CASTICIN

作品数：11被引量：51H指数：5
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相关领域：医药卫生更多>>
相关作者：龙灵芝周玲曹晓诚刘杰田莉更多>>
相关机构：湖南师范大学南方医科大学南方医院南华大学南方医科大学更多>>
相关期刊：《Acta Biochimica et Biophysica Sinica》《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金湖南省卫生厅中医药科研基金更多>>
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Casticin Attenuates Stemness in Cervical Cancer Stem-Like Cells by Regulating Activity and Expression of DNMT1被引量：2
《Chinese Journal of Integrative Medicine》2023年第3期224-232,共9页WANG Xue-li CAO Xiao-zheng WANG Dao-yuan QIU Ye-bei DENG Kai-yu CAO Jian-guo LIN Shao-qiang XU Yong REN Kai-qun 
Supported by the National Natural Science Foundation of China(No.82074075);Scientific Research Fund of Hunan Provincial Education Department(No.20C1340);the Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province,Hunan Normal University(No.2017TP1020);the Huxiang High-Level Talent Innovation Team(No.2018RS3072)。
Objective:To explore whether casticin(CAS)suppresses stemness in cancer stem-like cells(CSLCs)obtained from human cervical cancer(CCSLCs)and the underlying mechanism.Methods:Spheres from He La and Ca Ski cells were us...
关键词：cervical cancer cancer stem cell CASTICIN DNA methyltransferase 1 therapeutic action 
Casticin from Vitex species: a short review on its anticancer and anti-inflammatory properties被引量：7
《Journal of Integrative Medicine》2018年第3期147-152,共6页Eric Wei Chiang Chan Siu Kuin Wong Hung Tuck Chan 
This short review provides an update of the anticancer and anti-inflammatory properties of casticin from Vitex species. Casticin is a polymethylflavone with three rings, an orthocatechol moiety, a double bond,two hydr...
关键词：VITEXICARPIN Polymethylflavone Apoptosis Molecular mechanisms 
Casticin suppresses self-renewal and invasion of lung cancer stem-like cells from A549 cells through down-regulation of pAkt被引量：5
《Acta Biochimica et Biophysica Sinica》2014年第1期15-21,共7页Fei Liu Xiaozheng Cao Zhihong Liu Hui Guo Kaiqun Ren Meifang Quan Yuan Zhou Honglin Xiang Jianguo Cao 
A subpopulation of cancer stem cells is recognized as the cause of tumorigenesis and spreading. To investigate the effects of casticin （5,3＇-dihydroxy-3,6,7,4＇-tetramethoxyflavone）, derived from Fructus Viticis Si...
关键词：lung cancer CASTICIN cancer stem cells PAKT therapeutic action 
The flavonoid casticin enhances TRAIL-induced apoptosis of colon cancer cells through endoplasmic reticulum stress-mediated up-regulation of DR5
《The Chinese-German Journal of Clinical Oncology》2013年第6期279-284,共6页Sanyuan Tang Guangjin Yuan Zhengyang Yu Leilan Yin Hao Jiang 
Objective： The aim of this study was to explore the mechanisms by which the flavonoid casticin enhances tumor necrosis factor-related apoptosis-inducing ligand （TRAIL）-induced apoptosis in colon cancer cells. Meth...
关键词：CASTICIN tumor necrosis factor-related apoptosis-inducing ligand （TRAIL） apoptosis endoplasmic reticulum（ER） stress death receptor 5 （DR5） colon cancer 
Casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer cells被引量：11
《Asian Pacific Journal of Tropical Medicine》2013年第5期372-378,共7页Yuan Zhou Yi Peng Qi-Qi Mao Xia Li Ming-Wu Chen Ting Su Li Tian Nai-Quan Mao Ling-Zhi Long Mei-Fang Quan Fei Liu Su-Fang Zhou Yong-Xiang Zhao 
supported,in part,by grants from the National Natural Scientific Foundation of China(Nos.30760248, 81072161,81172139,81060183);Programs for Changjiang Scholars and Innovative Research Team in University(No. IRT1119);Programs for Guangxi Innovative Research Team (No.2011GXNSFF018005);Program of Science and Technology of Guangxi(No.1140003A-16);Project of Scientific Research of Hunan Province the Administration Bureau of Traditional Chinese Medicine(No.2010081);the Project of Scientific Research of Hunan Province the Department of Education (No.10C0975;Major Project of Scientific Research of Hunan Province the Department of Education(No.09A054)
Objective:To assess if casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer ceils.Methods:Human non-small-cell lung carcinoma cell lines H460...
