transcription factor NF-Y consists of three subunits (A, B, and C), which are encoded in Ara- bidopsis thaliana in multigene families consisting of 10, 13, and 13 genes, respectively. In principle, al...
The ARP2/3 complex, a highly conserved nucleator of F-actin polymerization, and its activator, the SCAR complex, have been shown to play important roles in leaf epidermal cell morphogenesis in Arabidopsis. However, th...