supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA16030400);the National Basic Research Program of China(Grant No.2014CB964800);the National Natural Science Foundation of China(Grant Nos.31621004,31422038);the National Key Research and Development Program(Grant No.2017YFA0103803);CAS Key Projects(Grant No.QYZDY-SSWSMC022,QYZDB-SSW-SMC002).
Diploidy is the typical genomic mode in all mammals.Haploid stem cells are artificial cell lines experimentally derived in vitro in the form of different types of stem cells,which combine the characteristics of haploi...
supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA01010201);the National Key Basic Research and Development Program of China(2015CB964500 and 2014CB964804);the National Natural Science Foundation of China(91219303,31430058,and 31401261)
Dear Editor,Haploid embryonic stem cells(ha ESCs)hold great potential for genetic screening and the analysis of recessive phenotypes.Several studies have recently reported the generation of mammalian ha ESCs through...
supported by the National Key Basic Research Program of China(2012CB966500,2013CB-967100);the National Natural Science Foundation of China(31201112)
The androgenetic embyronic stem (aES) cells are useful models in studying the effects of imprinted genes on pluripotency maintaining and embryo development. The expression patterns of imprinted genes are significantly...
supported by grants from the Ministry of Science and Technology of China(No.2009CB941101 to J.L.);the "Strategic Priority Research Program" of the Chinese Academy of Sciences(No.XDA01010403 to J.L.).
Identification of the function of all genes in the mammalian genome is critical in understanding basic mechanisms of biology.However,the diploidy of mammalian somatic cells has greatly hindered efforts to elucidate th...