TRANSGENES

作品数：21被引量：76H指数：5
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相关领域：生物学农业科学更多>>
相关作者：龚树生郝瑾刘爽更多>>
相关机构：海德堡大学首都医科大学上海交通大学医学院附属新华医院更多>>
相关期刊：《Chinese Journal of Traumatology》《Open Journal of Genetics》《Science China(Life Sciences)》《Science China Chemistry》更多>>
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Comparative study on the expression characteristics of transgenes inserted into the Gt(ROSA)26Sor and H11 loci in mice
《Acta Biochimica et Biophysica Sinica》2024年第11期1687-1698,共12页Zhilan Yu Jiahao Shi Jingyu Zhang Youbing Wu Ruling Shen Jian Fei 
This work was supported by the grants from the National Key R&D Program of China(No.2019YFA0905900);the Science and Technology Commission of Shanghai Municipality(No.18DZ2293500);the Shanghai Engineering Research Center for Model Organisms(No.19DZ2280500);the Science and Technology Commission of Shanghai Municipality(Nos.22140900102 and 201409001900);the Shanghai Laboratory Animal Research Center(No.2023NS01).
The Gt(ROSA)26Sor(ROSA26)and H11 loci are commonly used as safe harbors for the construction of targeted transgenic mice.However,it remains unclear whether these two loci have distinct effects on transgene expression....
关键词：transgenic mouse knockin Gt(ROSA)26Sor H11 gene expression 
Expression profiling of transgenes(Cry1Ac and Cry2A) in cotton genotypes under different genetic backgrounds被引量：1
《Journal of Integrative Agriculture》2022年第10期2818-2832,共15页Kashif NOOR Hafiza Masooma Naseer CHEEMA Asif Ali KHAN Rao Sohail Ahmad KHAN 
Higher Education Commission,Pakistan for providing funds。
Transgenic cotton carrying the CrylAc gene has revolutionized insect pest control since its adoption,although the development of resistance in insect pests has reduced its efficacy.After 10 years of cultivating Bacill...
关键词：transgenic cotton breeding transgene expression double gene insect resistance 
Advances in plastid transformation for metabolic engineering in higher plants
《aBIOTECH》2022年第3期224-232,共9页Sheng Yang Yi Deng Shengchun Li 
supported by the National Natural Science Foundation of China(32071477);Key Research and Development Program of Hubei Province(2021BBA224);Innovation Base for Introducing Talents of Discipline of Hubei Province(2019BJH021,2021EJD025).
The plastid(chloroplast)genome of higher plants is an appealing target for metabolic engineering via genetic transformation.Although the bacterial-type plastid genome is small compared with the nuclear genome,it can a...
关键词：Plastid transformation Metabolic engineering Multiple transgenes High-level expression 
Fitness of F1 hybrids between stacked transgenic rice T1c-19 with cry1C*/bar genes and weedy rice被引量：3
《Journal of Integrative Agriculture》2019年第12期2793-2805,共13页HUANG Yao WANG Yuan-yuan QIANG Sheng SONG Xiao-ling DAI Wei-min 
financially supported by the China Transgenic Organism Research and Commercialization Project (2016ZX08011-001)
Compared to single-trait transgenic crops, stacked transgenic plants may be more prone to become weedy, and transgene flow from stacked transgenic plants to weedy relatives may pose a potential environmental risk beca...
关键词：weedy RICE HYBRIDS stacked TRANSGENES safety assessment FITNESS 
Efficacy of insect-resistance Bt/Cp TI transgenes in F5–F7generations of rice crop–weed hybrid progeny: implications for assessing ecological impact of transgene flow被引量：9
《Science Bulletin》2015年第18期1563-1571,共9页Xiao Yang Lei Li Xing Xing Cai Feng Wang Jun Su Bao-Rong Lu 
supported by the the National Basic Research Program of China(2011CB100401);the National Natural Science Foundation of China(31330014,31271683);National Program of Development of Transgenic New Species of China(2013ZX08011-006)
Ecological impact of transgene flow into pop- ulations of wild/weedy relatives is associated with fitness effects in hybrid progeny. Most studies assessing fitness effects focus essentially on early-generation hybrid ...
