PYRIDONE

作品数：20被引量：30H指数：3
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Prediction of the Photofading of Selected Derivatives of 5-(4-X-Phenylazo)-3-Cyano-1-(H or Ethyl)-6-Hydroxy-4-Methyl-2-Pyridone: Theoretical Studies, Comparison of AM1 and PM3 Methods
《Computational Chemistry》2024年第2期25-56,共32页Krzysztof Wojciechowski Lucjan Szuster 
We analysed the photooxidation reaction in the electro-(1O2) and nucleophilic (O2•−) reaction of 2-pyridone azo derivatives. First, we calculated the energy (enthalpies) of tautomers formation, which is a measure of d...
关键词：Photochemical Degradation AM1 and PM3 Methods Boundary Orbitals Electron Densities Electrophilic and Nucleophilic Reaction HOMO and LUMO Orbitals 
Structure-based design of novel heterocyclesubstituted ATDP analogs as non-nucleoside reverse transcriptase inhibitors with improved selectivity and solubility
《Acta Pharmaceutica Sinica B》2023年第12期4906-4917,共12页Li-Min Zhao Christophe Pannecouque Erik De Clerc Shuai Wang Fen-Er Chen 
financially supported by National Natural Science Foundation of China(No.22077018).
Following on our recently developed biphenyl-ATDP non-nucleoside reverse transcriptase inhibitor ZLM-66(SI=2019.80,S=1.9μg/mL),a series of novel heterocycle-substituted ATDP derivatives with significantly improved se...
关键词：HIV-1 RT NNRTIS ATDP PYRIDONE 
Structure-directed expansion of biphenyl-pyridone derivatives as potent non-nucleoside reverse transcriptase inhibitors with significantly improved potency and safety被引量：1
《Chinese Chemical Letters》2023年第12期126-131,共6页Li-Min Zhao Christophe Pannecouque Erik De Clercq Shuai Wang Fen-Er Chen 
funded by the National Natural Science Foundation of China(No.22077018).
Following our previous work on human immunodeficiency virus-1(HIV-1)non-nucleoside reverse transcriptase inhibitors(NNRTIs),a series of novel biphenyl-pyridone derivatives were synthesized and evaluated for their anti...
关键词：HIV-1 NNRTI Doravirine Biphenyl-pyridone SAFETY 
The water-soluble bicyclic 2-pyridone-based fluorescent probe for fast and selective detection of hypochlorite
《Chinese Chemical Letters》2023年第6期432-436,共5页Qian Zhou Shanqiang Wang Xiaoyun Ran Linzhi Shen Xiaolin Luo Gui Wang Hui Yang Zhouyu Wang Xiaoqi Yu 
financially supported by the National Natural Science Foundation of China(No.21877082);the International Science and Technology Innovation Cooperation Project of Sichuan Province(No.2021YFH0132);the Sichuan Science and Technology Program(No.2021YFG0291);the Undergraduate Scientific and Technological Innovation Project(Nos.2021127,2021130),Xihua University。
As a strong oxidizer,hypochlorite(Cl O^(-))are widely employed as bleaching agents and disinfectants.Determination of ClO^(-)is required to ensure bactericidal effects and avoid hazards caused by excessive residual ch...
关键词：Fluorescent probe HYPOCHLORITE Bicyclic 2-pyridone Tap water BIOIMAGING 
A BODIPY-modified polymeric micelle for sustaining enhanced photodynamic therapy被引量：1
《Chinese Chemical Letters》2022年第6期3277-3280,共4页Yun-Chang Zhang Lan She Zi-Yue Xu Ze-Kun Wang Zhiqiang Ma Feng Yang Zhan-Ting Li 
Shanghai Sailing Program (No. 20YF1458000)。
Photodynamic therapy(PDT) has been gaining popularity in both scientific research and clinic applications due to its non-invasiveness and spatiotemporal targeting properties. Nevertheless, the local hypoxic microenvir...
