NON-PEPTIDE

作品数：6被引量：7H指数：2
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A non-peptide-based chymotrypsin-targeted long-wavelength emission fluorescent probe with large Stokes shift and its application in bioimaging
《Chinese Chemical Letters》2024年第10期430-436,共7页Chuanfeng Fan Jian Gao Yingkai Gao Xintong Yang Gaoning Li Xiaochun Wang Fei Li Jin Zhou Haifeng Yu Yi Huang Jin Chen Yingying Shan Li Chen 
financial support provided by National Natural Science Foundation of China(Nos.21775005,41430641 and 41140032);the Start-Up Fund of Qingdao University of Science and Technology(No.12030430010883)。
As a hydrolase,chymotrypsin(CHT)is involved in many physiological activities,and its abnormal activity is closely related to diabetes,pancreatic fibrosis,chronic pancreatitis and pancreatic cancer.In this work,an inno...
关键词：CHYMOTRYPSIN Fluorescent probe Long-wavelength emission Large Stokes shift BIOIMAGING 
Structures of the endogenous peptide-and selective non-peptide agonist-bound SSTR2 signaling complexes被引量：3
《Cell Research》2022年第8期785-788,共4页Li-Nan Chen Wei-Wei Wang Ying-Jun Dong Dan-Dan Shen Jia Guo Xuefei Yu Jiao Qin Su-Yu Ji Huibing Zhang Qingya Shen Qiaojun He Bo Yang Yan Zhang Qinglin Li Chunyou Mao 
supported by the National Natural Science Foundation of China(81922071 to Y.Z.and 32100959 to C.M.);Zhejiang Province Natural Science Fund for Excellent Young Scholars(LR19H31000 to Y.Z.and LR22C050002 to C.M.);the Ministry of Science and Technology(2019YFA050880 to Y.Z.);the Key R&D Projects of Zhejiang Province(2021C03039 to Y.Z.).
Dear Editor,Somatostatin,also known as growth hormone-inhibiting hormone,is an important peptide hormone that mediates predominanty neuroendocrine inhibitory effects in the exocrine and endocrine systems,12 Besides,t ...
关键词：COMPLEXES ANALOGS predominant 
Potential PET Ligands for Imaging of Cerebral VPAC and PAC Receptors: Are Non-Peptide Small Molecules Superior to Peptide Compounds?被引量：1
《World Journal of Neuroscience》2015年第5期364-384,共21页Margit Pissarek 
Pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) have been known for decades to mediate neuroendocrine and vasodilative actions via G-protein-coupled receptors of Clas...
关键词：Class B RECEPTORS Vasoactive Intestinal PEPTIDE Pituitary ADENYLATE Cyclase Activating Polypeptide NON-PEPTIDE LIGANDS PET SPECT 
Synthesis and biological evaluation of novel phenothiazine derivatives as non-peptide arginine vasopressin V2 receptor antagonists
《Chinese Chemical Letters》2015年第5期627-630,共4页Shuang Zhi Shuai Mu Ying Liu Min Gong Ping-Bao Wang Deng-Ke Liu 
supported by National Major Scientific and Technological Special Project for "Significant New Drugs Development"(Nos.2011ZX09401-009 and 2013ZX09102014)
A series of novel phenothiazine derivatives was synthesized and tested for arginine vasopressin receptor antagonist activity. They were synthesized as novel arginine vasopressin receptor antagonists from phenothiazine...
关键词：Arginine vasopressin V2 receptor antagonist Phenothiazine derivatives Synthesis Biological activities 
Non-peptide ligands in the characterization of peptide receptors at the interface between neuroendocrine and mental diseases被引量：2
《World Journal of Neuroscience》2013年第2期100-125,共26页Margit Pissarek Ulrich Disko 
Hypothalamic receptors for neuropeptide Y, melaninconcentrating hormone, melanocortins and orexins/ hypocretins as well as for the downstream signaling corticotrophic factor have been discussed broadly for their influ...
关键词：FEEDING Receptor HYPOTHALAMUS NEUROPEPTIDE NON-PEPTIDE ANTAGONIST PET SPECT 
Design and synthesis of 2-alkylbenzimidazole derivatives as novel non-peptide angiotensin Ⅱ AT1 receptor antagonists被引量：1
《Chinese Chemical Letters》2007年第3期251-254,共4页Jin Yi Xu Qian Ran Wei Yi Hua Xiao Ming Wu Qiu Juan Wang Jing Zhang 
We are thankful to the National Natural Science Foundation of China(No.30371688);Key Fund of Ministry of Education of China(No.03089)for financial support.
A series of 2-alkylbenzimidazole derivatives 9a-n have been designed and synthesized as a novel class of non-peptide angiotensin H AT1 receptor antagonists. The synthesized compounds were evaluated for their antagonis...
关键词：2-Alkylbenzimidazole AT1 receptor antagonists SYNTHESIS HYPERTENSION 
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