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作品数：223被引量：331H指数：8
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相关领域：医药卫生更多>>
相关作者：毛江高毕思玮孔芳曾志李培欣更多>>
相关机构：中国科学院福建物质结构研究所曲阜师范大学中国药科大学香港科技大学更多>>
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相关基金：国家自然科学基金中国博士后科学基金广东省自然科学基金北京市自然科学基金更多>>
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Screening of Chinese giant salamander meat hydrolysates with DPP-Ⅳinhibitory activity and systematic elucidation of their hypoglycemic functions in mouse model
《Food Science and Human Wellness》2025年第4期1305-1317,共13页Shucheng Li Changge Guan Yi Wang Haihong Chen Wei Li Songjun Wang Chong Zhang Xinhui Xing 
funded by the Shenzhen Agricultural Development Special Fund(Fishery)Agricultural High-tech Project([2021]735);SAMR technical guarantee project(2023YJ22 and 2023YJ37)。
Type 2 diabetes(T2D)presents a significant health challenge,underscoring the need for functional foods and nutraceutical hypoglycemic bioactive peptides for its prevention.This study investigates the potential of prot...
关键词：Chinese giant salamander Hypoglycemic effects Bioactive peptides Dipeptidyl dipeptidaseⅣ Multi-omics analysis 
Hymoins A–C,three unusual polycyclic polyprenylated acylphloroglucinols with lipid-lowering activity from Hypericum monogynum
《Chinese Chemical Letters》2025年第3期411-414,共4页Chunmao Yuan Yanrong Zeng Lei Huang Yu Mou Jun Jin Ping Yi Yanmei Li Xiaojiang Hao 
financially supported by the National Natural Science Foundation of China(Nos.32270413,82060631,82160808,and 82360035);the Science and Technology Department of Guizhou Province(Nos.QKHJC 2020–1Z076,QKHJC-ZK[2023]YB156,QKHJC-ZK[2021]YB569,and QKHPTRC[2020]5008);Excellent Young Talents Plan of Guizhou Medical University(2023,No.106);the 13thbatch of outstanding young scientific and technological talents in Guizhou Province(No.QKHPTRC[2021]5633);Guizhou Science and Technology Innovation Talent Team(No.QKHPTRC–CXTD[2022]007);High-level Innovative Talents in Guizhou Province(Thousand Levels of Talent for Chunmao Yuan in 2018);the project of State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University(Nos.FAMP202102K and QJJ[2023]113)。
Hymoins A–C(1–3),three unusual polycyclic polyprenylated acylphloroglucinols(PPAPs)were isolated from the flowers of Hypericum monogynum.Hymoin A features the first intriguing 6/5/5/5/7 pentacyclic caged PPAP.Hymoin...
关键词：Hypericum monogynum Polycyclic polyprenylated ACYLPHLOROGLUCINOLS Structure elucidation Lipid-lowering activity Mechanistic study 
Research progress in methods of acquisition,structure elucidation,and quality control of Chinese herbal polysaccharides
《Chinese Journal of Natural Medicines》2025年第2期143-157,共15页Tingting Wang Baojie Zhu Jing Zhao Shaoping Li 
supported by the Science and Technology Development Fund,Macao SAR (Nos.0075/2022/A and028/2022/ITP);the Zhuhai Science and Technology Plan Project in the Social Development Field (No.2220004000117);the University of Macao (Nos.MYRG-GRG2023-00082-ICMS-UMDF/CPG2024-00011-ICMS)。
The therapeutic efficacy of traditional Chinese medicine has been widely acknowledged due to its extensive history of clinical effectiveness.However,the precise active components underlying each prescription remain in...
关键词：Chinese medicine POLYSACCHARIDE Extraction and purification Structural analysis Quality control 
Structurally Diverse Limonoids from Trichilia connaroides and Their Antitumor Activities
《Chinese Journal of Chemistry》2024年第24期3567-3580,共14页Ying Yan Dan Wang Fang-Jiao Zhou Yu-Han Zhao Xu-Jie Qin Yu Zhang Xiao Ding Xiao-Jiang Hao 
Financial support for this study was provided by National Natural Science Foundation of China(82360687);Guizhou Provincial Science and Technology Project(ZK[2022]393);Key Research and Development Project of Yunnan Province(202203AC100009,202003AD150012);Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform(2022YKZY001).
Twelve new limonoids(1—12),named trichilitins A—L,were isolated from the leaves and twigs of Trichilia connaroides,together with ten known compounds(13—22).The structures were elucidated by extensive spectroscopic ...
关键词：Natural products LIMONOIDS MELIACEAE Structure elucidation Trichilia connaroides Antitumor activities p53 and p21 Structure-activity relationships Cancer treatment 
Genome-wide analyses of mi RNAs in mycorrhizal plants in response to late blight and elucidation of the role of miR319c in tomato resistance
《Horticultural Plant Journal》2024年第6期1371-1382,共12页Xiaoxu Zhou Zhengjie Wang Chenglin Su Jun Cui Jun Meng Yushi Luan 
supported by the National Natural Science Foundation of China (Grant Nos.32230091,32072592)。
Tomato(Solanum lycopersicum), an economically important vegetable crop cultivated worldwide, often suffers massive financial losses due to Phytophthora infestans(P. infestans) spread and breakouts. Arbuscular mycorrhi...
