DANSHENSU

作品数：18被引量：126H指数：7
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相关领域：医药卫生更多>>
相关作者：杨亚军冀国荣曹冬黄喜茹刘伟娜更多>>
相关机构：中国药科大学河北医科大学徐州医科大学中国中医研究院更多>>
相关期刊：《International Journal of Ophthalmology(English edition)》《Chinese Medical Journal》《Medical Bulletin of Shanghai Jiaotong University》《Chemical Research in Chinese Universities》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划河北省中医药管理局资助课题河北省卫生厅资助项目更多>>
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Danshensu alleviates pseudo-typed SARS-CoV-2 induced mouse acute lung inflammation被引量：2
《Acta Pharmacologica Sinica》2022年第4期771-780,共10页Wei Wang Sha-sha Li Xin-feng Xu Chan Yang Xiao-ge Niu Shu-xian Yin Xiao-yan Pan Wei Xu Guo-dong Hu Chan Wang Shu-wen Liu 
These authors gratefully acknowledge financial support from the Major Scientific and Technological Projects of Guangdong Province(2019B020202002);Chinese Academy of Traditional Chinese Medicine(ZZ13-035-02,2019XZZX-LG04)to SWL;Guangzhou Science and Technology Program(202008040001,201803040006 to WX and 2020B111110001 to SWL);National Natural Science Foundation of China(82070083 to GDH).
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)can induce acute inflammatory response like acute lung inflammation(ALI)or acute respiratory distress syndrome,leading to severe progression and mortality.The...
关键词：DANSHENSU SARS-CoV-2 spike protein acute lung inflammation inflammatory cytokines 
Sodium Danshensu promotes the healing of stage 2 pressure injury wounds in ischemia/reperfusion injury rat models:possible regulation of apoptosis and inflammatory response被引量：8
《Journal of Traditional Chinese Medicine》2021年第4期571-580,共10页ZHANG Qiongzhi FU Tingting DAI Jianing ZHOU Zhinan SHEN Cuizhen 
Supported by the Health Commission of Zhejiang Province(Exploring the Mechanism of Danshensu Anti-apoptosis Effect in Rat Models of Stage 2 Pressure Injury Based on PI3K/AKT Pathway,No.2019KY470)。
OBJECTIVE:To investigate the protective effect and possible mechanism of sodium Danshensu(SDSS)against pressure injury caused by ischemia/reperfusion(I/R)injury.METHODS:Sprague-Dawley rats were randomly divided into f...
关键词：DANSHENSU APOPTOSIS anti-inflammatory agents reperfusion injury pressure ulcer wounds and injuries 
Danshensu Ameliorates Cardiac Ischaemia Reperfusion Injury through Activating Sirt1/Fox01/Rab7 Signal Pathway被引量：16
《Chinese Journal of Integrative Medicine》2020年第4期283-291,共9页SUN Da-wei GAO Qing QI Xin 
Supported by Scie nee and Tech no logy Planning Projects of Scie nee and Tech no logy Commissi on of Tia njin(No.18ZXDBSY00080);National Natural Science Foundation of China(No.81503504);Key Medical and Health Projects of Health and Family Planning Commissi on of Tianjin(No.2015KG110)。
Objective:To explore the specific molecular mechanisms of Danshensu(DSS)in the treatment of ischemia reperfusion injury(IRI).Methods:IRI model was established with isolated rat hearts by performing global ischaemia fo...
关键词：Chinese medicine DANSHENSU ISCHEMIA REPERFUSION injury Sirt1/FoxO1/Rab7 signal pathway reactive oxygen species apoptosis 
Antioxidant effect of a novel synthetic hydrogen sulfide releasing Danshensu derivative and its clinical implications被引量：1
《中国药理学与毒理学杂志》2018年第4期273-274,共2页Jin-song BIAN 
Oxidative stress induces apoptosis of many cells and arrest of their differentiation.Both Danshensu(DSS) and hydrogen sulfide(H_2S) produce significant antioxidant effect in various systems.In this study,we synthesize...
关键词：细胞凋亡 丹神素 治疗方法 临床分析 
A lipophilic prodrug of Danshensu:preparation,characterization,and in vitro and in vivo evaluation被引量：6
《Chinese Journal of Natural Medicines》2017年第5期355-362,共8页GUO Xue-Jiao FAN Xue-Jiao QIAO Bin GE Zhi-Qiang 
supported by the National Natural Science Foundation of China(No.31371014)
Danshensu [3-(3, 4-dihydroxyphenyl) lactic acid, DSS], one of the significant cardioprotective components, is extracted from the root of Salvia miltiorrhiza. In the present study, an ester prodrug of Danshensu(DSS), p...
