DEMETHYLASE

作品数：87被引量：394H指数：11
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相关领域：医药卫生生物学更多>>
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相关机构：郑州大学第一附属医院郑州大学西北妇女儿童医院西南大学更多>>
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The RNA N^(6)-methyladenosine demethylase ALKBH9B modulates ABA responses in Arabidopsis被引量：6
《Journal of Integrative Plant Biology》2022年第12期2361-2373,共13页Jun Tang Junbo Yang Qiang Lu Qian Tang Shuyan Chen Guifang Jia 
the Postdoctoral Fellowship of Peking-Tsinghua Center for Life Sciences;supported by the National Natural Science Foundation of China(nos.22225704,21820102008,92053109);the National Basic Research Program of China(2019YFA0802201);the Beijing Natural Science Foundation(Z200010)。
The mRNA modification N^(6)-methyladenosine(m^(6)A)plays vital roles in plant development and biotic and abiotic stress responses.The RNA m^(6)A demethylase ALKBH9 B can remove m^(6)A in alfalfa mosaic virus RNA and p...
关键词：ABA ALKBH9B ARABIDOPSIS DEMETHYLASE m^(6)A RNA modification 
MKRN3 regulates the epigenetic switch of mammalian puberty via ubiquitination of MBD3被引量：7
《National Science Review》2020年第3期671-685,共15页Chuanyin Li Wenli Lu Liguang Yang Zhengwei Li Xiaoyi Zhou Rong Guo Junqi Wang Zhebao Wu Zhiya Dong Guang Ning Yujiang Shi Yinmin Gu Peng Chen Zijian Hao Tianting Han Meiqiang Yang Wei Wang Xuehui Huang Yixue Li Shan Gao Ronggui Hu 
the Strategic PriorityResearch Program of the Chinese Academy of Sciences(XDB19000000 and XDA12040323);the National Natural ScienceFoundation of China(91853128,31470770 and 81525019to R.H.;81773023 to S.G.);the model animal project of ShanghaiScience and Technology Commission(19140903500);theMinistry of Science and Technology of China(2019YFA082103and 2018ZX10101004);China Postdoctoral Science Foundation(2018M642109);the National Natural Science Foundation of China(31900804)to C.L.;supported by the Shanghai Municipal Science andTechnology Major Project(2017SHZDZX01).
Central precocious puberty(CPP)refers to a human syndrome of early puberty initiation with characteristic increase in hypothalamic production and release of gonadotropin-releasing hormone(GnRH).Previously,loss-of-func...
关键词：UBIQUITIN MKRN3 DNA methylation MBD3 DNA DEMETHYLASE central PRECOCIOUS puberty 
Dynamic m^6A modification and its emerging regulatory role in m RNA splicing被引量：3
《Science Bulletin》2015年第1期21-32,共12页杨莹 孙宝发 肖文 杨鑫 孙慧颖 赵永良 杨运桂 
supported by the National BasicResearch Program of China(2011CB510103,2014CB964902);the National Science Foundation of China(91319308,31430022 and31400672);Strategic Priority Research Program of Chinese Academy ofSciences(XDB14030300)
Recent studies on enzymes regulating dynamic N6-methyl-adenosine （m6A） in RNA together with the findings from m6A-methylated RNA immunoprecipitation followed by high-throughput sequencing （MeRIP-seq/m6A- seq） have...
关键词：N6-Methyl-adenosine （m6A） METHYLTRANSFERASE DEMETHYLASE m6A bindingprotein mRNA splicing 
Lysine-specific Demethylase 1 Represses THP-1 Monocyte-to-macrophage Differentiation
《Chinese Medical Sciences Journal》2013年第2期82-87,共6页Rui-feng Yang Guo-wei Zhao Shu-ting Liang Hou-zao Chen De-pei Liu 
Supported by National Natural Science Foundation of China(31271227,30721063,81161120551);National Basic Research Program of China(973 Program,2011CB503902,2011CB965203)
Objective To investigate the role of lysine-specific demethylase 1 （LSD1） in the process of THP-1 monocyte-to-macrophage differentiation. Methods Quantitative reverse transcription-polymerase chain reaction （qRT-...
