ANABOLIC

作品数：36被引量：84H指数：5
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相关领域：医药卫生更多>>
相关作者：单娟路兴中张戈更多>>
相关机构：香港浸会大学西北农业大学同济大学附属同济医院更多>>
相关期刊：《Bioactive Materials》《Sports Medicine and Health Science》《Synthetic and Systems Biotechnology》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金瑞士科学基金更多>>
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Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects
《Bone Research》2024年第3期734-744,共11页Zhenqiang Yao Akram Ayoub Venkatesan Srinivasan Jun Wu Churou Tang Rong Duan Aleksa Milosavljevic Lianping Xing Frank H.Ebetino Alison J.Frontier Brendan F.Boyce 
funded by National Institutes of Health,National Institute on Aging,grant numbers,R01AG076731,R01AG049994;National Institute for Arthritis and Musculoskeletal and Skin Diseases,R01AR043510,and P30 AR069655。
Osteoporosis remains incurable.The most widely used antiresorptive agents,bisphosphonates(BPs),also inhibit bone formation,while the anabolic agent,teriparatide,does not inhibit bone resorption,and thus they have limi...
关键词：res CONJUGATE phosphonate 
β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture被引量：2
《Bone Research》2024年第2期302-313,共12页Jie Huang Tong Wu Yi-Rong Jiang Xuan-Qi Zheng Huan Wang Hao Liu Hong Wang Hui-Jie Leng Dong-Wei Fan Wan-Qiong Yuan Chun-Li Song 
supported by the National Natural Science Foundation of China(Grant Nos.82330078,81874010);the National Key Research and Development Program(Grant Nos.2020YFC2009004,2021YFC2501700).
The autonomic nervous system plays a crucial role in regulating bone metabolism,with sympathetic activation stimulating bone resorption and inhibiting bone formation.We found that fractures lead to increased sympathet...
关键词：BLOCKER METABOLISM inhibited 
Effects of Neuromuscular Electrical Stimulation in Combination with Glutamine Administration on Skeletal Muscle Atrophy in Colon-26 Tumor-Bearing Mice
《Proceedings of Anticancer Research》2023年第6期21-32,共12页Daisuke Tatebayashi Koichi Himori Yuki Ashida Takashi Yamada 
The depressed protein synthetic response,a phenomenon termed anabolic resistance,has been shown to be involved in muscle wasting induced by cancer cachexia.Moreover,a positive relationship between the protein syntheti...
关键词：Cancer cachexia Anabolic resistance Muscle atrophy GLUTAMINE Neuromuscular electrical stimulation 
Enzymatic properties and inhibition tolerance analysis of key enzymes inβ-phenylethanol anabolic pathway of Saccharomyces cerevisiae HJ被引量：1
《Synthetic and Systems Biotechnology》2023年第4期772-783,共12页Qilin Yang Shuangping Liu Yuzong Zhao Xiao Han Rui Chang Jian Mao 
supported by the National Natural Science Foundation of China(32072205,22138004);Shaoxing Science and Technology Plan Project(2022B43001).
Huangjiu is known for its unique aroma,primarily attributed to its high concentration ofβ-phenylethanol(ranging from 40 to 130 mg/L).Phenylalanine aminotransferase Aro9p and phenylpyruvate decarboxylase Aro10p are ke...
关键词：Ehrlich pathway Phenylalanine aminotransferase and phenylpyruvate decarboxylase Saccharomyces cerevisiae Metabolic engineering Escherichia coli 
DMMIC derivatization-assisted liquid chromatography-mass spectrometry method for metabolite profiling of the glutathione anabolic pathway in esophageal cancer tissues and cells被引量：1
《Journal of Pharmaceutical Analysis》2023年第11期1365-1373,共9页Li Liu Yu-Han Lu Min-Dan Wang Qun-Fei Zhao Xiu-Ping Chen Hang Yin Chen-Guo Feng Fang Zhang 
We thank the Shanghai Municipal Committee of Science and Technology(Grant Nos.:20XD1423400,23ZR1460900 and 20DZ2201100);Shanghai Municipal Health Commission/Shanghai Municipal Administration of Traditional Chinese Medicine(Grant No.:ZY(2021e2023)-0501);Shanghai Science and Technology Development Fund from Central Leading Local Government(Grant No.:YDZX20223100001004);National Natural Science Foundation of China(Grant No.:21672249);Expenditure Budget Program of Shanghai University of Traditional Chinese Medicine(Grant Nos.:2020LK051,and 2021LK001).
In this work,a new pyrylium derivatization-assisted liquid chromatography-mass spectrometry(LC-MS)method was developed for metabolite profiling of the glutathione anabolic pathway(GAP)in cancer tissues and cells.The p...
