云南高校图书馆联盟文献共享服务平台- DNAZYMES

DNAZYMES: 作品数：11被引量：17H指数：3; 导出分析报告; 相关领域：医药卫生理学更多>>; 相关作者：李文钊吴雷李正强李敏伟张国如更多>>; 相关机构：江苏海洋大学吉林大学南华大学海南省第三人民医院更多>>; 相关期刊：《Science China Chemistry》《World Journal of Gastroenterology》《南华大学学报（自然科学版）》《Chemical Research in Chinese Universities》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划海南省自然科学基金国家高技术研究发展计划更多>>

Functional nucleic acid-based biosensors for virus detection: 《Advanced Agrochem》2023年第3期246-257,共12页Zijie Zhang Bal Ram Adhikari Payel Sen Leyla Soleymani Yingfu Li; supported by the Natural Science and Engineering Research Council(NSERC)of Canada.L.S.is supported by the Canada Research Chair program.; A growing number of viruses pose significant threats to human health,impact agricultural production and compromise food safety.Minimizing the impact of viral infections demands for effective technologies that can deli...; 关键词：Functional nucleic acids Biosensors Aptamers DNAZYMES Viruses Infectious diseases

A pH-regulated stimuli-responsive strategy for RNA-cleaving DNAzyme被引量：1: 《Science China Chemistry》2020年第3期404-410,共7页Shasha Lu Shuang Wang Jiahui Zhao Jian Sun Xiurong Yang; supported by the National Natural Science Foundation of China(21721003,21435005,21627808,21605139);the Key Research Program of Frontier Sciences,Chinese Academy of Sciences(QYZDY-SSW-SLH019);the Youth Innovation Promotion Association,Chinese Academy of Sciences(2018258).; RNA-cleaving DNAzymes possess important roles in DNAzymes and have been widely used in the biosensors,DNA nanomachines owing to their ion-specific dependence.However,there are still challenges in constructing universa...; 关键词：DNAZYMES HAIRPIN nanostructure TRIPLEX pH Pb2+ FRET

DNAzymes针对Ezrin mRNA的反义技术靶点筛选及验证: 《中国医药导报》2018年第36期8-11,共4页潘辉龙张国如王晋吴兴源; 海南省自然科学基金项目(310182);海南省三亚市医疗卫生科技创新项目(2015YW30); 目的分析肿瘤远处转移相关蛋白(Ezrin mRNA)的结构,寻找并验证DNAzymes作用的最佳靶点。方法利用RNAstructure与RNAdraw程序分析Ezrin mRNA结构,计算其一、二级结构,两种程序同时计算出碱基未配对的单链成环区,且连续存在4个以上,则将...; 关键词：EZRIN 反义技术靶点 DNAZYMES 二级结构

Recent advances in DNAzyme-based gene silencing被引量：5: 《Science China Chemistry》2017年第5期591-601,共11页Huanhuan Fan Xiaobing Zhang Yi Lu; supported by the National Key Scientific Program of China(2011CB911000);the National Basic Research Program of China(2013CB932702);the National Natural Science Foundation of China(21325520,21327009,J1210040,21177036);the National Instrumentation Program(2011YQ030124);the Foundation for Innovative Research Groups of NSFC(21521063); DNAzymes, generated through in vitro selection processes, are single-stranded DNA catalysts that can catalyze a wide variety of reactions, such as RNA or DNA cleavage and ligation or DNA phosphorylation. Based on spec...; 关键词：DNAZYMES GENE-SILENCING delivery STABILITY COFACTORS

介孔硅材料组装DNA电化学生物膜电极的制备被引量：1: 《南华大学学报（自然科学版）》2017年第1期85-90,共6页文艺袁亚莉李乐廖琪侯少岩; 国家自然科学基金项目(11405081);湖南省科技厅项目(2014FJ6097); 利用马来酰亚胺基类酯(Sulfo-SMCC)为异双功能偶联剂,将巯基修饰好的DNAzyme共价固定在已负载亚甲基蓝的氨基化介孔二氧化硅纳米材料上,并将壳聚糖混合后滴涂至碳糊电极表面上形成了电化学生物传感膜.利用循环伏安法、电化学阻抗法等对...; 关键词：二氧化硅纳米材料 DNAZYMES 亚甲基蓝电化学生物膜电极

pH-controlled DNAzymes： Rational design and their applications in DNA-machinery devices被引量：1: 《Nano Research》2016年第10期3084-3092,共9页Yuqi Chen Yanyan Song Zhiyong He Zijing Wang Wenting Liu FuanWang Xiaolian Zhang Xiang Zhou; The authors thank the National Basic Research Pro- gram of China （973 Program）（Nos. 2012CB720600, 2012CB720603, and 2012CB720604）, the National Natural Science Foundation of China （Nos. 21432008 and 81373256）.; The availability and reliability of strategies for molecular biosensing over a finely adjustable dynamic range is essential to enhance the understanding and control of vital biological process. To expand the versatili...; 关键词：pH iMNAzyme TNAzyme DNA walker DNA tetrahedron

骨肉瘤中DNAzymes针对ezrin mRNA作用靶点筛选及体外验证: 《海南医学》2013年第20期2965-2967,共3页张国如王晋王姚斐陈运崇杜秀藩; 海南省自然科学基金(编号:310182); 目的对Ezrin mRNA的4个DNAzymes靶点AU1655、AU1751、AU1766、AU1789通过体外实验进行验证,寻找最佳的作用位点。方法同时使用RNAdraw、RNAstructure和OligoWalk 3个程序对Ezrin mRNA的DNAzymes靶点进行了设计和筛选,对最终选出的4个位...; 关键词：EZRIN 靶点 DNAZYMES 二级结构

Use of DNAzymes for cancer research and therapy被引量：3: 《Chinese Science Bulletin》2012年第26期3404-3408,共5页XU ZhiJie YANG LiFang SUN LunQuan CAO Ya; supported by the National Natural Science Foundation of China (30873010 and 81072220);the National High Technology Research and Development Program of China (2009AA02Z403); DNAzymes(Dzs) are single-stranded DNA catalysts that specifically cleave the mRNA of targeted genes.Compared with other gene-silencing technologies,such as ribozymes,antisense oligonucleotide and small interference RN...; 关键词：脱氧核酶治疗癌症小干扰RNA 分子生物技术心血管疾病反义寡核苷酸病毒性传染病

一种新型脱氧核酶G-quadruplexe—DNAZYMES的构效关系研究: 《生物物理学报》2009年第S1期344-344,共1页李正强吴雷李文钊孙宇; 1962年DavidR.Davies首先发现富含鸟嘌呤的核酸分子可以通过hoogsteen氢键作用,形成一种由几个G-quarter片层堆叠构成的四链DNA结构,即G-quadruplexe结构。; 关键词：G-QUADRUPLEXE 脱氧核酶 Tmpyp4 卟啉

Inhibition of Ampicillin-resistance in Bacteria by Modified DNAzymes: 《Chemical Research in Chinese Universities》2008年第4期491-495,共5页CHEN Fei LI Zhe YANG Shuo WANG Rui-jian LIU Bin SONG Yu-ming SUN Yan-hong HAO Dong-yun WANG Xiao-ping; the National Natural Science Foundation of China(Nos.20771030 and 20671025); To overcome ampicillin-resistance of bacteria which is believed to attribute their endogenous B-lactamase, we designed three 10-23 DNAzymes（Dz1, Dz2. Dz3） targeting the coding region of B-lactamase mRNA and examined...; 关键词：DNAZYME DRUG-RESISTANCE Β-LACTAMASE AMPICILLIN Antisense drug

DNAZYMES