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Maternal high-fat diet impairs offspring glucose metabolism and programs hepatic DNA methylation linked to NK cell-mediated cytotoxicity signaling pathway at weaning
《Food Science and Human Wellness》2025年第4期1576-1587,共12页Sheng Zheng Ling Zhang Shixuan Zhang Guanyu Hu Yikai Li Jia Zheng 
sponsored by National Natural Science Foundation of China(81800703);Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(GZC20231088);Beijing Nova Program(Z201100006820117 and 20220484181);Beijing Municipal Natural Science Foundation(7184252);the Fundamental Research Funds for the Central Universities;the Fundamental Research Funds for the Central Universities(BMU2021MX013);Peking University Clinical Scientist Training Program(BMU2023PYJH022);Peking University Medicine Seed Fund for Interdisciplinary Research;China Endocrine and Metabolism Young Scientific Talent Research Project(2022-N-02-01);China Diabetes Young Scientific Talent Research Project;Bethune-Merck Diabetes Research Fund of Bethune Charitable Foundation。
Maternal consumption of a high-fat diet has been linked to increased risks of obesity and impaired glucose metabolism in offspring.However,the precise epigenetic mechanisms governing these intergenerational effects,pa...
关键词：Maternal high-fat diet consumption Glucose metabolism DNA methylation Natural killer cell-mediated cytotoxicity WEANING 
Maternal sleep deprivation disrupts glutamate metabolism in offspring rats
《Zoological Research》2024年第6期1221-1231,共11页Wen-Ting He Dong-Xu Li Jin-Hua Fan Zheng-Yu Yao Yu-Peng Cun Zhi-Fang Dong 
supported by the National Natural Science Foundation of China(32371030,82071395);Natural Science Foundation of Chongqing(CSTB2024NSCQ-LZX0008);Science and Technology Research Program of Chongqing Municipal Education Commission(KJQN202300424);CQMU Program for Youth Innovation in Future Medicine(W0044)。
Maternal sleep deprivation(MSD)has emerged as a significant public health concern,yet its effects on offspring metabolism remain poorly understood.This study investigated the metabolomic implications of MSD on offspri...
关键词：Maternal sleep deprivation Glutamate metabolism Metabolomics Cognitive development OFFSPRING 
Maternal diseases and congenital anomalies of the kidney and urinary tract in offspring: a cohort study被引量：2
《World Journal of Pediatrics》2024年第11期1168-1178,共11页Qiang Ma Ya-Qi Li Qing-Tang Meng Bo Yang Hai-Tao Zhang Hua Shi Chang-You Liu Tian-Chao Xiang Na Zhao Jia Rao 
supported by the National Key Research and Development Program of China(2021YFC2701101,to RJ);the Program of Shanghai Academic/Technology Research(23141900700,to RJ).
Background Congenital anomalies of the kidneys and urinary tract(CAKUT)are the most common cause of prenatally diagnosed developmental malformation.This study aimed to assess the relationship between maternal diseases...
关键词：Congenital anomalies of the kidney and urinary tract(CAKUT) Kidney anomalies Predictive model Risk factors Urinary tract dilation(UTD) 
The transgenerational effects of maternal low-protein diet during lactation on offspring
《Journal of Genetics and Genomics》2024年第8期824-835,共12页Lin-Jian Gu Li Li Qian-Nan Li Ke Xu Wei Yue Jing-Yi Qiao Tie-Gang Meng Ming-Zhe Dong Wen-Long Lei Jia-Ni Guo Zhen-Bo Wang Qing-Yuan Sun 
supported by the National R&D program of China(2022YFC2703500);the Science and Technology Program of Guangzhou,China(202201020292 and 2023A03J0258);the Natural Science Foundation of Shandong Province(ZR2021ZD33);the Strategic Collaborative Research Program of the Ferring Institute of Reproductive Medicine,Ferring Pharmaceuticals and Chinese Academy of Sciences(FIRMC181101).
Environmental factors such as diet and lifestyle can influence the health of both mothers and offspring.However,its transgenerational transmission and underlying mechanisms remain largely unknown.Here,using a maternal...
关键词：Lactationdiet Maternal low-proteindiet DNAMETHYLATION Transgenerational effect OOCYTE 
Gastrointestinal problems in a valproic acid-induced rat model of autism: From maternal intestinal health to offspring intestinal function
《World Journal of Psychiatry》2024年第7期1095-1105,共11页Sha Li Nan Zhang Wang Li Han-Lai Zhang Xiao-Xi Wang 
Supported by the National Natural Science Foundation of China,No.82305035.
