DESATURASE

作品数：25被引量：80H指数：6
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相关领域：生物学更多>>
相关作者：马超陈利珍江贤章金双侠黄建忠更多>>
相关机构：华中农业大学工业微生物教育部工程研究中心西北农林科技大学北京农业生物技术研究中心更多>>
相关期刊：《畜牧兽医学报》《World Journal of Gastrointestinal Surgery》《World Journal of Hepatology》《Journal of Integrative Agriculture》更多>>
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Ecological immunology:do sexual attraction and immunity trade-off through a desaturase?
《Insect Science》2025年第1期290-300,共11页Ke Gao Wout van der Heide Daphne Muijderman Sarah Nichols Carmen Karwal Peter Kuperus Astrid T.Groot 
funded in part by the National Science Foundation(NSF)grant(IOS-1456973);the Netherlands organization for Scientific Research,the Netherlands(NWO-ALW,822.01.012 and ALWOP 2015.075);the China Scholarship Council(CSC)scholarship(no.201506300162);the University of Amsterdam.
Given the limited availability of resources in nature,sexual attractiveness may trade off with immunocompetence,as the immunocompetence handicap hypothesis(ICHH)posits.In invertebrates,a direct link between trade-offs...
关键词：Chloridea virescens delta-11-desaturase ICHH parasite susceptibility sex pheromone 
High expression of stearoyl-coenzyme A desaturase in colorectal cancer oncogenic functions and its potential as a therapeutic target
《World Journal of Gastrointestinal Surgery》2025年第2期247-264,共18页Xiao-Wei Wang Wan-Ying Huang Kai Qin Da-Tong Zeng Zu-Yuan Chen Bang-Teng Chi Yu-Xing Tang Qi Li Bin Li Dong-Ming Li Rong-Quan He Wei-Jian Huang Gang Chen Rui-Xue Tang Zhen-Bo Feng 
Supported by Natural Science Foundation of Shandong Province,No.ZR2020QH185;Scientific Research Nurturing Fund of the First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital,No.QYPY2020NSFC0803;Guangxi Zhuang Autonomous Region Health Commission Scientific Research Project,No.Z20210442.
BACKGROUND The stearoyl-coenzyme A desaturase(SCD)gene influences colorectal cancer(CRC)pathogenesis,with its expression linked to tumor cell survival and resistance,necessitating further investigation into its role i...
关键词：Colorectal cancer Stearoyl-coenzyme A desaturase Nitidine chloride Molecular docking Standardized mean difference 
Intestinal stearoyl-coenzyme A desaturase-inhibition improves obesity-associated metabolic disorders
《Acta Pharmaceutica Sinica B》2025年第2期892-908,共17页Yangliu Xia Yang Zhang Zhipeng Zhang Nana Yan Vorthon Sawaswong Lulu Sun Wanwan Guo Ping Wang Kristopher W.Krausz Oksana Gavrilova James M.Ntambi Haiping Hao Tingting Yan Frank J.Gonzalez 
supported by the National Cancer Institute Intramural Research Program,CCR,CIL,the Natural Science Foundation of Jiangsu Province(BK20241592,China)to Tingting Yan;National Natural Science Foundation of China(No.82404732 to Tingting Yan,No.81930109 and 82321005 to Haiping Hao,No.82370848 and HY2022-7 to Lulu Sun,No.62173005 to Zhipeng Zhang);the Project of State Key Laboratory of Natural Medicines,China Pharmaceutical University(SKLNMZZ202402 to Haiping Hao,China);National Institutes of Health,National Institute of Diabetes and Digestive and Kidney Diseases(DK118093 to James N.Ntambi,USA);supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development(NICHD,USA).
Stearoyl-coenzyme A desaturase 1(SCD1)catalyzes the rate-limiting step of de novo lipogenesis and modulates lipid homeostasis.Although numerous SCD1 inhibitors were tested for treating metabolic disorders both in prec...
关键词：OBESITY SCD1 MT1 Intestinal epithelium High-fat diet Oxidative stress STEATOSIS Metabolic disorders 
Meldonium-induced steatosis is associated with increased delta 6 desaturation and reduced elongation of n-6 polyunsaturated fatty acids
《Liver Research》2024年第3期152-164,共13页Bodil Bjørndal Siri Lunde Tungland Pavol Bohov Magne OSydnes Simon N.Dankel Lise Madsen Rolf K Berge 
Background and objective Metabolic associated fatty liver disease(MAFLD)is associated with abnormal lipid metabolism.Mitochondrial dysfunction is considered an important factor in the onset of MAFLD,whereas altered fa...
关键词：STEATOSIS Fatty acid composition Fatty acid oxidation Meldonium DESATURASE Elongasen-6 polyunsaturated fatty acid 
Identification and Expression of PPAR in Sinonovacula constricta and Their Potential Regulatory Effects on Δ6 Fad Transcription
《Journal of Ocean University of China》2021年第6期1557-1566,共10页RAN Zhaoshou KONG Fei LIAO Kai XU Jilin LIU Xingwang SHI Peng ZHANG Mengqi WU Kaibin YAN Xiaojun 
the National Key Re-search and Development Program of China(No.2019YF D0900400);the Zhejiang Major Science Project,China(No.2019C02057);the Ningbo Science and Technology Re-search Projects,China(Nos.202003N4124,2019B10006);the China Agriculture Research System of MOF and MARA,and the Open Project Funding of‘National and Local Joint Engineering Laboratory of Marine Biotechnology and Engi-neering,Key Laboratory of Applied Marine Biotechnology,Collaborative Innovation Center for Zhejiang Marine High-efficiency and Healthy Aquaculture,and Key Laboratory of Marine Biological Engineering,Zhejiang,China’.
