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A novel missense mutation of CCDC34 causes male infertility with oligoasthenoteratozoospermia in a consanguineous Pakistani family
《Asian Journal of Andrology》2024年第6期605-609,共5页Nisar Ahmad Meng-Lei Yang Aurang Zeb Jian-Teng Zhou Muhammad Zubair Tanveer Abbas Xiao-Hua Jiang Yuan-Wei Zhang Huan Zhang Wasim Shah Qing-Hua Shi 
supported by the National Natural Science Foundation of China(No.82071709,No.32070850,and No.82171601);the National Key Research and Developmental Program of China(2022YFC2702601 and 2022YFA0806303);the Joint Fund for New Medicine of USTC(YD9100002034).
Male infertility is a worldwide health issue,affecting 8%–12%of the global population.Oligoasthenoteratozoospermia(OAT)represents a severe type of male infertility,characterized by reduced sperm count and motility an...
关键词：CCDC34 consanguineous family male infertility missense mutation OLIGOASTHENOTERATOZOOSPERMIA 
A novel AMH variant at the prehelix loop impairs the binding to AMHR2 and causes persistent Mullerian duct syndrome
《Asian Journal of Andrology》2024年第2期222-224,共3页Qiang Du Chuang Qiu Yuan-Yuan Zhang Xue-Jun Shang Xiao-Liang Liu 
supported by grant from the Natural Science Foundation of Liaoning Province(No.2022 MS 208);the 345 Talent of Shengjing Hospital of China Medical University(No.M1395);the General Project of Shengjing Hospital of China Medical University(No.2023-M 1643).
Dear Editor,Persistent Mullerian duct syndrome(PMDS;Online Mendelian Inheritance in Man[OMIM]:#261550)is a rare autosomal recessive inherent difference in sex development in males with Mullerian duct derivatives,inclu...
关键词：ELEVATED AMH MULLER 
Low XIST expression in Sertoli cells of Klinefelter syndrome patients causes high susceptibility of these cells to an extra X chromosome被引量：1
《Asian Journal of Andrology》2023年第6期662-673,共12页Liang-Yu Zhao Peng Li Chen-Cheng Yao Ru-Hui Tian Yu-Xin Tang Yu-Zhuo Chen Zhi Zhou Zheng Li 
This work was supported by grants from the National Key R&D Program of China(2022YFC2702700);National Natural Science Foundation of China(82201756 and 82171597);China Postdoctoral Science Foundation(2021M703747);GuangDong Basic and Applied Basic Research Foundation(2021A1515111109)。
Klinefelter syndrome(KS)is the most common genetic cause of human male infertility.However,the effect of the extra X chromosome on different testicular cell types remains poorly understood.Here,we profiled testicular ...
关键词：Klinefelter syndrome nonobstructive azoospermia Sertoli cell SPERMATOGENESIS X chromosome inactivation 
Novel mutation in ODF2 causes multiple morphological abnormalities of the sperm flagella in an infertile male被引量：3
《Asian Journal of Andrology》2022年第5期463-472,共10页Zi-Jue Zhu Yi-Zhou Wang Xiao-Bo Wang Chen-Cheng Yao Liang-Yu Zhao Zhen-Bo Zhang Yu Wu Wei Chen Zheng Li 
supported by grant from the National Key Research and Development Program of China(No.2017YFC1002003).
Numerous genes have been associated with multiple morphological abnormalities of the sperm flagella(MMAF),which cause severe asthenozoospermia and lead to male infertility,while the causes of approximately 50%of MMAF ...
关键词：intracytoplasmic sperm injection laser-assisted immotile sperm selection multiple morphological abnormalities of the sperm flagella outer dense fiber protein 2(ODF2) 
A recurrent homozygous missense mutation in CCDC103 causes asthenoteratozoospermia due to disorganized dynein arms被引量：1
《Asian Journal of Andrology》2022年第3期255-259,共5页Muhammad Zubair Ranjha Khan Ao Ma Uzma Hameed Mazhar Khan Tanveer Abbas Riaz Ahmad Jian-Teng Zhou Wasim Shah Ansar Hussain Nisar Ahmed Ihsan Khan Khalid Khan Yuan-Wei Zhang Huan Zhang Li-Min Wu Qing-Hua Shi 
supported by the National Natural Science Foundation of China(No.81971446).
Asthenoteratozoospermia is one of the most severe types of qualitative sperm defects.Most cases are due to mutations in genes encoding the components of sperm flagella,which have an ultrastructure similar to that of m...
