supported by grants from the National Key Research and Development Program of China 2021YFA1100702(to B.Z.);National Natural Science Foundation of China grants 82271792(to L.S.),32200727(to L.S.)and 82071828(to C.S.);Innovation Capability Support Program of Shaanxi Province 2024CX-GXPT-45(to C.S.);Natural Science Foundation of Shaanxi Province 2017JM8148(to Lin Shi);Fundamental Research Funds for the Central Universities xtr072022002(to B.Z.);the National Natural Science Foundation of China 82350114(to L.Z.);the Natural Science Foundation Outstanding Youth Fund of Jiangsu Province BK20220049(to L.Z.);Suzhou Municipal Key Laboratory SZS2023005(to L.Z.).
CD8^(+)T cell immune responses are regulated by multi-layer networks,while the post-translational regulation remains largely unknown.Transmembrane ectodomain shedding is an important post-translational process orchest...
目的探讨去整合素金属蛋白酶10(a disintegrin and metalloprotease 10,ADAM10)和高迁移率族蛋白B1(high mobility group box-1 protein,HMGB1)与声门型喉癌患者病理特征及预后关系分析。方法回顾性收集2017年3月~2020年12月于南京医科...
supported by the National Natural Science Foundation of China,Nos. 82071304 (to QXZ), 81671149 (to QXZ),and 81971179 (to XML);the Natural Science Foundation of Jiangsu Province,Nos. BK20191463 (to XML) and BK20161167 (to QXZ)。
We previously reported that postsynaptic density-93 mediates neuron-microglia crosstalk by interacting with amino acids 357–395 of C-X3-C motif chemokine ligand 1(CX3 CL1) to induce microglia polarization. More impor...
Supported by the National Natural Science Foundation of China(No.31502187);the Natural Science Foundation of Hebei Province(No.C2018407049);the Hebei Provincial Department of Science and Technology(Nos.20286701Z,20567621H);the Talent Engineering Training Funding Project of Hebei Province(No.A201901057)。
Metalloproteases represent a class of extracellular proteases found in Vibrio anguillarum that can generate toxic and pathogenic eff ects in turbot(Scophthalmus maximus).The toxicological eff ect partly results from o...
Objective:To isolate,purify,and characterize gossypol from the fruits of Thespesia populnea(L)Sol.ex Correa,test its antidermatophytic activity,identify its targets on the dermatophyte,and confirm the binding of gossy...
funded by the Key Sci-Tech Program of China(2016ZX08002-001-004)。
Wheat(Triticum aestivum L.)is an important staple crop for global human.The necrotrophic fungus Rhizoctonia cerealis is the causal pathogen of sharp eyespot,a devastating disease of wheat.Herein,we identified RcMEP1,a...
Necroptosis is a programmed, caspase-independent cell death that is morphologically similar to necrosis. TNF-induced necroptosis is mediated by receptor-interacting protein kinases, RIP1 and RIP3, and the mixed lineag...
Objective To investigate the inhibitory effect of a disintegrin and metalloprotease 12 silenced by shR-NA on self-renewal capacity of CD133 positive giloma cells.Methods The shRNA recombinant lentivirus aimed at silen...
喉癌约占头颈恶性肿瘤的7.9%~35%[1],喉咽癌约占头颈部恶性肿瘤的1.4%~5.0%[1]。解聚素金属蛋白酶17(A disintegrin and metalloprotease 17,ADAM17),最初由Black等[2]和Moss等[3]两个独立的小组同时发现,又称肿瘤坏死因子α转换酶(t...