关键词：LUNG cancer CASTICIN Apoptosis CYTOCHROME c p53 DR5 
Casticin combination with Cisplatin in sub-toxic concentration induced apoptosis of human ovarian cancer HO-8910 cells in vitro被引量：3
《The Chinese-German Journal of Clinical Oncology》2013年第1期35-39,共5页Jun Bai Guihuang Tan Li Chen Yingxia Ning 
Supported by a grant from the Hunan Provincial Education Department(No.2011.91.11C1109)
Objective: The aim of the study was to investigate the effect of Casticin (CAS) combination with Cisplatin (DDP) in sub-toxic concentration on apoptosis of human ovarian cancer HO-8910 cells in vitro and unravel the a...
关键词：ovarian cancer CAS DDP bcl-2 caspase-3 apoptosis 
Induction of apoptosis by casticin in cervical cancer cells： reactive oxygen species-dependent sustained activation of Jun N-terminal kinase被引量：10
《Acta Biochimica et Biophysica Sinica》2012年第5期442-449,共8页Fanxiang Zeng Li Tian Fei Liu Jianguo Cao Meifang Quan Xifeng Sheng 
Casticin, a polymethoxyflavone from Fructus viticis used as an anti-inflammatory agent in Chinese traditional medi- cine, has been reported to have anti-cancer activity. The purpose of this study was to examine the ap...
关键词：human cervical cancer CASTICIN APOPTOSIS reactive oxygen species c-Jun N-terminal kinase 
Casticin对宫颈癌细胞凋亡和线粒体凋亡途径的影响
《中南医学科学杂志》2011年第6期619-621,共3页刘杰 田莉 曹晓诚 盛习锋 
湖南省卫生厅医药科研项目(No.B2007-116);衡阳市科学技术发展计划项目(2010KJ39)
目的探讨紫花牡荆素(Casticin,CAS)是否通过线粒体凋亡途径诱导人宫颈癌HeLa细胞凋亡。方法体外培养人宫颈癌HeLa细胞。ELISA法检测细胞组蛋白/DNA碎片;碘化丙啶(propidium iodide,PI)染色流式细胞术(flow cytometry,FCM)分析细胞凋亡率...
关键词：宫颈癌 紫花牡荆素 线粒体膜电位 半胱天冬酶 
Casticin-induced apoptosis involves death receptor 5 upregulation in hepatocellular carcinoma cells被引量：22
《World Journal of Gastroenterology》2011年第38期4298-4307,共10页Jun Yang Yun Yang Li Tian Xi-Feng Sheng Fei Liu Jian-Guo Cao 
Supported by The Scientifi c Research Project of Hunan Provincial Administration Bureau of Traditional Chinese Medicine,No. 2010081;Scientific Research Project of Hunan Provincial Health Department,No. B2010-030;Major Projects of Scien-tific Research of Hunan Provincial Department of Education,No. 09A054
AIM:To investigate the apoptotic activities of casticin in hepatocellular carcinoma(HCC) cells and its molecular mechanisms.METHODS:PLC/PRF/5 and Hep G2 cell lines were cultured in vitro and the inhibitory effect of c...
关键词：Hepatocellular carcinoma CASTICIN GLUTATHIONE Death receptor 5 
Proliferation inhibition of human cervical cancer HeLa cells by Casticin in vitro被引量：1
《The Chinese-German Journal of Clinical Oncology》2011年第1期47-50,共4页Jing Xie Jun Bai Xifeng Sheng Jianguo Cao Wanyu Xie 
Supported by a grant from Hunan Provincial Health Department Research Fund (No.B2007-116)
Objective： The aim of the study was to investigate the effect of Casticin on proliferation inhibition of human cervical cancer HeLa cells in vitro and to unravel the associated mechanisms. Methods： Human cervical He...
关键词：cervical cancer CASTICIN cyclin B1 P21 PROLIFERATION 
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