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MURINE: 作品数：533被引量：1411H指数：15; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：瞿佳王国俊向晓星李玉莉蔡雄更多>>; 相关机构：北京大学温州医学院附属眼视光医院第四军医大学西京医院南京医科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划国家教育部博士点基金更多>>

A Novel CA4P Polymeric Nanoparticle for Murine Hepatoma Therapy: 《Chinese Journal of Polymer Science》2023年第8期1223-1229,I0007,共8页Zhi-Lin Liu Xi-Tong Ren Yue Huang Jia-Li Sun Xiao-Shuang Wang Meng-Fei Zheng Lin-Jie Cui Xue-Fei Zhang Zhao-Hui Tang; financially supported by the Ministry of Science and Technology of China(No.2022YFE0110200);the Natural Science Foundation of Hunan Province of China(No.2021JJ30680);the National Natural Science Foundation of China(Nos.52203198,52025035 and 52103195)。; Combretastatin A4 phosphate(CA4P)is a potent vascular disrupting agent with good water solubility.However,it is only effective at high doses,which decreases clinical applicability.Herein,we designed stable CA4P polyme...; 关键词：CA4P polymeric nanoparticle Cholesterol derivatives Vascular disrupting agent Phosphate-guanidine coordination Drug controlled release

Inflammation-induced inhibition of chaperone-mediated autophagy maintains the immunosuppressive function of murine mesenchymal stromal cells被引量：4: 《Cellular & Molecular Immunology》2021年第6期1476-1488,共13页Jie Zhang Jiefang Huang Yuting Gu Mingxing Xue Fengtao Qian Bei Wang Wanlin Yang Hongshuang Yu Qiwei Wang Xin Guo Xinyuan Ding Jina Wang Min Jin Yanyun Zhang; supported by the Ministry of Science and Technology of China(2015CB943300 and 2011CB966200);the National Natural Science Foundation of China(81873447 and 81670540);The Program of Science and Technology Commission of Shanghai Municipality(19ZR1409200 and 19ZR1430900);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA01040000).; Macroautophagy has been implicated in modulating the therapeutic function of mesenchymal stromal cells(MSCs).However,the biological function of chaperone-mediated autophagy(CMA)in MSCs remains elusive.Here,we found th...; 关键词：chaperone-mediated autophagy mesenchymal stromal cells immunosuppressive capacity inflammatory microenvironment

Single-cell patterning and axis characterization in the murine and human definitive endoderm被引量：1: 《Cell Research》2021年第3期326-344,共19页Lin-Chen Li Xin Wang Zi-Ran Xu Yan-Chun Wang Ye Feng Liu Yang Wei-Lin Qiu Li Yang Xin-Xin Yu Jun Gu Cheng-Ran Xu; This work was supported by the National Key R&D Program of China(2019YFA0801500);the National Basic Research Program of China(2015CB942800);the National Natural Science Foundation of China(31521004,31471358,and 31522036);funding from Peking-Tsinghua Center for Life Sciences.; Defining the precise regionalization of specified definitive endoderm progenitors is critical for understanding the mechanisms underlying the generation and regeneration of respiratory and digestive organs,yet the pat...; 关键词：ORGANS PRECISE specified

Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis被引量：76: 《Cell Research》2017年第10期1216-1230,共15页Zhen Lin Phillip J Hsu Xudong Xing Jianhuo Fang Zhike Lu Qin Zou Ke-Jia Zhang Xiao Zhang Yuchuan Zhou Teng Zhang Youcheng Zhang Wanlu Song Guifang Jia Xuerui Yang Chuan He Ming-Han Tong; M-HT was supported by the Strategic Priority Research Pro- gram of the Chinese Academy of Sciences （XDB19000000）, the Ministry of Science and Technology of China （2014CB943101）, the National Key Research and Development Program of China （2016YFC1000600）, SIBS foundation, the National Natural Science Foundation of China （31471401 and 31671553）, the Science and Technology Commission of Shanghai Municipality （14140901502 and 14JC1407100）. This work was also supported by NIH HG008688 （CH）. CH is an investigator of the Howard Hughes Medical Institute. XY was supported by the National Natural Science Foundation of China （81472855 and 91540109）, the Ministry of Science and Technology of China Grant （2016YFC0906001）. We thank the Histology, Flow Cytometry and Vivarium services at SIBCB, and the Genome Sequencing and High-performance Computing services from the National Protein Science Facility （Beijing） at Tsinghua University.; Spermatogenesis is a differentiation process during which diploid spermatogonial stem cells （SSCs） produce hap- loid spermatozoa. This highly specialized process is precisely controlled at the transcriptional, postt...; 关键词：m6A RNA modification Mettl3 Mettll4 spermatogonial stem cell SPERMIOGENESIS

