KILLER

作品数：349被引量：784H指数：13
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  • 期刊=Signal Transduction and Targeted Therapyx
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Comprehensive snapshots of natural killer cells functions,signaling,molecular mechanisms and clinical utilization
《Signal Transduction and Targeted Therapy》2024年第12期5431-5469,共39页Sumei Chen Haitao Zhu Youssef Jounaidi 
Supported by Innovation Grants DAPCM(232129,245130);President and Fellows of Harvard College Myles shore fellowship(241317)to Y.J.S.C;supported by Scientific Research Funds of Zhejiang Province Health Department 2024ky205;Hangzhou Agricultural and Social Development Key Scientific Research Project 202004A19;supported by Guizhou Province Science Technology Project(2024)051.
Natural killer(NK)cells,initially identified for their rapid virus-infected and leukemia cell killing and tumor destruction,are pivotal in immunity.They exhibit multifaceted roles in cancer,viral infections,autoimmuni...
关键词：KILLER HEALING WOUND 
Sintilimab(anti-PD-1 antibody)plus chidamide(histone deacetylase inhibitor)in relapsed or refractory extranodal natural killer T-cell lymphoma(SCENT):a phase Ⅰb/Ⅱ study被引量：3
《Signal Transduction and Targeted Therapy》2024年第6期2765-2773,共9页Yan Gao Haixia He Xueping Li Liling Zhang Wei Xu Ru Feng Wenyu Li Yin Xiao Xinxiu Liu Yu Chen Xiaoxiao Wang Bing Bai Huijing Wu Qingqing Cai Zhiming Li Jibin Li Suxia Lin Yanxia He Liqin Ping Cheng Huang Jiaying Mao Xiujin Chen Baitian Zhao Huiqiang Huang 
supported by the National Natural Science Foundation of China(grant numbers 82170188 and 81970176);Guangdong Basic and Applied Basic Research Foundation(grant number 2021A1515110012).
Anti-PD-1 antibodies are a favorable treatment for relapsed or refractory extranodal natural killer T cell lymphoma(RR-ENKTL),however,the complete response(CR)rate and the duration of response(DOR)need to be improved....
关键词：KILLER LYMPHOMA doses 
Anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma被引量：2
《Signal Transduction and Targeted Therapy》2024年第4期1665-1674,共10页Jie Xiong Shu Cheng Xiao Gao Shan-He Yu Yu-Ting Dai Xin-Yun Huang Hui-Juan Zhong Chao-Fu Wang Hong-Mei Yi Hao Zhang Wei-Guo Cao Rong Li Wei Tang Yan Zhao Peng-Peng Xu Li Wang Wei-Li Zhao 
supported,in part,by research funding from the National Natural Science Foundation of China (82130004 and 82270194);National key research and development program (2022YFC2502600);Chang Jiang Scholars Program,Shanghai Rising-Star Program (23QA1406100);Shanghai Municipal Commission of Science and Technology Project (23141903100);Shanghai Municipal Education Commission Gaofeng Clinical Medicine Grant Support (20152206,20152208,and 20161303);Clinical Research Plan of Shanghai Hospital Development Center (SHDC 2020CR1032B);Multicenter Clinical Research Project by Shanghai Jiao Tong University School of Medicine (DLY201601)。
Natural killer T cell lymphoma(NKTCL)is highly aggressive,with advanced stage patients poorly responding to intensive chemotherapy.To explore effective and safe treatment for newly diagnosed advanced stage NKTCL,we co...
关键词：KILLER METABOLISM LYMPHOMA 
Navigating Epstein–Barr virus autoimmunity:role of NK cells and T cells in multiple sclerosis被引量：1
《Signal Transduction and Targeted Therapy》2024年第3期833-835,共3页Chu Xie Cong Sun Mu-Sheng Zeng 
supported by grants from the National Key Research and Development Program of China(2022YFC3400900);Postdoctoral Fellowship Program of CPSF(GZB20230886);Chinese Postdoctoral Science Foundation(2023M743998);Natural Science Foundation of China(82030046);the Program for Guangdong Introducing Innovative and Entrepreneurial Teams(2019BT02Y198);Guangdong Science and Technology Department(2020B1212030004).
In a recent study published in Cell,Vietzen and colleagues discovered the novel role of natural killer(NK)cells and EBVspecific CD8+T cell response in controlling EBV-inducing autoimmune response and collectively defi...
关键词：EPSTEIN SCLEROSIS KILLER 
Calreticulin surface presentation: a signal for natural killer cells to attack
《Signal Transduction and Targeted Therapy》2023年第9期3883-3884,共2页Jasmine P.Castellanos Joseph C.Genereux 
This work was supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number R01GM134125.
In a recent article published in Nature,Sen Santara et al.report a general mechanism that allows endoplasmic reticulum(ER)stress,a common response to many cellular dysfunctions,to signal to natural killer(NK)cells to ...