关键词：lysine-specific demethylase 1 INTERLEUKIN-6 H3K4 methylation monocyte-to-macrophage differentiation 
PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis被引量：7
《Cell Research》2010年第7期794-801,共8页Ziqi Zhu Yanru Wang Xia Li Yiqin Wang Longyong Xu Xiang Wang Tianliang Sun Xiaobin Dong Lulu Chen Hailei Mao Yi Yu Jingsong Li Pin Adele Chen Charlie Degui Chen 
Acknowledgments We thank the cell biology core facility for confocal study. The PHF8 antibody was kindly provided by Dr Jiemin Wong （East China Normal University）. This work was supported by the National Basic Research Program of China （2007CB947900, 2010CB529705, 2007CB947100）, the Chinese Academy of Sci- ences （KSCX2-YW-R-04, KSCX2-YW-R-I 11）, the National Natural Science Foundation of China （30870538, 90919026）, Postdoctoral fellowship （20090460670）, and the Council of Shanghai Municipal Government for Science and Technology.
Dimethylation of histone H3 lysine 9 （H3K9me2） is an important epigenetic mark associated with transcription repression. Here, we identified PHF8, a JmjC-domain-containing protein, as a histone demethylase specific ...
关键词：PHFS histone demethylase H3K9me2 rRNA synthesis 
AOF1 is a histone H3K4 demethylase possessing demethylase activity-independent repression function被引量：6
《Cell Research》2010年第3期276-287,共12页Ze Yang Jun Jiang David M Stewart Shankang Qi Kenichi Yamane Jiwen Li Yi Zhang Jiemin Wong 
We thank Dr Ramin Shiekhattar （Wistar Institute, USA） for the baculoviruses expressing Flag-LSD1 and Drs Jianguo Song and Degui Chen （Shanghai Institute of Biochemistry and Cell Biol- ogy, China） for anti-HDAC1 antibody and H3K36me2 antibody, respectively. This study was partially supported by grants from the National Natural Science Foundation of China （90919025, 30871381）, the Ministry of Science and Technology of China （2009CB918402, 2009CB825601） and the Research Platform for Cell Signaling Networks from the Science and Technology Com- mission of Shanghai Municipality （06DZ22923）.
LSD1 （KDM1 under the new nomenclature） was the first identified lysine-specific histone demethylase belonging to the flavin-dependent amine oxidase family. Here, we report that AOF1 （KDM1B under the new nomenclatur...
关键词：AOF1 histone H3K4 demethylase CHROMATIN REPRESSION Zf-CW 
JMJ14 is an H3K4 demethylase regulating flowering time in Arabidopsis被引量：14
《Cell Research》2010年第3期387-390,共4页Falong Lu Xia Cui Shuaibin, Zhang Chunyan Liu Xiaofeng Cao 
We thank Dr T Jenuwein for providing us the H3K27me3 antibody and Qingbao Zhu for technical support. We thank the Arabidopsis Biological Resources Center at Ohio State for providing SALK T-DNA-insertion lines. This work was supported by grants from the National Basic Research Program of China （2009CB941500 and 2005CB522400 to XC） and the National Natural Science Foundation of China （30771209 to CL, and 30930048 and 30921061 to XC）.
Histone lysine methylation plays an essential role in regulating chromatin functions such as transcription and heterochromatin formation. Histone H3 lysine 4 （H3K4） methylation is linked to active transcription [1, ...
关键词：开花时间 拟南芥 组蛋白甲基化 组蛋白H3 蛋白质家族 调控 转录活性 哺乳动物 
Current Perspectives on Histone Demethylases被引量：1
《Acta Biochimica et Biophysica Sinica》2007年第2期81-88,共8页Xiaoqing TIAN Jingyuan FANG 
This work was supported by the grants from the National Basic Research Program of China(No.2005CB522400);Shanghai Leading Academic Discipline Project(No.Y0205);shanghai Municipal Commission for Science and Technology(No.04DZ14006)
The posttranslational modification of histones plays an important role in chromatin regulation. Histone methylation influences constitutive heterochromatin, genomic imprinting, X-chromosome inactivation and gene trans...
关键词：epigenetic modification histone methylation DEMETHYLASE lysine specific demethylase 1 JumonjiC （JmjC） protein 
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