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Dysfunctional glucose metabolism triggers oxidative stress to induce kidney injury in diabetes
《World Journal of Diabetes》2025年第4期19-24,共6页Meng Gao Meng-Ting Dai Guo-Hua Gong 
Supported by The Basic Research Project of Wenzhou Municipal Science and Technology Bureau,No.Y20240008;The Medical Health Science and Technology Project of Zhejiang Provincial Health Commission,No.2024KY138;The Key Laboratory of School of Laboratory Medicine and Life Sciences,Wenzhou Medical University of China,No.JS2023003。
In this editorial,we discussed the article published in the recent issue of the World Journal of Diabetes.To understand the effect of mizagliflozin on kidney injury induced by diabetes,we focused on the mechanisms by ...
关键词：Glucose metabolism Sodium-D-glucose cotransporter 1 Glucose reabsorption Mitochondrial dysfunction Reactive oxygen species Inflammation 
Insulin-induced severe thyrotoxic periodic paralysis:A case report
《World Journal of Clinical Cases》2025年第7期46-51,共6页Yan-Li Wang Jian Li 
BACKGROUND Thyrotoxic periodic paralysis(TPP)is an endocrine emergency caused by thyrotoxicosis,manifesting mainly as periodic myasthenia and hypokalemia,and posing a serious threat to the patient's health.Fatigue,str...
关键词：Thyrotoxic periodic paralysis Potassium metabolism disorders INSULIN Triggers of paralysis Case report 
Elevated CXCL1 triggers dopaminergic neuronal loss in the substantia nigra of C57BL/6J mice:Evaluation of a novel Parkinsonian mouse model
《Zoological Research》2025年第1期225-235,共11页Xi-Zhen Ma Guo-Rui Jia Meng-Yu Li Sheng-Han Zhang Zhao-Xin Wang Ning Song Ying-Juan Liu Jun-Xia Xie 
supported by the National Natural Science Foundation of China (32471049,32170984,32471188,32200802);Natural Science Foundation of Shandong Province (ZR2023QH110)。
Substantial evidence points to the early onset of peripheral inflammation in the development of Parkinson's disease(PD),supporting the“body-first”hypothesis.However,there remains a notable absence of PD-specific ani...
关键词：Parkinson’s disease Mouse model CXCL1 Inflammation PPAR signaling pathway 
Magnaporthe oryzae infection triggers rice resistance to brown planthopper through the influence of jasmonic acid on the flavonoid biosynthesis pathway
《Insect Science》2025年第1期243-259,共17页Su Chen Zhihuan Tao Yanjie Shen Rui Yang Siyuan Yan Zixu Chen Bo Sun Xiaofang Yang 
supported by the Faculty Startup Fund for CS from Jining Medical University and by Shandong Provincial Natural Science Foundation(ZR2023QC309).
In agroecosystems,plants are constantly exposed to attack from diverse herbivorous insects and microbes,and infestation with one species may change the plant defense response to other species.In our investigation of t...
关键词：flavonoid jasmonic acid Nilaparvata lugens RICE rice blast 
A mitochondria targeting Ir(Ⅲ)complex triggers ferroptosis and autophagy for cancer therapy:A case of aggregation enhanced PDT strategy for metal complexes
《Chinese Chemical Letters》2025年第1期374-380,共7页Panpan Wang Hongbao Fang Mengmeng Wang Guandong Zhang Na Xu Yan Su Hongke Liu Zhi Su 
support from the National Natural Science Foundation of China(Nos.22277056,21977052);the Distinguished Young Scholars of Jiangsu Province(No.BK20230006);the Natural Science Foundation of Jiangsu Province(Nos.BK20230977,BK20231090);the Natural Science Foundation of the Higher Education Institutions of Jiangsu Province(No.23KJB150020);the Jiangsu Excellent Postdoctoral Program(No.2022ZB758)。
Metal complexes hold significant promise in tumor diagnosis and treatment.However,their potential applications in photodynamic therapy(PDT)are hindered by issues such as poor photostability,low yield of reactive oxyge...
