THREONINE

作品数：67被引量：203H指数：7
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Bromodomain-containing protein 4 knockdown promotes neuronal ferroptosis in a mouse model of subarachnoid hemorrhage
《Neural Regeneration Research》2026年第2期715-729,共15页Peng Lu Fan Zhang Lei Yang Yijing He Xi Kong Kecheng Guo Yuke Xie Huangfan Xie Bingqing Xie Yong Jiang Jianhua Peng 
supported by the National Natural Science Foundation of China,Nos.82371310(to YJ),82271306(to JP);the Sichuan Science and Technology Support Program,Nos.2023YFH0069(to JP),2023NSFSC0028(to YJ),2023NSFSC1559(to YJ),2022YFS0615(to JP),2022NSFSC1421(to JP);Scientific Research Project of Sichuan Provincial Health Commission,No.23LCYJ040(to YJ);Youth Foundation of Southwestern Medical University and Southwest Medical University Project,Nos.2020ZRQNA038(to JP),2021ZKZD013(to JP),2021LZXNYD-P01(to YJ),2023QN014(to JP).
Neuronal cell death is a common outcome of multiple pathophysiological processes and a key factor in neurological dysfunction after subarachnoid hemorrhage.Neuronal ferroptosis in particular plays an important role in...
关键词：bromodomain-containing protein 4 cell death early brain injury ferritinophagy ferroptosis neurological deficits neuron oxidative stress RAF proto-oncogene serine/threonine-protein kinase(Raf-1) subarachnoid hemorrhage 
基于“既病防变”脾肾同补法调控缺血性脑卒中PI3K/AKT通路相关蛋白表达的研究进展被引量：1
《辽宁中医杂志》2024年第12期215-220,I0023,共7页王羽 李文武 徐青云 朱潇 苗琦 雷烨 张怡敏 朱慧渊 
国家自然科学基金项目(82174268);中西医结合治疗糖尿病血管病变创新团队项目(2020XKTD-C01);陕西中医药大学校级研究生质量提升工程专项(CXSJ202316)。
缺血性脑卒中(ischemic stroke,IS)是一种由于脑局部血液供应不足导致的急性脑血管疾病,具有高致残率及致死率的特点。IS的发病机制复杂,涉及细胞凋亡、兴奋性中毒、能量代谢紊乱、氧化应激和炎症反应等方面。在脑缺血半暗带区域,细胞...
关键词：既病防变 脾肾同补 磷脂酰肌醇3-激酶(phosphoinositide-3 kinase PI3K)/蛋白激酶B(perine-threonine kinase Akt)通路 脑卒中 细胞凋亡 
Increasing concentrations of dietary threonine,tryptophan,and glycine improve growth performance and intestinal health with decreasing stress responses in broiler chickens raised under multiple stress conditions
《Animal Nutrition》2024年第3期145-153,共9页Hyun Woo Kim Jong Hyuk Kim Gi Ppeum Han Dong Yong Kil 
supported by Basic Science Research Program through the National Research Foundation of Korea (NRF)funded by the Ministry of Education (2021 R111A1 A010501414);supported by the Chung-Ang University Graduate Research Scholarship in 2023.
The current study aimed to compare the effects of increasing concentrations of dietary threonine(Thr),tryptophan(Trp),and glycine(Gly)on growth performance,stress biomarkers,and intestinal function in broiler chickens...
关键词：Broiler chicken GLYCINE Multiple stress THREONINE TRYPTOPHAN 
Higher intakes of lysine,threonine and valine are inversely associated with non-alcoholic fatty liver disease risk:a community-based case-control study in the Chinese elderly
《Food Science and Human Wellness》2024年第1期191-197,共7页Xueqi Li Wenjun Ma Ting Yang Chong Wang Wei Zhang Hui Li Ting Zhao Xiaofei Guo 
supported by National Natural Science Foundation of China(NSFC:82073538 and 81773433);by the 2018 Chinese Nutrition Society(CNS)Nutrition Research Foundation-DSM Research Fund(CNS-DSM2018A30)。
The associations of individual amino acid with non-alcoholic fatty liver disease(NAFLD)risk remained unclear.The present study aimed to investigate the associations between the two in the Chinese elderly.Methods:A com...
关键词：Amino acid Non-alcoholic fatty liver disease Senior citizen Dose-response analysis 
Determination of Carbon and Nitrogen Isotope Fractions in Asparagine, Aspartic Acid, Threonine and Methionine
《American Journal of Analytical Chemistry》2024年第1期30-42,共13页Lamzira Pharulava Levani Eliashvili Vakhtang Betlemidze Bachana Sulava 
The nomenclature for compounds that are modified with isotopes is growing every day. Compounds can be modified with isotopes either individually, in a functional group or groups, or completely with all atomic centers ...