Peroxisome proliferator activated receptors(PPAR)are kinds of key transcriptional factors in regulating LC-PUFA biosynthesis.Until now,little is known about PPAR in marine molluscs as well as in other invertebrates.Si...
关键词：Sinonovacula constricta peroxisome proliferator activated receptors Δ6 fatty acyl desaturase long chain-polyunsaturated fatty acids 
Identification and characterization of stearoyl-CoA desaturase in Toxoplasma gondii
《Acta Biochimica et Biophysica Sinica》2019年第6期615-626,共12页Pan Hao Xia Cui Jing Liu Muzi Li Yong Fu Qun Liu 
This work was supported by the National Key Research and Development Program of China (2017YFD0500400);the National Natural Science Foundation of China (31372424 and 31672544).We greatly appreciate Prof. William J.Sullivan,Jr.(Indiana University,USA) for providing TgIF2a antibodies, whose research was funded by National Institutes of Health grant AI105786.
Few information of the function of stearoyl-coenzyme A (CoA) desaturase (SCD) in apicomplaxan parasite has been obtained. In this study, we retrieved a putative fatty acyl-CoA desaturase (TGGT1_238950) by a protein al...
关键词：TOXOPLASMA GONDII stearoyl-coenzyme A DESATURASE gene EDITING AUTOPHAGY endoplasmic reticulum stress 
Identification and characterization of a delta-12 fatty acid desaturase gene from marine microalgae Isochrysis galbana被引量：1
《Acta Oceanologica Sinica》2019年第2期107-113,共7页Xiaotian Han Shuai Wang Li Zheng Wanshun Liu 
The Basic Scientific Fund for National Public Research Institutes of China under contract No.2017Q09;the Aoshan Science and Technology Innovation Project of Pilot National Laboratory for Marine Science and Technology(Qingdao)under contract No.2016ASKJ02;the National Natural Science Foundation of China-Shandong Joint Funded Project under contract No.U1606404;the National Natural Science Foundation of China under contract Nos 41776176 and 41806201;the 973 Project from Chinese Ministry of Science and Technology under contract No.2015CB755904;the Shandong Provincial Natural Science Foundation under contract No.ZR2015PD003
The cDNA of the delta-12 fatty acid desaturase gene, IgFAD2, was cloned from the marine microalgae Isochrysis galbana, a species capable of producing docosahexaenoic acid. Sequence analysis indicated that the open rea...
关键词：delta-12 FATTY ACID DESATURASE expression analysis ISOCHRYSIS GALBANA 
Functional characterization of a Δ6 fatty acid desaturase gene and its 5′-upstream region cloned from the arachidonic acid-rich microalga Myrmecia incisa Reisigl(Chlorophyta)被引量：1
《Journal of Oceanology and Limnology》2018年第6期2308-2321,共14页ZHANG Li CAO Haisheng NING Pu ZHOU Zhigang 
Supported by the National Natural Science Foundation of China(No.31172389);the Special Project of Marine Renewable Energy from the State Oceanic Administration(No.SHME2011SW02);the Shanghai Universities Peak Discipline Project of Aquaculture
It is suggested that Δ6 fatty acid desaturase(FAD) plays a critical role in the biosynthesis of polyunsaturated fatty acids in plants and microalgae. But why does it adapt to the changed environments such as nitrogen...
关键词：arachidonic acid(ArA) fatty ACID desaturase(FAD) green fl uorescent protein(GFP) green MICROALGA Saccharomyces cerevisiae 5′-upstream region(5′-USR) 
Molecular Cloning and Expression Analysis of the ζ-Carotene Desaturase Gene in Chinese kale(Brassica oleracea var.alboglabra Bailey)被引量：10
《Horticultural Plant Journal》2018年第3期94-102,共9页SUN Bo ZHANG Fen XUE Shengling CHANG Jiaqi ZHENG Aihong JIANG Min MIAO Huiying WANG Qiaomei TANG Haoru 
supported by National Natural Science Foundation of China(31500247);Key Project of Department of Education of Sichuan Province(14ZA0016);Natural Science Foundation of Zhejiang Province(LZ15C150001)
ζ-Carotene desaturase(ZDS)is an important enzyme in carotenoid biosynthesis.Here,the Brassica oleracea var.alboglabra ZDS(Boa ZDS)gene was cloned from Chinese kale via reverse transcription-polymerase chain reaction(...
关键词：Chinese kale Brassica oleracea var alboglabra Bailey carotenoids ζ-carotene desaturase(ZDS) CLONING gene expression prokaryotic expression heterologous expression 
mi R-192-5p regulates lipid synthesis in non-alcoholic fatty liver disease through SCD-1被引量：12
《World Journal of Gastroenterology》2017年第46期8140-8151,共12页Xiao-Lin Liu Hai-Xia Cao Bao-Can Wang Feng-Zhi Xin Rui-Nan Zhang Da Zhou Rui-Xu Yang Ze-Hua Zhao Qin Pan Jian-Gao Fan 
Supported by National Key R&D Program of China No.2017YFC0908900;National Key Basic Research Project,No.2012CB517501;National Natural Science Foundation of China,No.81470840 and No.81600464
AIM To evaluate the levels of mi R-192-5 p in non-alcoholic fatty liver disease(NAFLD) models and demonstrate the role of mi R-192-5 p in lipid accumulation. METHODS Thirty Sprague Dawley rats were randomly divided in...
关键词：mi R-192-5p Stearoyl-Co A desaturase 1 High fat diet Lipid synthesis Non-alcoholic fatty liver disease 
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