关键词：Metal complex AIEgens Mitochondria targeting Enhanced photodynamic therapy Anticancer agent 
Suggested Work Modifications for Patients with Environmental and Occupational Risk Factors in Hidradenitis Suppurativa
《Occupational Diseases and Environmental Medicine》2024年第4期305-317,共13页Kelly Frasier Mary Grace Hash Alyssa Forsyth Christina Randolph Guang Orestes Raquel Batista 
Hidradenitis suppurativa (HS) is a chronic, inflammatory skin condition characterized by painful nodules, abscesses, and scarring, primarily affecting areas rich in apocrine glands. Environmental and occupational risk...
关键词：Hidradenitis Suppurativa Occupational Risk Factors Work Environment Modifications Heat and Friction Exposure Ergonomic Adjustments Chemical Irritants Preventative Strategies Workwear for HS Environmental Triggers Dermatology and Occupational Health Collaboration 
Effects of triggers of senescence and senolysis in murine pancreatic cancer cells
《Hepatobiliary & Pancreatic Diseases International》2024年第6期628-637,共10页Denis Revskij Aline Woitas Bianca Kölle Camilla Umstätter Dietmar Zechner Faiz M Khan Georg Fuellen Robert Jaster 
supported by a grant from the Bundesministerium fur Bildung und Forschung(01ZX1903A).
Background:The combination of senescence triggers with senolytic drugs is considered a promising new approach to cancer therapy.Here,we studied the efficacy of the genotoxic agent etoposide(Eto)and irradiation in indu...
关键词：Pancreatic cancer Panc02 cells ETOPOSIDE IRRADIATION Navitoclax 
Hydrogen-Bonded Supramolecular Network Triggers High-Efficiency Blue Room-Temperature Phosphorescence
《CCS Chemistry》2024年第11期2727-2740,共14页Sen Wu Tao Wang Eli Zysman-Colman 
S.W.thanks the China Scholarship Council(grant no.201906250199)for support;funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No.897098(AIERTP-PLED);support from the Marie Skłodowska-Curie Individual Fellowship;We also thank the United Kingdom’s Engineering and Physical Sciences Research Council for support(grant no.EP/W007517/1).
Hydrogen bonding has been employed to suppressnonradiative decay in organic compounds that showroom-temperature phosphorescence (RTP);however, the small number of structurally diverse examplesmakes it unclear how gene...
关键词：room-temperature phosphorescence blue phosphorescence 4 4′ 4′′-nitrilotribenzoic acid hydrogen bonding supramolecular networks 
A novel secreted protein FgHrip1 from Fusarium graminearum triggers immune responses in plants
《Journal of Integrative Agriculture》2024年第11期3774-3787,共14页Zhenchao Fu Huiqian Zhuang Vincent Ninkuu Jianpei Yan Guangyue Li Xiufen Yang Hongmei Zeng 
financed by the National Key Research and Development Program of China(2017YFD0200900)。
Fusarium graminearum,the primary pathogenic fungus responsible for Fusarium head blight(FHB)in wheat,secretes abundant chemical compounds that interact with host plants.In this study,a secreted protein FgHrip1,isolate...
关键词：FgHrip1 secreted protein PLANT IMMUNITY Fusarium graminearum WHEAT 
GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia
《Signal Transduction and Targeted Therapy》2024年第10期4667-4682,共16页Xu Chen Qingnan Wu Wei Gong Shaolong Ju Jiawen Fan Xiaohan Gao Xingyang Liu Xiao Lei Siqi Liu Xiangdong Ming Qianyu Wang Ming Fu Yongmei Song Yan Wang Qimin Zhan 
National Key Research and Development Program of China#1 under Y.W.[number 2022YFC3400904];National Natural Science Foundation of China#2 under Q.Z.[number 81988101 and 81830086];National Natural Science Foundation of China#3 under Y.W.[number 82173152];Research Unit of Molecular Cancer Research,Chinese Academy of Medical Sciences,CAMS Innovation Fund for Medical Sciences#4 under Q.Z.[number 2019-I2M-5-081];Science Foundation of Peking University Cancer Hospital#5 under Q.Z.[number 17-01].
Cachexia,which affects 50–80%of cancer patients,is a debilitating syndrome that leads to 20%of cancer-related deaths.A key feature of cachexia is adipose tissue atrophy,but how it contributes to the development of ca...
关键词：CANCER ELEVATED white 
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