关键词：Introgressiogeneration Insect-resistance transgenen Weedy rice FITNESS Advanced Risk assessment 
Tricistronic hepatitis C virus subgenomic replicon expressing double transgenes
《World Journal of Gastroenterology》2014年第48期18284-18295,共12页Xin Cheng Xiang-Cui Gao Jun-Ping Wang Xin-Ying Yang Yan Wang Bao-Sheng Li Fu-Biao Kang Hai-Jun Li Yue-Min Nan Dian-Xing Sun 
Supported by Grants from the Study on Prevention and Control of Viral Hepatitis in the Key Program for Science and Technology Development of Hebei Province,No.10276102D
AIM: To construct a tricistronic hepatitis C virus (HCV) replicon with double internal ribosome entry sites (IRESes) of only 22 nucleotides for each, substituting the encephalomyocarditis virus (EMCV) IRESes, which ar...
关键词：HEPACIVIRUS REPLICON Internal ribosome entry site Tricistronic expression 
Segregation distortion affected by transgenes in early generations of rice crop-weed hybrid progeny: Implications for assessing potential evolutionary impacts from transgene flow into wild relatives被引量：5
《Journal of Systematics and Evolution》2014年第4期466-476,共11页Chao YANG Zhe WANG Xiao YANG Bao-Rong LU 
This work was funded by the '973' program of the Chinese Ministry of Science and Technology，the National Natural Science Foundation of China，the National Program of Development of Transgenic New Species of China
The significant role of segregation distortion as a driving force of evolution has increasingly gained recognition worldwide. Segregation distortion of parental alleles is commonly reported in hybrid progeny between c...
关键词：crop-weed hybridization distorted segregation MICROSATELLITE ORYZA selection transgene introgression 
pH-responsive magnesium- and carbonate-substituted apatite nano-crystals for efficient and cell-targeted delivery of transgenes
《Open Journal of Genetics》2013年第2期38-44,共7页Ezharul Hoque Chowdhury 
The short half-lives due to the enzymatic degradation in blood, the lack of tissue targetability and the incapability to passively diffuse across the plasma membrane and smoothly traffic across the harsh intracelluar ...
关键词：GENE Therapy Nanoparticles Particle Dissolution Ca/Mgpi CARBONATE APATITE ENDOSOME Nucleus GENE Expression 
A New β-Estradiol-lnducible Vector Set that Facilitates Easy Construction and Efficient Expression of Transgenes Reveals CBL3-Dependent Cytoplasm to Tonoplast Translocation of CIPK5被引量：3
《Molecular Plant》2013年第6期1814-1829,共16页Kathrin Schliicking Kai H. Edel Maria M. Drerupa Philipp Koster Christian Eckert Leonie Steinhorst Rainer Waadt Oliver Batistic Jorg Kudla 
Transient and stable expression of transgenes is central to many investigations in plant biology research. Chemical regulation of expression can circumvent problems of plant lethality caused by constitutive overexpres...
关键词：VECTOR inducible gene expression βestradiol Arabidopsis CBL CIPK. 
Gene therapy: light is finally in the tunnel被引量：9
《Protein & Cell》2011年第12期973-989,共17页Huibi Cao Robert S.Molday Jim Hu 
Research in our laboratories was supported by Operating Grants from the Canadian Institutes of Health Research,the Canadian Cystic Fibrosis Foundation,and the Foundation Fighting Blindness-Canada.
After two decades of ups and downs,gene therapy has recently achieved a milestone in treating patients with Leber’s congenital amaurosis(LCA).LCA is a group of inherited blinding diseases with retinal degeneration an...
关键词：gene therapy TRANSGENES viral vector non-viral vector helper-dependent adenoviral vector adenoassociated virus LENTIVIRUS cystic fibrosis transmembrane conductance regulator(CFTR) host immune responses 
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