关键词：Glutathione anabolic pathway Metabolite profiling DMMIC derivatization LC-MS Esophageal squamous cell carcinoma p-Hydroxycinnamaldehyde KYSE-150cell 
Anti-inflammatory and anabolic biphasic scaffold facilitates osteochondral tissue regeneration in osteoarthritic joints
《Journal of Materials Science & Technology》2023年第25期20-31,共12页Xiangbo Meng Ling Li Cuishan Huang Keda Shi Qingqiang Zeng Chunyi Wen Sibylle Grad Mauro Alini Ling Qin Xinluan Wang 
supported by the collaborative project from the National Key R&D Program of China and Innovation and Tech-nology Fund Mainland-Hong Kong Joint Funding Scheme(Nos.2021YFE0202300 and MHP/011/20);the Sino-Swiss collaborative project from the Ministry of Science and Technology and the Swiss National Science Foundation under the SSSTC program(Grant Nos.2015DFG32200 and 156362);Shenzhen Collaborative Innovation Plan-International Cooperation Project(Grant No.GJHZ20190821160803823);Development and Reform Commission of Shenzhen Municipality(2019)(No.561);Shenzhen Double Chain Project for Innovation and Development Industry supported by Bureau of Industry and Information Technology of Shenzhen(No.201908141541).
Osteochondral defects (OCD) are common but difficult to heal due to the low intrinsic repair capacity of cartilage and its complex hierarchical structure. In osteoarthritis (OA), OCD become more challenging to repair ...
关键词：Biphasic scaffold Osteochondral defect Osteoarthritis Kartogenin CINNAMALDEHYDE ANTI-INFLAMMATION 
Reversal of the diabetic bone signature with anabolic therapies in mice
《Bone Research》2023年第2期328-339,共12页Silvia Marino Nisreen Akel Shenyang Li Meloney Cregor Meghan Jones Betiana Perez Gaston Troncoso Jomeeka Meeks Scott Stewart Amy YSato Intawat Nookaew Teresita Bellido 
This research was supported by the Veterans Administration I01 BX002104 and IK6BX004596 to T.B.;R01-AR059357 to T.B.;UAMS College of Medicine Sturgis Endowment Grant to T.B.;ASH scholar award to S.M.;National Center for Advancing Translational Sciences of the National Institutes of Health KL2TR003108 and UL1TR003107 to A.Y.S.;National Institute of General Medical Sciences of the National Institutes of Health P20GM125503 to I.N.
The mechanisms underlying the bone disease induced by diabetes are complex and not fully understood;and antiresorptive agents,the current standard of care,do not restore the weakened bone architecture.Herein,we reveal...
关键词：SIGNATURE POROSITY corrected 
Osteocytes regulate bone anabolic response to mechanical loading in male mice via activation of integrinα5被引量：3
《Bone Research》2022年第4期757-769,共13页Dezhi Zhao Rui Hua Manuel A.Riquelme Hongyun Cheng Teja Guda Huiyun Xu Sumin Gu Jean X.Jiang 
supported by the National Institutes of Health(NIH)Grants:AR072020(to J.X.J.);Welch Foundation grant:AQ-1507(to J.X.J.).
Physical mechanical stimulation can maintain and even increase bone mass.Here,we report an important role of osteocytic integrinα5 in regulating the anabolic response of bone to mechanical loading using an Itga5 cond...
关键词：loading ACTIVATION TOGETHER 
Red Beetroot Juice and Stamina: An Experimental Study
《Journal of Biosciences and Medicines》2022年第9期18-29,共12页Galina Smirnova Peteris Tretjakovs Anna Fedotova Raimonds Simanis Svetlana Vasiļjeva Olegs Suhorukovs Dalija Seglina Inta Krasnova Vadims Bartkevics Dmitry Babarykin 
Introduction: Red beet juice is increasingly used in sports to enhance the endurance of athletes. To increase the specific efficiency of red beet juice, the method of its fractionation by ultrafiltration was used for ...
关键词：Red Beetroot ULTRAFILTRATION Running Trained Rats Muscle Strength ENDURANCE Anabolic Effect Glutamic Acid 
Effects of salinity and alkalinity on fatty acids, free amino acids and related substance anabolic metabolism of Nile tilapia被引量：1
《Aquaculture and Fisheries》2022年第4期389-395,共7页Yamei Cheng Jinliang Zhao Christian Larbi Ayisi Xiaoying Cao 
The authors are thankful to China Agriculture Research System(CARS-46).
A 56-day experiment was conducted to investigate the effects of ambient salinity and alkalinity on fatty acids,free amino acids and related anabolic metabolisms of Nile tilapia.The fatty acid and free amino acid conte...
关键词：Nile tilapia Nutritional value FLAVOR METABOLISM SALINITY ALKALINITY 
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