PRODRUGS

作品数：67被引量：100H指数：5
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相关领域：医药卫生化学工程更多>>
相关作者：张礼和谢璐佳郭颖卢俊峰徐靖源更多>>
相关机构：中国医学科学院北京协和医学院北京大学香港城市大学天津医科大学更多>>
相关期刊：《Nano-Micro Letters》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金天津市自然科学基金中国博士后科学基金教育部留学回国人员科研启动基金更多>>
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Paclitaxel-lipid prodrug liposomes for improved drug delivery and breast carcinoma therapy
《Chinese Chemical Letters》2024年第2期335-340,共6页Xin Wu Xinmei Chen Xinyu Wang Haisheng He Jianming Chen Wei Wu 
supported by National Natural Science Foundation of China(Nos.82273867,82030107);Shanghai Science and Technology Project of Little Giant(No.1902HX76600);Shanghai Qingpu District Industry-University-Research Cooperative Development Funding Project(No.2022-7);High-level Talents of Fujian University of Chinese Medicine(No.X2019006-Talents).
Paclitaxel(PTX)is widely applied for the treatment of unresectable and metastasis breast carcinoma as well as other cancers,whereas its efficacy is always impeded by poor solubility.Liposomes are one kind of the most ...
关键词：PACLITAXEL LIPIDS PRODRUGS Liposomes Drug release CHEMOTHERAPY 
Supramolecular nanoparticles constructed by orthogonal assembly of pillar[5]arene-cyclodextrin dimacrocycle for chemo-photodynamic combination therapy被引量：1
《Chinese Chemical Letters》2023年第11期153-158,共6页Yongfei Yin Penghao Sun Hongqiang Dong Yi Chen Shigui Chen Lu Wang 
supported by National Natural Science Foundation of China(Nos.21702153 and 21801194);Wuhan Science and Technology Bureau(No.whkxjsj009);the support of the Core Facility of Wuhan University and the Large-scale Instrument and Equipment Sharing Foundation of Wuhan University.
Chemotherapy combined with photodynamic therapy has emerged as a promising strategy for cancer treatment.However,simultaneously delivering chemotherapeutic drugs and photosensitizers and precisely adjusting the ratio ...
关键词：Supramolecular nanoparticles Host-guest systems Photodynamic therapy Drug delivery PRODRUGS 
Acid-sensitive PEGylated cabazitaxel prodrugs for antitumor therapy
《Chinese Chemical Letters》2021年第5期1751-1754,共4页Tao Liu Hui Zou Jingqing Mu Na Yu Yang Xu Guohua Liu Xingjie Liang Shutao Guo 
This work was supported by the National Natural Science Foundation of China(No.51773098);the Natural Science Foundation of Tianjin of China(No.18JCYBJC28300);the Fundamental Research Funds for Central Universities(China).
Although the antitumor drug cabazitaxel shows great therapeutic potential,its high toxicity and poor water solubility limit its utility.However,the use of stimuli-responsive prodrugs is a promising strategy for overco...
关键词：PRODRUGS Acid-sensitive Antitumor therapy CABAZITAXEL PEGYLATION 
Facile preparation of pH-responsive PEGylated prodrugs for activated intracellular drug delivery被引量：3
《Chinese Chemical Letters》2019年第12期2027-2031,共5页Yue Song Dian Li Jinlin He Mingzu Zhang Peihong Ni 
the financial supports from the National Natural Science Foundation of China(No.21374066);the Major Program of the Natural Science Project of Jiangsu Higher Education Institutions(No.15KJA150007);Natural Science Foundation of Jiangsu Province(No.BK20171212);the Project Funded by the Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions;Soochow-Waterloo University Joint Project for Nanotechnology from Suzhou Industrial Park
PEGylated prodrug,covalent attaching polyethylene glycol(PEG) polymer chains to therapeutic drugs,is one of the most promising techniques to improve the water-solubility,stability,and therapeutic effect of drugs.In th...
