supported by the Natural Science Foundation of Heilongjiang Province,China (No.LH2021F043);the National Natural Science Foundation of China (No.61702141).
Drug addiction is a complex brain disease closely related to the expression and methylation of many genes.Differential genes can influence addiction,and some key differential genes may have a significant impact on the...
supported by the National Natural Science Foundation of China(82472802 and 82073258);Natural Science Foundation of Shanghai(23ZR1448600).
Acute myeloid leukemia(AML)is a devastating disease with a median age of diagnosis of over 60 years.Thus,most AML patients are not eligible for intensive chemotherapy.Relapse remains common in patientswith AML despite...
Nigeria has a very high number of sickle cell disease (SCD) population with addition of 150,000 babies born annually with the disease. Early infant diagnosis and good care make many of these babies survive to adulthoo...
Supported by the National Natural Science Foundation of China,No.81602056 and No.82273393;the Natural Science Foundation of Shandong Province,No.ZR2016HQ45 and No.ZR2020LZL004;the Shandong Traditional Chinese Medicine Science and Technology Project,No.2021M161.
Pancreatic cancer remains one of the most lethal diseases worldwide owing to its late diagnosis,early metastasis,and poor prognosis.Because current therapeutic options are limited,there is an urgent need to investigat...
This work was supported by the National Natural Science Foundation of China(81988101,81830086 and 81972243);the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-081);Funding by the Major Program of Shenzhen Bay Laboratory(S201101004);the Guangdong Basic and Applied Basic Research Foundation(2019B030302012);the Fund of“San-ming”Project of Medicine in Shenzhen(No.SZSM201812088).
Tumor cell dependence on activated oncogenes is considered a therapeutic target,but protumorigenic microenvironment-mediated cellular addiction to specific oncogenic signaling molecules remains to be further defined.H...
Fondazione Italiana per la Ricerca sul Cancro(project code:AIRC IG21772).
Dear Editor Aberrant gene expression sustains massive proliferation and stress adaptation under the regulation of oncogenic transcription factors(TFs)whose binding across the genome orchestrates in space and time tran...
Supported by The Municipal Natural Science Foundation of Beijing,China,No.7192085;National Science and Technology Major Project of China,No.2018ZX10302206-003-007 and No.2017ZX10203202-001-005;The Capital Health Research and Development of Special,No.2018-1-3011;National Natural Science Foundation of China,No.81470877.
Hepatocellular carcinoma(HCC)is one of the most prevalent cancers worldwide,accounting for approximately 75%-85%of primary liver cancers.Metabolic alterations have been labeled as an emerging hallmark of tumors.Specia...
Circular RNA is a type of non-coding RNA which forms a loop structure.CircRNA was reported to exhibit cell-and tissue-specific patterns.Although accumulating evidences have showed circRNA plays an important role in ne...
supported by the Intramural Research Program of the Center for Cancer Research;National Cancer Institute,National Institutes of Health(ZIA BC 011191).
Dysregulation of genes perpetuates cancer progression.During carcinogenesis,cancer cells acquire dependency of aberrant transcriptional programs(known as“transcription addiction”)to meet the high demands for uncontr...
This review serves to analyze the relationship between childhood trauma and addiction;provide an overview of the science behind addiction;analyze issues with current addiction treatment methods and protocols;as well a...