supported by the National Natural Science Foundation of China(31930003 and 41976087);the National Key R&D Program of China(2018YFA0901300).
Cytochrome c maturation(CCM),a posttranslational modification involving covalent attachment of heme to polypeptides(apocyt c),is essential for the activity and cellular function of cytochromes c.Here,we identify and s...
The resolution adopted at the Third Plenary Session of the 20th CPC Central Committee set the objective of advancing whole-process people’s democracy, including promoting socialist rule of law with Chinese characteri...
The Resolution of the Central Committee of the Communist Party of China on Further Deepening Reform Comprehensively to Advance Chinese Modernization(hereinafter referred to as the“Resolution”)was reviewed and adopte...
National Natural Science Foundation(Grant Nos.82271598,81871109,82071587,31930058,32330023 and 32170757);National Key Research and Development Program of China(2018YFA0107003);Guang Dong Basic and Applied Basic Research Foundation(2020A1515010462).
Telomeres are specialized structures at the ends of linear chromosomes that protect genome stability.The telomeric repeat-containing RNA(TERRA)that is transcribed from subtelomeric regions can invade into double-stran...
supported by the National Key Research and Development Program of China(2022YFA0103200);the National Natural Science Foundation of China(82325003,82230007,82200188,82270956 and 82171568);the National Defense Biotechnology Outstanding Young Talents Fund(01-SWKJYCJJ24);Shaanxi Province Innovation Capability Support Program Scientific and Technological Innovation Team(2023-CX-TD-69).
Stem cells remain in a quiescent state for long-term maintenance and preservation of potency;this process requires fine-tuning regulatory mechanisms.In this study,we identified the epigenetic landscape along the devel...
This research was supported by Tsinghua University Initiative Scientific Research Program (to M.P.) and funds from Tsinghua-Peking Center for Life Sciences and Institute forImmunology at Tsinghua University (to M.P.).
The symbiotic relationship between the host and microbiota is widely acknowledged as mutually beneficial.However,due to significant differences in metabolic substrates and products between prokaryotic bacteria and mam...
a phased project of the “Research on the Principles of Argumentation of Ratio Legis (Reasons) in Local Legislation” (Project Approval Number 2023EFX002);a Youth Project of Shanghai Philosophy and Social Science Planning in 2023。
The participation of women in legislation is an important aspect and means of safeguarding women’s rights.Feminist theory,based on criticism of both the“citizenship identity theory as rights”and the“citizenship id...
supported by the 2021 National Social Sciencetitled“Research on the Legal Risks and Prevention of China’s Social Media Platforms Operating in the United States”(21BXW040)
The Metaverse is the digitization of the real world,supported by big data,AI,5G,cloud computing,blockchain,encryption algorithm,perception technology,digital twin,virtual engine,and other technologies that interact wi...
We thank Dr Masaru Okabe at Osaka University Japan for providing the B6D2-Tg(CAG/Su9-DsRed2,Acr3-EGFP)RBGS002Osb mice(mito-red);the National Institute for Basic Biology Japan for providing the B6.Cg-Tg(CAG-GFP/LC3)53Nmz/NmzRbrc mice.;the National Key R&D Program of China 2018YFA0108402;the Strategic Priority Research Program of the Chinese Academy of Sciences XDA16030302;the Strategic Collaborative Research Program of the Ferring Institute of Reproductive Medicine Grant No.33,and the National Natural Science Foundation of China Program(31720103907,31570995,31621004),to T.Z.and(31400831)to J.C.The raw data FASTQ files for the RNA sequencing data are deposited in NCBI GEO,GEO:GSE140712(Fig.1D,1E and S4)and ScienceDB,China National Standard GB/T 7714-2015(Fig.S8A,S8F and S8G);The metabolomic data files are deposited in ScienceDB,China National Standard GB/T 7714-2015.
Dear Editor,Embryonic stem cells(ESCs)have been assumed to possess immature mitochondria and to favor anaerobic glycolysis over oxidative phosphorylation(OXPHOS)for energy production.This proposition is largely based ...
supported by the National Key Research and Development Program of China (2018YFD0900202);the National Natural Science Foundation of China (31972778, 31861123001, 31630082, 31872556);the Chongqing Science and Technology Commission (cstc2018jscx-mszd0380, cstc2018jcyj AX0283);Yunnan Science and Technology project (2018IB019)。
The role of glucocorticoids in oogenesis remains to be elucidated. cyp11c1 encodes the key enzyme involved in the synthesis of cortisol, the major glucocorticoid in teleosts. In our previous study, we mutated cyp11c1 ...