关键词：asthenoteratozoospermia CCDC103 dynein arms male infertility 
“Progressive motility”in elucidating novel genetic causes of male infertility
《Asian Journal of Andrology》2022年第3期229-230,F0002,共3页Feng Zhang 
Genetic factors play important roles in the etiology of male infertility.The routine clinical genetic testing for human spermatogenic failure is currently limited to abnormal karyotypes(e.g,47,XXY for Klinefelter synd...
关键词：DATING CHROMOSOMAL ROUTINE 
A new TEX11 mutation causes azoospermia and testicular meiotic arrest被引量：6
《Asian Journal of Andrology》2021年第5期510-515,共6页Xiao-Chen Yu Meng-Jing Li Fei-Fei Cai Si-Jie Yang Hong-Bin Liu Hao-Bo Zhang 
the Key Research and Development Program of Shandong Province(2019GSF108237);the Young Scholars Program of Shandong University(2016WLJH50);the Natural Science Foundation of Shandong Province(ZR2017MH049).
There are many unknown genetic factors that lead to infertility in nonobstructive azoospermia men.Here,we performed whole-exome sequencing in blood samples obtained from 40 azoospermia patients with meiotic arrest and...
关键词：male infertility meiotic arrest nonobstructive azoospermia testis expressed 11 
Sperm retrieval rates and clinical outcomes for patients with different causes of azoospermia who undergo microdissection testicular sperm extraction-intracytoplasmic sperm injection被引量：9
《Asian Journal of Andrology》2021年第1期59-63,共5页Hong-Liang Zhang Lian-Ming Zhao Jia-Ming Mao De-Feng Liu Wen-Hao Tang Hao-Cheng Lin Li Zhang Ying Lian Kai Hong Hui Jiang 
This research was sponsored by the National Key Research and Development Project(SQ2018YFC100243);National Key Research and Development Project(2016YFC1000302);National Key Research and Developmental Program of China(2018YFC1003600);Young Scientists Fund of the National NaturalScience Foundation of China(Grant No.81601272);Clinical MedicinePlusX-Young Scholars Project,Peking University(Grant No.2102018237);Beijing Municipal Natural Science Foundation(7182177);National KeyResearch and Development Program of China(Grant No.2017YFC1002001).
The aim of our study was to compare the sperm retrieval rates(SRRs)and clinical outcomes of patients with different causes of azoospermia who underwent microdissection testicular sperm extraction-intracytoplasmic sper...
关键词：AZOOSPERMIA intracytoplasmic sperm injection microdissection testicular sperm extraction pregnancy outcomes sperm retrieval rate 
The association between the two more common genetic causes of spermatogenic failure:a 7-year retrospective study
《Asian Journal of Andrology》2020年第6期642-648,共7页Hong-Ge Li Li-Hong Fan Bei Liu Ye-Qing Qian Min Chen Yi-Xi Sun Min-Yue Dong 
We should like to thank our patients for agreeing to donate their personal data and allowing the data to be published.We are grateful to Dr.Jiong Gao(BGI Genomics,BGI-Shenzhen,Shenzhen,China)for improving the article.The study was funded by the National Key Research and Development Program of China(Grant No.2018YFC1004903,and 2016YFC1000703);Key Research and Development Program of Zhejiang Province(Grant No.2019C03025);the National Nature Science Foundation of China(Grant No.81801441);and Zhejiang Provincial Natural Science Foundation of China(Grant No.LQ19H090019).
Chromosomal abnormalities and Y chromosome microdeletions are considered to be the two more common genetic causes of spermatogenic failure.However,the relati on ship between chromosomal aberrations and Y chromosome mi...
关键词：azoospermia factor chromosomal aberrations infertile men nonobstructive azoospermia and oligozoospermia spermatogenic failure Y chromosome microdeletions 
Nitrosative stress in human spermatozoa causes cell death characterized by induction of mitochondrial permeability transition-driven necrosis
《Asian Journal of Andrology》2018年第6期600-607,共8页Pamela Uribe Maria E Cabrillana Miguel W Forn Favi/m Treulen Rodrigo Boguen Vladimir Isachenko Evgenia Isachenko Ratil S inchez Juana V Villegas 
Peroxynitrite is a highly reactive nitrogen species and a potent inducer of apoptosis and necrosis in somatic cells. Peroxynitrite-induced nitrosative stress has emerged as a major cause of impaired sperm function; ho...
关键词：NECROSIS nitrosative stress oxidative stress PEROXYNITRITE sperm cell death 
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