PROTEIN-PROTEIN

作品数：47被引量：72H指数：4
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Protein microarray analysis of cytokine expression changes in distal stumps after sciatic nerve transection被引量：3
《Neural Regeneration Research》2020年第3期503-511,共9页Xiao-Qing Cheng Xue-Zhen Liang Shuai Wei Xiao Ding Gong-Hai Han Ping Liu Xun Sun Qi Quan He Tang Qing Zhao Ai-Jia Shang Jiang Peng 
supported by the National Key Research&Development Program of China,No.2017YFA0104702(to AJS);the National Basic Research Program of China(973 Program),No.2014CB542201(to JP)
A large number of chemokines,cytokines,other trophic factors and the extracellular matrix molecules form a favorable microenvironment for peripheral nerve regeneration.This microenvironment is one of the major factors...
关键词：cytokines DISTAL stump gene ontology KYOTO ENCYCLOPEDIA of Genes and Genomes pathway peripheral nerve injury protein microarray PROTEIN-PROTEIN interaction network Wallerian degeneration 
Structural dissection of Hippo signaling
《Acta Biochimica et Biophysica Sinica》2015年第1期29-38,共10页Zhubing Shi Shi Jiao Zhaocai Zhou 
This work was supported by the grants from the 973 program of the Ministry of Science and Technology of China （No. 2012CB910204）, the National Natural Science Foundation of China （Nos. 31270808, 31300734, 31470736, and 31470868）, the Science and Technology Commission of Shanghai Municipality （Nos. 11JC14140000 and 13ZR1446400）, and the ＇Cross and Cooperation in Science and Tech- nology Innovation Team＇ Project of the Chinese Academy of Sciences.
The Hippo pathway controls cell number and organ size by restricting cell proliferation and promot- ing apoptosis, and thus is a key regulator in development and homeostasis. Dysfunction of the Hippo pathway correlate...
关键词：Hippo pathway three-dimensional structure protein-protein/DNA interaction regulatory mechanism 
Protein-protein complexation in bioluminescence
《Protein & Cell》2011年第12期957-972,共16页Maxim S.Titushin Yingang Feng John Lee Eugene S.Vysotski Zhi-Jie Liu 
by“Fellowship for Young International Scientists”of Chinese Academy of Sciences;This work was supported by the National Natural Science Foundation of China(Grant Nos:30870483,31070660,31021062 and 81072449);Ministry of Science and Technology of China(Nos.2009DFB30310,2009CB918803 and 2011CB911103);CAS Research Grants(Nos.YZ200839 and KSCX2-EW-J-3).
In this review we summarize the progress made towards understanding the role of protein-protein interactions in the function of various bioluminescence systems of marine organisms,including bacteria,jellyfish and soft...
关键词：green-fluorescent protein(GFP) PHOTOPROTEIN LUCIFERASE lumazine protein Förster resonance energy transfer(FRET) DOCKING 
A holistic molecular docking approach for predicting protein-protein complex structure被引量：2
《Science China(Life Sciences)》2010年第9期1152-1161,共10页GONG XinQi LIU Bin CHANG Shan LI ChunHua CHEN WeiZu WANG CunXin 
supported by grants from the National Natural Science Foundation of China (Grant Nos. 10974008 and 20773006);the Specialized Research Fund for the Doctoral Program of Higher Education (Grant No. 200800050003);the National Basic Research Program of China (Grant No. 2009CB930200);the Beijing Natural Science Foundation (Grant No. 4102006)
A holistic protein-protein molecular docking approach,HoDock,was established,composed of such steps as binding site prediction,initial complex structure sampling,refined complex structure sampling,structure clustering...
关键词：PROTEIN-PROTEIN complex structure prediction BINDING SITE molecular DOCKING CAPRI 
Structure-function studies of the influenza virus RNA polymerase PA subunit被引量：8
《Science China(Life Sciences)》2009年第5期450-458,共9页Mark BARTLAM 
Supported by the National Natural Science Foundation of China (Grant No. 30599432);National Key Basic Research Program of China (Grant Nos. 2006 CB10901, 2006CB806503, 2007CB914301, 2006AA02A300 and 2007CB914304)
The influenza virus RNA-dependent RNA polymerase is a heterotrimeric complex (PA, PB1 and PB2) with multiple enzymatic activities for catalyzing viral RNA transcription and replication. The roles of PB1 and PB2 have b...
关键词：INFLUENZA POLYMERASE PA SUBUNIT crystal structure ENDONUCLEASE PROTEIN-PROTEIN interaction 
Identifying drug-target proteins based on network features被引量：3
《Science China(Life Sciences)》2009年第4期398-404,共7页ZHU MingZhu1, GAO Lei1, LI Xia1,2 & LIU ZhiCheng1 1 School of Biomedical Engineering, Capital Medical University, Beijing 100069, China 2 College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China 
Supported by National Natural Science Foundation of China (Grant No. 30370798, 30571034 and 30570424);National High-Tech Research and Development Program of China (Grant No. 2007AA02Z329);National Basic Research Program of China (Grant No. 2008CB517302); Natural Science Foundation of Heilongjiang Province, China (Grant No. ZJG0501, 1055HG009, GB03C602-4 and BMFH060044); New Century Hundred-Thousand-Ten Thousand Talents Project of Beijing City, Scientific Research Common Program of Beijing Municipal Commission of Education (KM200610025011).
Proteins rarely function in isolation inside and outside cells, but operate as part of a highly intercon- nected cellular network called the interaction network. Therefore, the analysis of the properties of drug-targe...
关键词：drug-target PROTEIN-PROTEIN INTERACTION TOPOLOGICAL FEATURES 
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