关键词：KILLER SURFACE 
Natural killer cell homing and trafficking in tissues and tumors:from biology to application被引量：9
《Signal Transduction and Targeted Therapy》2022年第7期2448-2468,共21页Guang he Ran Yu qing Lin Lei Tian Tao Zhang Dong mei Yan Jian hua Yu You cai Deng 
supported by National Natural Science Foundation of China(Nos.81922068 and 81874313)Y.D.;This study was also supported by funding from the National Key Research and Development Project(Nos.2020YFA0113500 and 2019YFA0111200) Y.D.;This study was also supported by National undergraduate training program for innovation and entrepreneurship(No.2020XBK28)to Y.D.
Natural killer(NK)cells,a subgroup of innate lymphoid cells,act as the first line of defense against cancer.Although some evidence shows that NK cells can develop in secondary lymphoid tissues,NK cells develop mainly ...
关键词：KILLER ORGANS TRANSFERRED 
Natural killer cell-derived exosomal miR-1249-3p attenuates insulin resistance and inflammation in mouse models of type 2 diabetes被引量：5
《Signal Transduction and Targeted Therapy》2021年第12期3783-3795,共13页Ying Wang Mengwei Li Lin Chen Huan Bian Xiangying Chen Huilin Zheng Peiwei Yang Quan Chen Hanmei Xu 
This work was supported by grants from the Project Program of State Key Laboratory of Natural Medicines(SKLNMZZCX201821,SKLNMZZ202028);the National Science and Technology Major Projects of New Drugs(2019ZX09301124,2019ZX09201001,and 2019ZX09301-110)in China;This work was also supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);China Postdoctoral Science Foundation(2017M621884,2020M681787);“Double First-Class”University project of China Pharmaceutical University(CPU2018GY13,CPU2018PZH03).
Natural killer(NK)cells have been suggested to be associated with type 2 diabetes by regulating systemic inflammation.However,the mechanism by which NK cells regulate insulin sensitivity remains unknown.This study sho...
关键词：INFLAMMATION miR124 KILLER 
The anti-inflammatory astrocyte revealed:the role of the microbiome in shaping brain defences
《Signal Transduction and Targeted Therapy》2021年第5期1404-1405,共2页Alexei Verkhratsky Peter Illes Yong Tang Alexey Semyanov 
This work was supported by grants of the National Key R&D Programme of China(2019YFC1709101);the Project First-Class Disciplines Development of Chengdu University of Traditional Chinese Medicine(CZYHW1901)awarded in order to build up the“International Collaborative Centre on Big Science Plan for Purinergic Signalling”,and the Science and Technology Programme of Sichuan Province,China(2019YFH0108);The stay and work of PI in Chengdu was supported by a grant from the State Administration of Foreign Experts Affairs(G20190236012);A.S.and Y.T.are supported by RFBR grant 21-54-53018 for the NSFC-RFBR project.
The paper,published recently in Nature by the group of Francisco Quintana,1 describes the anti-inflammatory astrocytes,activity of which is tuned by the microbiotome and meningeal natural killer(NK)cells.Astrocytes ar...
关键词：inflammatory STASIS KILLER 
Combination of anti-PD-1 antibody with P-GEMOX as apotentially effective immunochemotherapy for advancednatural killer/T cell lymphoma被引量：1
《Signal Transduction and Targeted Therapy》2021年第1期184-192,共9页Jun Cai Panpan Liu Huiqiang Huang Yajun Li Shuyun Ma Hui Zhou Xiaopeng Tian Yuchen Zhang Yan Gao Yi Xia Xuanye Zhang Hang Yang Lirong Li Qingqing Cai 
This work was supported by the National Natural Science Foundation of China(81672686);Special Support Program of Sun Yat-sen University Cancer Center(PT19020401);Science and Technology Planning Project of Guangzhou,China(202002030205);Clinical Oncology Foundation of Chinese Society of Clinical Oncology(Y-XD2019-124).
Advanced natural killer/T cell lymphoma(NKTL)has demonstrated poor prognosis with currently available therapies.Here,we report the efficacy of anti-programmed death 1(PD-1)antibody with the P-GEMOX(pegaspargase,gemcit...
关键词：alterations KILLER LYMPHOMA 
Randomized,multicenter,open-label trial of autologous cytokine-induced killer cell immunotherapy plus chemotherapy for squamous non-small-cell lung cancer:NCT01631357被引量：5
《Signal Transduction and Targeted Therapy》2020年第1期418-420,共3页Liang Liu Quanli Gao Jingting Jiang Junping Zhang Xin Song Jiuwei Cui Yunbin Ye Zhiyu Wang Xinwei Zhang Xiubao Ren 
supported by the National Key Technologies R&D Program of China grant Awards No.2015BAI12B12(to X.R.)and 2018YFC1313400(to J.X.);the National Natural Science Foundation of China grants Awards No.81572913 and 81872487(to L.L.).
Dear Editor,Cytokine-induced killer(CIK)cells have been recognized as a new type of anti-tumor effector cells.CIK cells are a mixture of T lymphocytes.Among them,CD3+/CD56+T cells,which are rare in uncultured peripher...
关键词：KILLER CHEMOTHERAPY SQUAMOUS 
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