Pro-inflammatory effects of a litchi protein extract in murine RAW264.7 macrophages被引量：2: 《Horticulture Research》2016年第1期219-225,共7页Xiaoli Wang Xiaorong Hu Huiqing Yan Zhaocheng Ma Xiuxin Deng; This work was supported by the Special Fund for Agro-scientific Research in the Public Interest(No.201403036);the Fundamental Research Funds for the Central Universities(2014PY030);the National Basic Research Program of China(2011CB100600);the National NSF of China and the Foundation for the Key Program of the Ministry of Education,China(311029).; It has been observed that the consumption of litchi often causes symptoms characterized by itching or sore throat,gum swelling,oral cavity ulcers and even fever and inflammation,which significantly impair the quality ...; 关键词：RAW264.7 INFLAMMATORY INFLAMMATION

Maintenance and induction of murine embryonic stem cell differentiation using E-cadherin-Fc substrata without colony formation: 《Frontiers of Materials Science》2013年第1期51-61,共11页Qing-Yuan MENG Toshihiro AKAIKE

Impact of psychosocial stress on airway inflammation and its mechanism in a mUrine model of allergic asthma被引量：3: 《Chinese Medical Journal》2013年第2期325-334,共10页LI Bei DUAN Xiao-hong WU Jin-feng LIU Bao-jun LUO Qing-li JIN Hua-liang DU Yi-jie ZHANG Hong-ying CAO Yu-xue DONG Jing-cheng; Background It has already been recognized that psychosocial stress evokes asthma exacerbation; however, the mechanism of how stress gets inside the body is not clear. This study aimed to observe the impact of psychoso...; 关键词：psychosocial stress asthma glucocorticoid insensitivity glucocorticoid receptor

SAHA, an HDAC inhibitor, synergizes with tacrolimus to Prevent murine cardiac allograft rejection被引量：1: 《Cellular & Molecular Immunology》2012年第5期390-398,共9页Xin Zhang Shu Hann Yindong Kang Meng Guo Shanjuan Hong Fang Liu Shangxi Fu Liming Wang Quan-Xing Wang; ACKNOWLEDGEMENTS This work was supported by grants from the National Key Basic Research Program of China （2009CB522402） and the National Natural Science Foundation of China （31170856, U0832009 and 30772046）.; Suberoylanilide hydroxamic acid （SAHA）, as a histone deacetylase （HDAC） inhibitor （HDACi）, was recently found to exhibit an immunosuppressive effect. However, whether SAHA can synergize with calcineurin inhibito...; 关键词：allograft rejection HDAC inhibitor Th17 TREG

In-line X-ray phase-contrast imaging of murine liver microvasculature ex vivo被引量：5: 《Nuclear Science and Techniques》2012年第1期10-14,共5页LI Beilei XU Min WU Weizhong PENG Guanyun ZHANG Xi PENG Yifeng SHI Hongcheng CHEN Shaoliang; Supported by National Basic Research Program of China (973 Program Grant No.2010CB834305); Imaging blood vessels is of importance for determining the vascular distribution of organs and tumors.Phase-contrast X-ray imaging can reveal the vessels in much more detail than conventional X-ray absorption method.V...; 关键词：X射线成像相衬成像微血管体外小鼠上海同步辐射装置肿瘤血管生成生理盐水

Inactivation of mammalian target of rapamycin （mTOR） by rapamycin in a murine model of lipopolysaccharide-induced acute lung injury被引量：13: 《Chinese Medical Journal》2011年第19期3112-3117,共6页WANG Lan GUI Yao-song TIAN Xin-lun CAI Bai-qiang WANG De-tian ZHANG Dong ZHAO He XU Kai-feng; Background The mammalian target of rapamycin （mTOR） pathway, a key cellular signaling pathway associated with various cellular functions, has distinct roles in the inflammatory process. In this study, the mTOR inhib...; 关键词：mammalian target of rapamycin complex 1 RAPAMYCIN acute lung injury LIPOPOLYSACCHARIDE

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