关键词：Photodynamic therapy Polymeric micelle BODIPY 2-Pyridone TUMOR 
PhlCl_(2)/NH_(4)SCN-Mediated Oxidative Regioselective Thiocyanation of Pyridin-2(1H)-ones
《Chinese Journal of Chemistry》2021年第9期2536-2546,共11页Shanqing Tao Jiaxi Xiao Yadong Li Fengxia Sun Yunfei Du 
Y.Du acknowledges the National Natural Science Foundation of China(No.22071175)for financial support.
The reaction of pyridin-2(1H)·ones with PhlCl_(2) and NH_(4)SCN enables an efficient regioselective thiocyanation,leading to the synthesis of the biologically interesting C5 thiocyanated 2-pyridones in good to high y...
关键词：PYRIDONE PhlCl_(2) Thiocyanogen chloride REGIOSELECTIVE Electrophilic thiocyanation 
A Singlet Oxygen Reservoir Based on Poly-Pyridone and Porphyrin Nanoscale Metal-Organic Framework for Cancer Therapy被引量：1
《CCS Chemistry》2021年第5期1187-1202,共16页Bo-Ru Xie Chu-Xin Li Yun Yu Jin-Yue Zeng Ming-Kang Zhang Xiao-Shuang Wang Xuan Zeng Xian-Zheng Zhang 
This study was supported by the National Natural Science Foundation of China(nos.51833007,51873162,21721005,and 51690152).
Here,a methacrylate-modified pyridone derivative(mPYR)was loaded into a porphyrin nanoscale metal-organic framework(porphyrin-nMOF).Then,the loaded mPYR was further polymerized to obtain poly-pyridone(poly-mPYR)to for...
关键词：cancer ENDOPEROXIDES pyridone derivative metal-organic framework PHOTODYNAMICTHERAPY 
Effect of substituents in hydroxyl radical-mediated degradation of azo pyridone dyes: Theoretical approaches on the reaction mechanism被引量：1
《Journal of Environmental Sciences》2020年第12期14-21,共8页J.Dostanic M.Hus D.Loncarevic 
supported by the Ministry of Education,Science and Technological Development of the Republic of Serbia and the Slove-nian Research Agency (research core funding No. P2-0152)。
Understanding the degradation behavior of azo dyes in photocatalytic wastewater treatment is of fundamental and practical importance for their application in textile-processing and other coloration industries. In this...
关键词：Quantum chemical calculation Density functional theory Azo dye Reaction mechanism Photocatalytic degradation Hydroxyl radical Hammett equation Substituent effect 
Characterization of the positive SARP family regulator PieR for improving piericidin A1 production in Streptomyces piomogeues var.Hangzhouwanensis被引量：5
《Synthetic and Systems Biotechnology》2019年第1期16-24,共9页Yan Li Lingxin Kong Jufang Shen Qing Wang Qian Liu Weinan Yang Zixin Deng Delin You 
the National Natural Science Foundation of China(31630002,31700029,31770038,31470183,21661140002 and 31170085);the Ministry of Science and Technology;Shanghai Pujiang Program from the Shanghai Municipal Council of Science and Technology(12PJD021);China Postdoctoral Science Foundation(2017M620151).
Piericidin A1,a member ofɑ-pyridone antibiotic,exhibits various biological activities such as antimicrobial,antifungal,and antitumor properties and possesses potent respiration-inhibitory activity against insects due...
关键词：ɑ-pyridone antibiotic Transcriptional regulation SARP family regulator Secondary metabolic STREPTOMYCES 
Effect of pyridone agent on blood-retinal barrier in diabetic mice被引量：2
《International Journal of Ophthalmology(English edition)》2017年第6期890-895,共6页Si-Qi Xiong Hai-Bo Jiang Hui-Zhuo Xu Xiao-Bo Xia 
Supported by National Natural Science Foundation of China(No.81000388);Health and Family Planning Commission of Hunan Province(No.132015-016);Natural Science Foundation of Hunan Province(No.12JJ3120)
AIM： To evaluate the therapeutic effect of fluorofenidone on disrupted blood-retinal barrier in the diabetic mice and uncover its underlying mechanism. METHODS： db/db mice were randomly chosen for treatment with da...
关键词：pyridone agent diabetic retinopathy blood-retinal barrier 
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