BACKGROUND Autism spectrum disorder(ASD)is a developmental disorder characterized by social deficits and repetitive behavior.Gastrointestinal(GI)problems,such as constipation,diarrhea,and inflammatory bowel disease,co...
关键词：Autism spectrum disorder Gastrointestinal problems Gut microbiota Intestinal inflammation Intestinal motility 
The impact of maternal immune activation on the morphology and electrophysiological properties of postnatally-born neurons in the offspring
《Neural Regeneration Research》2024年第2期399-400,共2页Emilio J.Galván Angelica Zepeda 
supported by Dirección General del Personal Académico(DGAPA)PAPIIT IN207123,UNAM(to AZ)。
Pregnancy comes with a combination of physical changes and physiological immunosuppression that increases the susceptibility of women to pathogens and in turn,rises the prevalence of infectious diseases.
关键词：PREVALENCE ACTIVATION impact 
Maternal Bisphenol B Exposure and Mammary Gland Development of Offspring:A Time-Series Analysis
《Environment & Health》2023年第4期278-290,共13页Xiaotong Ji Peiyun Jiang Yating Li Lihong Su Huifeng Yue Nan Sang 
supported by National Science Foundation of China(Nos.22106098,21906099,and 22036005);Youth Science and Technology Research Foundation of Shanxi Province(20210302124298);Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(2020L0174);Startup Foundation for Doctors of Shanxi Province(SD1917);Startup Foundation for Doctors of Shanxi Medical University(XD1917).
Breast cancer incidence has increased and become the world’s most prevalent cancer,which is related to abnormal development of mammary glands and thought to be influenced by environment endocrine disruptors such as b...
关键词：Bisphenol B Maternal exposure Mammary gland development Hormonal homeostasis Progesterone receptor 
Maternal aging increases offspring adult body size via transmission of donut-shaped mitochondria
《Cell Research》2023年第11期821-834,共14页Runshuai Zhang Jinan Fang Ting Qi Shihao Zhu Luxia Yao Guicun Fang Yunsheng Li Xiao Zang Weina Xu Wanyu Hao Shouye Liu Dan Yang Di Chen Jian Yang Xianjue Ma Lianfeng Wu 
supported by HRHI program (202209008)of Westlake Laboratory of Life Sciences and Biomedicine,Westlake Education Foundation,the National Natural Science Foundation of China (32071151,32170824,32271357);the Natural Science Foundation of Zhejiang Province (2022XHSJJ005);the"Pioneer"and"Leading Goose"R&D Program of Zhejiang (022SDXHDX0001);the“Team for Growth Control and Size Innovative Research” (201804016).
Maternal age at childbearing has continued to increase in recent decades.However,whether and how it influences offspring adult traits are largely unknown.Here,using adult body size as the primary readout,we reveal tha...
关键词：size ADULT TOGETHER 
Association between maternal gestational diabetes and allergic diseases in offspring:a birth cohort study
《World Journal of Pediatrics》2023年第10期972-982,共11页Yu-Jing Chen Li-Zi Lin Zhao-Yan Liu Xin Wang Shamshad Karatela Yu-Xuan Wang Shan-Shan Peng Bi-Bo Jiang Xiao-Xu Li Nan Liu Jin Jing Li Cai 
supported by the Key-Area Research and Development Program of Guangdong Province(2019B030335001);the Natural Science Foundation of Guangdong Province,China(2023A1515030192);the“Nutrition and Care of Maternal&Child Research Fund Project”of Biostime Institute of Nutrition&Care(2021BINCMCF053).
Background Previous studies have linked gestational diabetes(GDM)with allergies in offspring.However,the effect of specific glucose metabolism metrics was not well characterized,and the role of polyunsaturated fatty a...
关键词：Allergic disease Cohort study ECZEMA Gestational diabetes Polyunsaturated fatty acid 
Maternal sodium acetate supplementation promotes lactation performance of sows and their offspring growth performance
《Animal Nutrition》2023年第3期213-224,共12页Yingao Qi Tenghui Zheng Siwang Yang Qianzi Zhang Baofeng Li Xiangfang Zeng Yongxing Zhong Fang Chen Wutai Guan Shihai Zhang 
financially supported by the National Key R&D Program of China(2021YFD1300700);Guangdong Basic and Applied Basic Research Foundation(2021A1515010440 and 2023A1515012098);Science and Technology Program of Guangzhou(202102020056)。
Milk yield and composition are critical determining factors for the early growth and development of neonates.The objective of this experiment was to comprehensively evaluate the effects of dietary sodium acetate(SA)su...
关键词：SOW Sodium acetate Lactation performance Milk fat Gut health 
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