关键词：TOMATO Arbuscular mycorrhiza fungi Phytophthora infestans miRNA 
Skeleton Rearranged and Oxygenated ent-Rosane Diterpenoids with Antiadipogenic Activity from Euphorbia milii
《Chinese Journal of Chemistry》2024年第24期3211-3218,共8页Qin-Qin Song Yue Guo Peng Sun Yao-Yue Fan Kai-Long Ji 
Financial support from the National Natural Science Foundation of China(No.82122062);the 145 Programs(XTBG-145)of Xishuangbanna Tropical Botanical Garden,Chinese Academy of Sciences(CAS);the Program of CAS Key Laboratory of Tropical Plant Resources and Sustainable Use(No.20228012802)is highly acknowledged.
Five unreported and oxygenated ent-rosane diterpenoids(ent-RDs),Euphomillanols A—E(1—5),were isolated from Euphorbia milii.Among them,compounds 1 and 2 are unprecedented 7/7/6-fused tricyclic 5,10-seco-ent-RDs and p...
关键词：ent-Rosane diterpenoids Euphorbia milii Structure elucidation Configuration determination Biosynthetic pathway hypothesis Oxidation Biological activity Antiadipogenic activity 
Network Pharmacology Based Elucidation of Molecular Mechanisms of Laoke Formula for Treatment of Advanced Non-Small Cell Lung Cancer
《Chinese Journal of Integrative Medicine》2024年第11期984-992,共9页FENG Yu-yu LIU Jin-feng XUE Yang LIU Dan WU Xiong-zhi 
Supported by National Natural Science Foundation of China(Nos.82174103 and 81473441)。
Objective: To explore the specific pharmacological molecular mechanisms of Laoke Formula(LK)on treating advanced non-small cell lung cancer(NSCLC) based on clinical application, network pharmacology and experimental v...
关键词：LaoKe Formula non-small cell lung cancer network pharmacology ANTI-TUMOR Chinese medicine 
New nor-ent-halimane and nor-clerodane diterpenes from Callicarpa integerrima with anti-MRSA activity
《Chinese Journal of Natural Medicines》2024年第11期1003-1010,共8页WANG Mengru WANG Qi MA Yanzi ZEB Muhammad Aurang LI Xiaoli SHEN Feng XIAO Weilie 
supported by the National Natural Science Foundation of China(Nos.22477108,82260682);the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_17R94);the Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform(No.2022YKZY001);the Scientific Research Fund of Yunnan Provincial Department ofEducation(No.2023Y0235)。
Two new nor-ent-halimane diterpenes and three previously unreported nor-clerodane diterpenes,designated callicain-tides A-E(1-5),were isolated from Callicarpa integerrima.Compounds 1 and 2 feature a distinctive 5/6-me...
关键词：Callicarpa integerrima Halimane diterpenes Clerodane diterpenes Structure elucidationanti-MRSA 
Targeted isolation of antiviral cinnamoylphloroglucinol-terpene adducts from Cleistocalyx operculatus by building blocks-based molecular networking approach
《Acta Pharmaceutica Sinica B》2024年第10期4443-4460,共18页Jianguo Song Ruili Huang Jialiao Cai Zhenlong Wu Lijun Hu Wanyang Sun Xiaojun Huang Rongrong He Wei Tang Wencai Ye Ying Wang 
supported by the National Key R&D Program of China(No.2023YFC3503902,China);the National Natural Science Foundation of China(Nos.82293681(82293680);82321004,82204234,and 82273822,China);the Guangdong Basic and Applied Basic Research Foundation(Nos.2022B1515120015 and 2021A1515111021,China);the Guangdong Major Project of Basic and Applied Basic Research(No.2023B0303000026,China);the Guangdong-Hong Kong-Macao Universities Joint Laboratory for the Internationalization of Traditional Chinese Medicine(No.2023LSYS002,China);the Guangzhou Key Laboratory of Traditional Chinese Medicine&Disease Susceptibility(No.2024A03J090,China);the Science and Technology Projects in Guangzhou(No.202102070001,China);supported by the high-performance computing platform of Jinan University.
The building blocks-based molecular network(BBMN)strategy was applied to the phytochemical investigation of Cleistocalyx operculatus,leading to the targeted isolation of eighteen novel cinnamoylphloroglucinol-terpene ...
关键词：Cleistocalyx operculatus Cinnamoylphloroglucinolterpene adduct Targeted isolation Molecular networking Structure elucidation Cleistoperone A Respiratory syncytial virus Antiviral activity 
Niduenes A-F,six functionalized sesterterpenoids with a pentacyclic 5/5/5/5/6 skeleton from endophytic fungus Aspergillus nidulans
《Chinese Chemical Letters》2024年第9期202-205,共4页Aimin Fu Chunmei Chen Qin Li Nanjin Ding Jiaxin Dong Yu Chen Mengsha Wei Weiguang Sun Hucheng Zhu Yonghui Zhang 
financially supported by the National Key Research and Development Program of China(No.2021YFA0910500);the National Natural Science Foundation of China(Nos.U22A20380,82104028,82173706 and 82373755);Innovative Research Groups of the National Natural Science Foundation of China(No.81721005);the Science and Technology Major Project of Hubei Province(No.2021ACA012);the Fundamental Research Funds for the Central Universities,HUST(No.2021JYCXJJ058)。
Niduenes A-F(1-6),six novel sesterterpenoids with unprecedented 5/5/5/5/6 pentacyclic ring skeleton were isolated from endophytic fungus Aspergillus nidulans.Compounds 1 and 2 represent the first examples of aromatic ...
关键词：Aspergillus nidulans Sesterterpenoids Aromatic sesterterpenoids Structure elucidation Single-crystal X-ray diffraction Biosynthetic pathways 
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