INVADOPODIA

作品数：5被引量：6H指数：2
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Isotoosendanin exerts inhibition on triple-negative breast cancer through abrogating TGF-β-induced epithelial—mesenchymal transition via directly targeting TGFβR1被引量：3
《Acta Pharmaceutica Sinica B》2023年第7期2990-3007,共18页Jingnan Zhang Ze Zhang Zhenlin Huang Manlin Li Fan Yang Zeqi Wu Qian Guo Xiyu Mei Bin Lu Changhong Wang Zhengtao Wang Lili Ji 
financially supported by the National Natural Science Foundation of China(82273994);the leadership in the Science and National Key Research and Development Program of China(2018YFC1707302)。
As the most aggressive breast cancer,triple-negative breast cancer(TNBC) is still incurable and very prone to metastasis.The transform growth factor β(TGF-β)-induced epithelial—mesenchymal transition(EMT) is crucia...
关键词：TNBC Isotoosendanin METASTASIS TGFβR1 Epithelial-mesenchymal transition INVADOPODIA PD-L1 Tumor microenvironment 
PYK2 mediates the BRAF inhibitor (vermurafenib)-induced invadopodia formation and metastasis in melanomas
《Cancer Biology & Medicine》2022年第8期1211-1223,共13页Junling Shen Jilong Yang Lei Sang Rui Sun Weiyu Bai Chao Wang Yan Sun Jianwei Sun 
supported by National Natural Science Foundation of China(Grant Nos.81871990 and 31671448);Yunnan Applicative and Basic Research Program(Grant Nos.2019FY003030 and 202101AV070002);a grant(2019KF006)from Conservation and Utilization of Bio-Resources in Yunnan(YNCUB).
Objective:The BRAF inhibitor,vemurafenib,has been widely used in the treatment of patients with melanoma-bearing BRAFV600E mutations.While the initial response to vemurafenib is usually excellent,the majority of patie...
关键词：STIM1 PYK2 INVADOPODIA INVASION MELANOMA VEMURAFENIB 
Compressive Stress Enhances Invasive Phenotype of Cancer Cells via Piezo1 Activation被引量：1
《医用生物力学》2019年第A01期125-126,共2页Mingzhi Luo Kenneth KYHo Zhaowen Tong Linhong Deng Allen PLiu 
supported by Key Program of NSF of China ( 11532003) to L.D.;NSF-MCB 1561794 to A.P.L.
In this study,we hypothesized that Piezo 1 channels mediate the compression-enhanced invasive phenotype of cancer cells via a caveolae-dependent mechanism.To test this hypothesis,we examined in vitro cultured human br...
关键词：compressive stress CAVEOLAE Piezo1 INVADOPODIA MECHANOTRANSDUCTION 
ERK phosphorylation functions in invadopodia formation in tongue cancer cells in a novel silicate fibre-based 3D cell culture system被引量：2
《International Journal of Oral Science》2018年第4期253-262,共10页Masaharu Noi Ken-Ichi Mukaisho Saori Yoshida Shoko Murakami Shinya Koshinuma Takeshi Adachi Yoshisato Machida Masashi Yamori Takahisa Nakayama Gaku Yamamoto Hiroyuki Sugihara 
To screen for additional treatment targets against tongue cancer, we evaluated the contributions of extracellular signal-related kinase(ERK), AKT and ezrin in cancer development. Immunohistochemical staining showed th...
关键词：ERK phosphorylation functions in invadopodia formation in tongue cancer cells in a novel silicate fibre-based 3D cell culture sy HSC 
Research on the Solution of Cell Invasion Model with Free Boundary
《Open Journal of Applied Sciences》2017年第6期242-261,共20页Rouzimaimaiti Mahemuti Ahmadjan Muhammadhaji Takashi Suzuki 
There are many works (i.e. [1]) aiming to find out numerically how positive feedback affects the formation of invadopodia and invasion of cancer cells;however, studies on the cancer cell invasion model with free bound...
关键词：INVADOPODIA CANCER Stefan PROBLEM Free BOUNDARY 
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