关键词：DANSHENSU PRODRUG Oral bioavailability Circulation time 
Cardioprotective and chemosensitizing effects of novel Danshensu derivatives
《中国药理学与毒理学杂志》2015年第S1期35-36,共2页LiangWANG Lu-chenSHAN Guo-zhenCUI JudyYuet-WaCHAN Jing-jingLI Qing-wenZHANG MaggiePui-ManHOI Yu-qiangWANG SimonMing-YuenLEE 
The project supported by grants from the Science and Technology Development Fund of Macao,China(014/2011/A1and 078/2011/A3);Research Committee,University of Macao〔MYRG138(Y1-Y4)-ICMS12-LMY〕
OBJECTIVE To investigate the cardioprotective effect of novel danshensu derivatives against doxorubicin(Dox)cardiotoxicity and their synergistic anti-tumor effect with Dox on breast cancer cells.METHODS Two new Danshe...
关键词：DANSHENSU DERIVATIVES DOXORUBICIN CARDIOTOXICITY m 
Novel derivative of Danshensu acts as anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57被引量：3
《中国药理学与毒理学杂志》2015年第S1期34-34,共1页Guo-zhenCUI Lu-chenSHAN LinGUO IvanKeungCHU Guo-huiLI QuanQUAN YunZHAO Chenong-mengCHONG ZaijunZHANG PeiYU Pui-manHOI Ye-weiSUN Yu-qiangWANG Simonming-yuenLEE 
The project supported by National Natural Science Foundation of China(81403139);Research Committee of the University of Macao(MYRG2015-00161-ICMS-QRCM)
OBJECTIVE To identify the specific targets of a novel derivative of Danshensu ADTM as the protein disulfide isomerase(PDI)family proteins including ERp57.To further investigate the underlying mechanism of ADTM to modu...
关键词：ANTI-PLATELET ERp57 DANSHENSU DERIVATIVE ADTM 
Simultaneous Determination of Five Hydrophilic and Lipophilic Components from roots of Salvia miltiorrhiza by HPLC被引量：10
《Chinese Herbal Medicines》2015年第1期75-79,共5页Li-lan Lu Shuang Hou Ting-ting Zheng Xing-li Zhang Jian-he Wei 
National Department Public Benefit Research Foundation(201107011)
Objective A reversed-phase HPLC method was established for the simultaneous determination of five hydrophilic and lipophilic components in the roots of Salvia miltiorrhiza. Methods Hydrophilic components including dan...
关键词：CRYPTOTANSHINONE DANSHENSU HPLC determination protocatechuic aldehyde Salviamiltiorrhiza salvianolic acid B tanshinone IIA 
Blends of hydrophobic and swelling agents in the swelling layer in the preparation of delayed-release pellets of a hydrophilic drug with low MW: Physicochemical characterizations and in-vivo evaluations被引量：2
《Asian Journal of Pharmaceutical Sciences》2014年第4期199-207,共9页Chang You Xuedan Liang Jiabei Sun Lin Sun Yitao Wang Tianyuan Fan Ying Zheng 
Financial support was provided by a research grant from the University of Macao(Research Grant RG085/09-10S/ZY/ICMS and UL016/09-Y4/CMS/WYT01/ICMS).
In this study,a hydrophobic material,ethylcellulose,which was used as its aqueous suspension Surelease^(®),was combined with a swelling agent as the swelling layer to prepare delayed-release pellets for Danshensu,whic...
关键词：DANSHENSU Delayed-release pellets Swelling agent Surelease^(®) Cross-linked sodium carboxymethyl cellulose(CCeNa) Fluidised bed 
Impact of Lycium Barbarum Polysaccharide and Danshensu on vascular endothelial growth factor in the process of retinal neovascularization of rabbit被引量：14
《International Journal of Ophthalmology(English edition)》2013年第1期59-61,共3页Xue-Min Tian Rui Wang Bai-Ke Zhang Chun-Lei Wang Hao Guo Shi-Jin Zhang 
National"Eleventh Five-year Plan"Science and Technology Support Project,China(No.2006BAI06A15-3)
AIM:To discuss the impact of Lycium Barbarum Polysaccharide (LBP) and Danshensu purified from Traditional Chinese Medicine (TCM) on vascular endothelial growth factor (VEGF) of rabbits with retinal neovascularization....
关键词：Lycium Barbarum Polysaccharide DANSHENSU vascular endothelial growth factor retinal neovascularization RABBIT 
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