supported by Suzhou Special Project on Clinical Key Diseases Treatment Technology of Suzhou Commission of Health(No.LCZX201803);People’s Livelihood and Science and Technology project of Department of Science and Technology of Suzhou(No.SS2019059);Jiangsu Provincial Medical Key Discipline(No.ZDXK202246);Key Project of Jiangsu Provincial Health Commission(No.zd2021050);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(No.20KJA310005);Key Project of Medical Research of Jiangsu Commission of Health(No.ZDA2020008);National Natural Science Foundation of China(No.81802843);Social Development Project of Department of Science and Technology of Jiangsu Province(No.BE2019667)
Background:Cancer stem-like cells(CSCs)are a small subset of cells in tumors that exhibit self-renewal and differentiation properties.CSCs play a vital role in tumor formation,progression,relapse,and therapeutic resis...
We previously reported that intranasal insulin protects substantia nigra dopaminergic neurons against6-hydroxydopamine neurotoxicity in rats. This study aimed to assess insulin pharmacokinetics in the rat brain follow...