financial supports from the National Key R&D Program of China(grant nos.2022YFA1503702 and 2021YFF0701602);NSFC(grant nos.22231011 and 22271303).
Oxazolones are structural subunits in numerous natural products and designed molecules with substantial pharmacological properties.Here,a palladium-catalyzed chemodivergent regio-and enantioselective allylic alkylatio...
We thank the National Natural Science Foundation of China(NSF 22171114 and 21772075)for its financial support.
Efficiently modifying glycals by directly introducing functional groups into their double bonds is a longstanding challenge.Here,the strategy of introducing two different functional groups into 1-iodoglycals to obtain...
The research reported in this publication was supported by the National Institutes of Health(grant no.R35-GM119652 to M.-Y.N.and grant no.R35-GM128779 to P.L.);DFT calculations were performed at the Center for Research Computing at the University of Pittsburgh,PA,USA,the Texas Advanced Computing Center(TACC)Frontera supercomputer,TX,USA,and the Extreme Science and Engineering Discovery Environment(XSEDE),TX,USA,supported by the National Science Foundation,VA,USA,grant number ACI1548562;The Shimadzu ultraperformance liquid chromatography/mass spectrometry(UPLC/MS)used for portions of this work were purchased with funds from the National Institute of General Medical Sciences(NIGMS,MD,USA)equipment administrative supplement(grant no.R35-GM119652-04S1),Shimadzu Scientific Instruments grant,and Office of the Vice President for Research at Stony Brook University,NY,USA.
C-Glycosides are important carbohydrate mimetics found in natural products,bioactive compounds,and marketed drugs.However,stereoselective preparation of this class of glycomimetics remains a significant challenge in o...
We thank the National Natural Science Foundation of China(grant nos.22050005,21732004,and 21821001);the Tsinghua University Initiative Scientific Research Program(grant no.2019Z07L01004)for generous financial support.
Recent years have witnessed breakthroughs in the study of zigzag hydrocarbon belts.However,the synthesis of heterocycle-containing zigzag molecular belts remains very rare and challenging despite their interesting str...
supported by the NSFC(nos.21525207,21772147,and 220711186);the Huibei Province Natural Science Foundation(no.2020CFA036);Support by the Fundamental Research Funds for the Central Universities;the Program of Introducing Talents of Discipline to Universities of China(111 Program)is also appreciated.
We report an unprecedented Pd-catalyzed asymmetric allylic alkylation of 1-(indol-2-yl)cyclobutanols followed by anα-iminol rearrangement.High yields with excellent chemo-,regio-,diastereo-,and enantioselectivities h...
supported by the National Science Foundation of China(no.22071267);the National Science and Technology Major Project“Key New Drug Creation and Manufacturing Program,”China(no.2020ZX09201015);the Innovation Team of the“DoubleFirst Class Initiative”(nos.CPU2018GY04 and CPU2018GY35);the Foundation of the Open Project of State Key Laboratory of Natural Medicines(no.SKLNMZZ202023).
Many of the commonly used pharmaceuticals and biologically active natural products are nitrogencontaining compounds.Recently,the transitionmetal-catalyzed or the radical-mediated 1,2-carboamination of alkenes has been...
the National Key R&D Program of China(no.2016YFA0203102);the National Natural Science Foundation of China(nos.21577157,21777177,and 21822608)。
Palladium(Pd)-catalyzed cross-coupling reaction is a widely studied process with significant economic interest and represents one of the most successful nanocatalytic examples.Owing to the observed leaching of Pd ions...
supported by generous grants from the National Natural Science Foundation of China(nos.NSFC-21971204,21622203,and 21702161);the Innovation Capability Support Program of Shaanxi Province(no.2020TD-022).
Herein,we report a novel palladium(Pd)-catalyzed asymmetric domino Heck/carbocyclization/Suzuki reaction of N-(2-bromoaryl)-2-naphthylacrylamides.The reaction involves a novel and enantioselective dearomative 1,2-inse...
support from the National Natural Science Foundation of China(nos.21702184,21772175,and 91956117).
Highly enantioselective and diastereoselective 1,2-diarylation and 1,2-arylalkynylation of trisubstituted alkenes are reported via the palladium-catalyzed Heck/Suzuki or Heck/Sonogashira domino sequence.These alkenes ...
G.C.thanks NSFC-91753124,NSFC-21672105,NSFC-21421062,and NSFC-21725204 for financial support for this work.
Despite the significant progress in carbohydrate chemistry,there remains a pressing need for efficient and practical glycosylationmethods using simple glycosyl donors and with high atom economy.Herein,a new protocol f...