Γ-SECRETASE

作品数：23被引量：59H指数：5
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相关领域：医药卫生更多>>
相关作者：殷莹曹鹏缪凤琴于春泳梁国标更多>>
相关机构：东南大学清华大学第二军医大学台湾大学更多>>
相关期刊：《National Science Review》《Advances in Bioscience and Biotechnology》《Acta Biochimica et Biophysica Sinica》《Medicinal Plant》更多>>
相关基金：国家自然科学基金World Health Organization更多>>
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Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease
《Neural Regeneration Research》2025年第1期174-180,共7页Yinglong Miao Michael S.Wolfe 
supported in part by Award 2121063 from National Science Foundation(to YM);AG66986 from the National Institutes of Health(to MSW).
γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the ...
关键词：Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics NOTCH 
CNTNAP2 intracellular domain(CICD)generated byγ-secretase cleavage improves autism-related behaviors被引量：2
《Signal Transduction and Targeted Therapy》2023年第7期3415-3426,共12页Jing Zhang Fang Cai Renbin Lu Xiaoliang Xing Lu Xu Kunyang Wu Zishan Gong Qing Zhang Yun Zhang Mengen Xing Weihong Song Jia-Da Li 
This work was supported by funding from National Natural Science Foundation of China(NSFC),Grant/Award Number:81770780 and 31972913;Key Research and Development Programs from Hunan Province,Grant/Award Number:2021DK2001;Guangdong Key Project in‘Development of New Tools for Diagnosis and Treatment of Autism’,Grant/Award Number:2018B030335001;Strategic Priority Research Program of Central South University,Grant/Award Number:ZLXD2017004;The project has been funded in part with Independent Exploration and Innovation Project of Central South University,Grant/Award Number:2018zzts393.
As the most prevalent neurodevelopmental disorders in children,autism spectrum disorders(ASD)are characterized by deficits in language development,social interaction,and repetitive behaviors or inflexible interests.Co...
关键词：BEHAVIORS CLEAVAGE RESIDUES 
Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease
《Neural Regeneration Research》2022年第1期31-37,共7页Mercedes A.Hernández-Sapiéns Edwin E.Reza-Zaldívar Ana L.Márquez-Aguirre Ulises Gómez-Pinedo Jorge Matias-Guiu Ricardo R.Cevallos Juan C.Mateos-Díaz Víctor J.Sánchez-González Alejandro A.Canales-Aguirre 
supported by the Consejo Nacional de Ciencia y Tecnología Scholarship 711893(to MAH)and 711874(to EER)。
The presenilin genes(PSEN1 and PSEN2)are mainly responsible for causing early-onset familial Alzheimer’s disease,harboring~300 causative mutations,and representing~90%of all mutations associated with a very aggressiv...
关键词：familial Alzheimer’s disease familial Alzheimer’s disease-induced pluripotent stem cells models induced pluripotent stem cells neurogenesis neuronal differentiation Notch presenilin 1 PSEN1 mutations γ-secretase complex 
Critical thinking on amyloid-beta-targeted therapy:challenges and perspectives被引量：8
《Science China(Life Sciences)》2021年第6期926-937,共12页Bin-Lu Sun Yang Chen Dong-Yu Fan Chi Zhu Fan Zeng Yan-Jiang Wang 
supported by the National Natural Science Foundation of China(91749206,81930028,81625007,81870860,31921003)。
Amyloid-beta(Aβ)plays a pivotal role in the pathogenesis of Alzheimer's disease(AD)and has been regarded as the main therapeutic target for AD.However,most of the Aβ-targeted clinical trials have not succeeded.There...
关键词：Alzheimer's disease amyloidβ immunotherapy Β-SECRETASE Γ-SECRETASE enzyme inhibitor multi-target therapy tertiary prevention strategy 
Physalin B reduce secretion of Aβ by inhibiting phosphorylation of STAT3 via down-regulated expression of β-secretase and γ-secretase
《中国药理学与毒理学杂志》2019年第6期426-427,共2页BAI Shan-shan ZHUO Lin SUN Yi SHI Ru-ling XIE Yong-sheng ZHANG Wei 
National Natural Science Foundation(U1604108);Key Science and Technology Program of Henan Province(152102310112; 162102310121);National Training Program of Innovation for Undergraduates(201710472009)
OBJECTIVE Extracellular amyloid-β(Aβ) plaques are one of the major pathological hallmarks of Alzheimer disease(AD). Therefore, decreasing Aβ levels is one strategyfor preventing the etiology of AD. Aβ peptides are...
关键词：Alzheimer disease PHYSALIN B Β-AMYLOID protein BACE1 PS1 STAT3 
Amyloid precursor-like protein 2 C-terminal fragments upregulate S100A9 gene and protein expression in BV2 cells
《Neural Regeneration Research》2014年第21期1923-1928,共6页Guangzhe Li Hui Chen Lin Cheng Rongjie Zhao Junchang Zhao Yanji Xu 
supported by the Natural Science Foundation of Technology Gallery in Jilin Province of China,No.2011-15237;the National Natural Science Foundation of China,No.81160159
The murine microglial cell line BV2 has neuroprotective effects, but is toxic to neurons by secret-ing inlfammatory cytokines, and is an important target in the treatment of nerve inlfammation and neurodegenerative di...
关键词：nerve regeneration NEURODEGENERATION Alzheimer’s disease APLP2 S100A9 C-terminal fragments amyloid precursor protein BV2 cells Γ-SECRETASE NSFC grant neural regeneration 
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