关键词：ASPARAGINE Aspartic Acid THREONINE METHIONINE Mass Spectrometer Isotopic Analysis Atomic Share 
Improvement of the activity and thermostability of l‑threonine aldolase from Pseudomonas putida via tailoring of the active sites lining the binding pocket
《Systems Microbiology and Biomanufacturing》2023年第3期440-448,共9页Lihong Li Rongzhen Zhang Wenchi Zhang Yan Xu 
the National Key research and Development Program of China(2018YFA0900302);the National Science Foundation of China(32271487,31970045);the National Firstclass Discipline Program of Light Industry Technology and Engineering(LITE2018-12);the Program of Introducing Talents of Discipline to Universities(111-2-06);Top-notch Academic Programs Project of Jiangsu Higher Education Institutions.
l-threonine aldolases catalyze the conversion of glycine and aldehydes to synthesizeβ-hydroxy-α-amino acids with unsatisfactory enzyme activity.Here,we expressed the l-threonine aldolase from Pseudomonas putida KT24...
关键词：Threonine aldolases Pseudomonas putida Catalytic efficiency Thermostability Molecular dynamics simulations 
In situ synthesized homochiral dysprosium-oxo clusters with threonine Schiff bases
《Chinese Chemical Letters》2023年第8期458-461,共4页Song Peng Xiaoming Ouyang Yihan Wang Qinghu Teng Yan Li Xiuqing Zhang Zhaobo Hu Kai Wang Fupei Liang 
This work was financially supported by the National Natural Science Foundation of China(Nos.21961008,22271068,22075058 and 22261012);Guangxi Science and Technology Base and Talents Program(No.AD21220105);Guangxi Natural Science Foundation(No.2022GXNSFBA035472).
Chiral high-nuclearity lanthanide(4f)clusters have shown fantastic properties in various fields.However,their synthesis is still of great challenge.Herein,we report two pairs of enantiomers of highnuclearity Dy-oxo cl...
关键词：CHIRALITY Lanthanide-oxo cluster In situ synthesis Threonine Schiff bases Hydrolysis Magnetic properties 
Proteomic and phosphoproteomic analysis reveal threonine deficiency increases hepatic lipid deposition in Pekin ducks via reducing STAT phosphorylation
《Animal Nutrition》2023年第2期249-260,共12页Yong Jiang Zhong Zhuang Wenqia Jia Zhiguo Wen Ming Xie Hao Bai Yulin Bi Zhixiu Wang Guobin Chang Shuisheng Hou Guohong Chen 
supported by National Natural Science Foundation of China(31902174);Natural Science Foundation of Jiangsu Province(BK20190902);Tackled key technologies in agriculture and rural areas of Jiangsu Science and Technology Plan(BE2022310).
Dietary threonine(Thr)deficiency enhances triglyceride(TG)deposition in the liver of Pekin ducks,which injures hepatic function and impairs growth performance.However,the underlying molecular mechanisms remain unclear...
关键词：Threonine deficiency Triglyceride accumulation PROTEOMIC Phosphoproteomic Pekin duck 
Dietary threonine deficiency affects expression of genes involved in lipid metabolism in adipose tissues of Pekin ducks in a genotype-dependent manner被引量：2
《Journal of Integrative Agriculture》2022年第9期2691-2699,共9页JIANG Yong MA Xin-yan XIE Ming ZHOU Zheng-kui TANG Jing CHANG Guo-bin CHEN Guo-hong Hou Shui-sheng 
supported by the National Natural Science Foundation of China(31902174);the Natural Science Foundation of Jiangsu Province,China(BK20190902);the Natural Science Foundation of Jiangsu Higher Education Institutions of China(19KJD230003)。
Dietary threonine(Thr) deficiency increases hepatic triglyceride content and reduces sebum and abdominal fat percentages in lean type(LT), but not in fatty type(FT) Pekin ducks. However, the molecular changes regardin...
关键词：THREONINE lipid metabolism gene expression Pekin ducks 
Loss of O-GlcNAcylation on MeCP2 at Threonine 203 Leads to Neurodevelopmental Disorders
《Neuroscience Bulletin》2022年第2期113-134,共22页Juanxian Cheng Zhe Zhao Liping Chen Ying Li Ruijing Du Yan Wu Qian Zhu Ming Fan Xiaotao Duan Haitao Wu 
supported by the National Natural Science Foundation of China(31770929 and 31522029);the Beijing Municipal Science and Technology Commission(Z181100001518001 and Z161100000216154)of China.
Mutations of the X-linked methyl-CpG-binding protein 2(MECP2)gene in humans are responsible for most cases of Rett syndrome(RTT),an X-linked progressive neurological disorder.While genome-wide screens in clinical tria...
关键词：MECP2 O-GlcNAcylation-Dendrite development Synaptic transmission Braiderived neurotrophic factor 
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