关键词：Polyethylene glycol DOXORUBICIN PRODRUG Schiff-base reaction pH-Responsiveness 
Self-assembled small molecular weight hydrogels of prodrugs被引量：1
《Chinese Chemical Letters》2017年第9期1835-1840,共6页Yanfang Zhou Xingyi Li 
financially supported by grants from the National Natural Science Foundation of China(No.31671022);the Key Program for International S&T Cooperation Projects of China(No.2015DFA50310);the National Science and Technology Major Project(No.2014ZX09303301)
Molecular self-assembly is very ordinary phenomenon in the biological process such as protein folding,DNA encoding and etc.Inspired by this inherent biological process,nanostructure such as nanofibers,nanosphere,and s...
关键词：Small molecular weight hydrogel Self-assembly Prodrug Drug delivery 
Synthesis,pharmacokinetics and in vivo antifungal activity of the novel water-soluble prodrugs of itraconazole analogue YL-24被引量：2
《Chinese Chemical Letters》2013年第4期321-324,共4页Yu Liu Xu-Feng Cao Xin Liu Yong-Bing Cao Wen-Jing Chu Yu-She Yang 
National Science and Technology Major Project for the support to this research;supported by Key New Drug Creation and Manufacturing Program, China(No.2009ZX09301-001)
To improve the aqueous solubility of an itraconazole analogue, compound 1 （YL-24）, a series of novel prodrugs were synthesized. Among these prodrugs, the phosphate disodium salt compound 7 exhibited excellent aqueou...
关键词：SynthesisAntifungalWater-soluble prodrugsltraconazole analogue 
Design,synthesis and preliminary biological evaluation of brain targeting L-ascorbic acid prodrugs of ibuprofen被引量：3
《Chinese Chemical Letters》2013年第2期117-119,共3页Xue-Ying Wu Xiao-Cen Li Jie Mi Jing You Li Hai 
supported by the Ph.D.Programs Foundation of Ministry of Education of China(No.20110181130011);the National Natural Science Foundation of China(No.81072532)
Received 4 November 2012 Received in revised form 17 December 2012 Accepted 31 December 2012 Available online 4 February 2013
关键词：Vitamin CBrain targetProdrugGLUT1 transporterSVCT2 transporterIbuprofen 
Design,synthesis and in vitro evaluation of mono(2,2,2-trifluoroethyl)esters,mono L-amino acid ester prodrugs of acyclic nucleoside phosphonates as anti-HBV agents被引量：2
《Chinese Chemical Letters》2011年第12期1387-1390,共4页Xiao Zhong Fu Yu Ou Jan Xin Yu She Yang 
supported by the grants from the National Natural Science Foundation of China(No.20962004);the Provincial Social Development Foundation of Guizhou,China(No.QKHSYZ[2009]3081);Provincial Special Assistant Foundation for High-level Talents of Guizhou,China(No.TZJF-2009-36);Science and Technology Foundation of Guizhou Province,China(No.QKHJZ[2008]2140)
A series of novel mono（2,2,2-trifluoroethyl） esters,mono L-amino acid ester prodrugs of acyclic nucleoside phosphonates was synthesized and their in vitro anti-HBVactivity was evaluated in HepG 2 2.2.15 cells.Compou...
关键词：Acyclic nucleoside phosphonates L-Amino acid PRODRUG 
Synthesis and biological evaluation of lipid-soluble prodrugs of anethole dithiolthione被引量：3
《Chinese Chemical Letters》2010年第12期1427-1429,共3页Mei Guan Wei Fan Shan Qian Rui Qi Xiao Yong Wu 
16 ADT carboxylate esters were prepared by means of esterification and these compounds were expected to increase the bioavailability of 4-hydroxyanehole trithione.In vivo studies showed that ADT concentration of 3a in...
关键词：SYNTHESIS Anethole dithiolthione Liposoluble BIOAVAILABILITY PRODRUG 
Design, synthesis and in vitro evaluation of L-amino acid esters prodrugs of acyclic nucleoside phosphonates as anti-HBV agent被引量：1
《Chinese Chemical Letters》2007年第7期817-819,共3页Xiao Zhong Fu Sai Hong Jiang Jian Xin Yu She Yang RU Yun Ji 
A series of novel L-amino acid esters prodrugs of acyclic nucleoside phosphonates was synthesized and their anti-HBV activity was evaluated in HepG2 2.2.15 cells. Compound 1d exhibited more potent anti-HBV activity an...
关键词：Acyclic nucleoside phosphonates L-Amino acid PRODRUG Anti-HBV activity 
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