Γ-SECRETASE

作品数：23被引量：59H指数：5
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相关领域：医药卫生更多>>
相关作者：殷莹曹鹏缪凤琴于春泳梁国标更多>>
相关机构：东南大学清华大学第二军医大学台湾大学更多>>
相关期刊：《National Science Review》《Advances in Bioscience and Biotechnology》《Acta Biochimica et Biophysica Sinica》《Medicinal Plant》更多>>
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Defining the minimum substrate and charge recognition model of gamma-secretase
《Acta Pharmacologica Sinica》2017年第10期1412-1424,共13页Yan YAN Ting-Hai XU Karsten MELCHER H Eric XU 
γ-Secretase is an intramembrane aspartyl protease that cleaves the C99 fragment of amyloid precursor protein to generate extracellular Aβ peptides. These peptides can oligomerize and aggregate to form amyloid plaque...
关键词：Alzheimer＇s disease amyloid beta （Aβ） amyloid precursor protein （APP） C99  γ-secretase minimum substrate Notchprotein recognition model 
Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice被引量：1
《Acta Biochimica et Biophysica Sinica》2015年第4期258-266,共9页Yanan Chu Xuehua Peng Zhiming Long Kejian Wang Shifang Luo Akhilesh Sharma Guiqiong He 
This work was supported by the grants from the National Natural Science Foundation of China （Nos. 81371221 and 30700885） and the Program for New Century Excellent Talents in University （No. NCET-11-1084）.
The γ-secretase complex catalyzes the final cleavage step of amyloid β-protein precursor （APP） to generate amyloid β （Aβ） peptide, a pathogenic component of senile plaques in the brain of AIzhei- mer＇s disea...
关键词：presenilin enhancer-2 Γ-SECRETASE Alzheimer＇s disease central nervous system DISTRIBUTION 
The cryo-electron microscopy structure of γ-secretase: towards complex assembly, substrate recognition and a catalytic mechanism
《National Science Review》2015年第1期4-5,共2页Yanyong Kang Karsten Melcher H.Eric Xu 
Alzheimer’s disease(AD)is the most common form of neurodegenerative disorder to cause dementia in the elderly.It afects millions of people worldwide and puts tremendous emotional and economic burden on afected famili...
关键词：The cryo-electron microscopy structure of towards complex assembly substrate recognition and a catalytic mechanism SECRETASE 
γ-Secretase inhibitor DAPT sensitizes t-AUCB-induced apoptosis of human glioblastoma cells in vitro via blocking the p38 MAPK/MAPKAPK2/Hsp27 pathway
《Acta Pharmacologica Sinica》2014年第6期825-831,共7页Jun-yang LI Ru-jun LI Han-dong WANG 
Acknowledgements We thank Prof Bruce D HAMMOCK for providing the sEH inhibitor t-AUCB. This study was supported by the National Natural Science Foundation of China （No 81070974 and No 81301905）.
Aim： Trans-4-[4-（3-adamantan-1-yl-ureido）-cyclohexyloxy]-benzoic acid （t-AUCB） is a soluble epoxide hydrolase inhibitor that suppresses glioblastoma cell growth in vitro. The aim of this study was to examine whet...
关键词：GLIOMA chemotherapy Γ-SECRETASE DAPT soluble epoxide hydrolase t-AUCB apoptosis caspase-3 p38 MAPK MAPKAPK2 HSP27 
γ-secretase inhibitor DAPT prevents neuronal death and memory impairment in sepsis associated encephalopathy in septic rats被引量：14
《Chinese Medical Journal》2014年第5期924-928,共5页Huang Man Liu chunhui Hu Yueyu Wang Pengfei Ding Meiping 
Background Brain dysfunction is a frequent complication of sepsis,usually defined as sepsis-associated encephalopathy （SAE）.Although the Notch signaling pathway has been proven to be involved in both ischemia and ne...
关键词：DAPT Γ-SECRETASE memory impairment SEPSIS NOTCH 
β-Arrestinl regulates γ-secretase complex assembly and modulates amyloid-β pathology被引量：1
《Cell Research》2013年第3期351-365,共15页Xiaosong Liu Xiaohui Zhao Xianglu Zeng Koen Bossers Dick F Swaab Jian Zhao Gang Pei 
Alzheimer＇s disease （AD） is a progressive and complex neurodegenerative disease in which the γ-secretase- mediated amyloid-β （Aβ） pathology plays an important role. We found that a multifunctional protein, β-...
关键词：Alzheimer＇s disease β-arrestinl APH- 1 Γ-SECRETASE 
The Achilles heel of γ-secretase： can we contain Alzheimer＇s disease by reducing synthesis of β-amyloid？
《Acta Pharmacologica Sinica》2010年第11期1407-1408,共2页Alexei VERKHRATSKY 
Alzheimer＇s disease is the ultimate .scourge of mankind that haunts the ageing population and increas- ingly becomes the major health and social problem faced by our society. Alzheimer＇s disease （AD）, described b...
Effects of chronic cerebral hypoperfusion of beta- and gamma-secretase on learning and memory in rats
《Neural Regeneration Research》2010年第5期353-357,共5页Xiaojuan Wang Hong Liu Liang Li 
the Natural Science Foundation of Bei-jing, No. 7073088
BACKGROUND： Chronic cerebral hypoxia and ischemia have been shown to be related to occurrence of sporadic Alzheimer＇s disease, and β- and y-secretase play an important role in the generation of β-amyloid protein. ...
关键词：chronic cerebral hypoperfusion Β-AMYLOID Β-SECRETASE Γ-SECRETASE Alzheimer＇s disease brain injury neural regeneration 
A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis被引量：14
《Cell Research》2010年第2期138-153,共16页Lin Teng Jian Zhao Feifei Wang Lan Ma Gang Pei 
Supplementary information is linked to the online version of the paper on the Cell Research website.Acknowledgments We thank Dr David Westaway （University of Alberta） for TgCRND8 mice, Dr David Baltimore （California Institute of Technology） for lentiviral constructs, Dr Raphael Kopan （Washington University） for the plasmid of myc-tagged NotchAE and Dr Johan Lundkvist （Karolinska Institutet） for the plasmid of Gal4-driven luciferase reporter gene, the plasmid of APP/CTFI3-GVP and NAE-GVP. We appreciate Shunmei Xin, Shan Chen and Xianglu Zeng for their technical assistance. We thank all members of the lab for sharing reagents and advice. This research was supported by the Ministry of Science and Technology （2009ZX09103-684）, the National Natural Science Foundation of China （30621091, 30625014, 30623003, 30871285 and 90713047）, the Shanghai Municipal Commission for Science and Technology （07PJ14099 and 09JC1416400）, and the Chinese Academy of Sciences （2007KIP204）.
Dysregulation of β-site APP-cleaving enzyme （BACE） and/or γ-secretase leads to anomalous production of amyloid-β peptide （Aβ） and contributes to the etiology of Alzheimer＇s disease （AD）. Since these secreta...
关键词：G protein-coupled receptor Alzheimer＇s disease BACE Γ-SECRETASE Notch 
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