OSTEOPOROTIC

作品数：75被引量：344H指数：11
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相关领域：医药卫生更多>>
相关作者：吴子祥张波李建磊韩维奇蒋伟宇更多>>
相关机构：南方医科大学第三附属医院温州医科大学泗洪县人民医院成都军区总医院更多>>
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Metabolomics analysis of femoral tissue reveals the impact of Anemarrhenae Rhizoma on metabolic pathways in osteoporotic rats
《Journal of Chinese Pharmaceutical Sciences》2025年第2期135-149,共15页Yuxin Wen Qi Jiang Zhuang Huang Pengyu Chen Xing Hong Qiong Wang Tao Huang Lintao Han 
Foundation items:Wuhan Health Research Fund(Grant No.WZ21A06);National Natural Science Foundation of China(Grant No.81903815)。
This study aimed to assess the therapeutic potential of Anemarrhenae Rhizoma(AR)in osteoporotic rats and to elucidate the metabolic pathways involved in AR’s role in alleviating osteoporosis(OP).OP was induced in rat...
关键词：Anemarrhenae Rhizoma OSTEOPOROSIS RATS Metabolomics 
Biomaterials for surgical repair of osteoporotic bone defects
《Chinese Chemical Letters》2025年第1期92-98,共7页Xu Luo Jinwen Xiao Qiming Yang Xiaolong Lu Qianjun Huang Xiaojun Ai Bo Li Li Sun Long Chen 
supported by the National Natural Science Foundation of China(Nos.82160419 and 82302772);Guizhou Basic Research Project(No.ZK[2023]General 201)。
As the global population ages,osteoporotic bone fractures leading to bone defects are increasingly becoming a significant challenge in the field of public health.Treating this disease faces many challenges,especially ...
关键词：Osteoporotic bone defect BIOMATERIALS NANOMATERIALS Bone tissue engineering Bone regeneration 
Bone improvement in osteoporotic rabbits using CoCrMo implants
《Engineered Regeneration》2024年第4期495-504,共10页Jesica I.Zuchuat Adriana S.Manzano Valeria Sigot Gaston L.Mino Oscar A.Decco 
support from the Universidad Nacional de Entre Rios(UNER)through the PID 6221 and PID 6320;research grant from the Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET).
The management of bone repair in patients with osteoporosis depends on the clinical situation and the extent of the damage.The repair of bone lesions by inducing new bone formation is important for maintaining bone ar...
关键词：OSTEOPOROSIS Bone formation Bone repair Tissue engineering CoCrMo alloy 
Composite demineralized bone matrix nanofiber scaffolds with hierarchical interconnected networks via eruptive inorganic catalytic decomposition for osteoporotic bone regeneration
《Journal of Materials Science & Technology》2024年第32期246-259,共14页Sung Won Ko Joshua Lee Ji Yeon Lee Jeong Hwi Cho Sunny Lee Hak Su Jang Chan Hee Park Hyun Jin Tae Cheol Sang Kim Young Min Oh 
supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Korean government(MSIT)(Project No.2016R1C1B2008296);It was also partially supported by the Na-tional Research Foundation of Korea(NRF)grant funded by the Korean Ministry of Education(Nos.NRF-2021R1I1A1A01047751 and RS-2023-00240020).
Demineralized bone matrix(DBM)is one of the standard biomaterials used to fill surgical bone defects in general orthopedic procedures.However,current DBM products come in the form of powder or viscous solutions that f...
关键词：Demineralized bone matrix Hierarchical networks Catalytic decomposition Bone regeneration 
Augmenting osteoporotic bone regeneration through a hydrogel-based rejuvenating microenvironment
《Bioactive Materials》2024年第11期440-454,共15页Xiaoting Zhang Boguang Yang Lu Feng Xiayi Xu Chenmin Wang Yuk-wai Lee Ming Wang Xuan Lu Ling Qin Sien Lin Liming Bian Gang Li 
National Natural Science Foundation of China(82172430 and 82272505);University Grants Committee,Research Grants Council of the Hong Kong Special Administrative Region,China(14113723,14108720,14121721,14202920,N_CUHK472/22,C7030-18G,T13-402/17-N and AoE/M-402/20);Heath and Medical Research Fund(HMRF)Hong Kong(17180831,08190416 and 09203436);Hong Kong Innovation Technology Commission Funds(PRP/050/19FX),CUHK direct grant(2022.042).
Osteoporotic bone defects pose a significant challenge for bone regeneration as they exhibit impaired healing capacity and delayed healing period.To address this issue,this study introduces a hydrogel that creates a r...
关键词：Osteoporotic bone defects Bone regeneration Rejuvenating microenvironment SECRETOME Focal adhesion pathway 
Biodegradable Zn-2Cu-0.5Zr alloy promotes the bone repair of senile osteoporotic fractures via the immune-modulation of macrophages
《Bioactive Materials》2024年第8期422-437,共16页Huanzhong Ji Gang Shen Hanghang Liu Yao Liu Junyu Qian GuoJiang Wan En Luo 
supported by Grants from the National Natural Science Foundation of China(82370932);Research and Develop Program,West China Hospital of Stomatology Sichuan University(RD-03-202102);Program of Science and Technology Department of Sichuan Province(2023ZYD0107).The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article.
Delayed bone-healing of senile osteoporotic fractures remains a clinical challenge due to the alterations caused by aging in bone and immune systems.The novel biomaterials that address the deficiencies in both skeleta...
关键词：Zinc-based biodegradable metals Macrophage Bone regeneration Immune-osteo microenvironment Senile osteoporotic bone fracture healing 
Autocatalytic bifunctional supramolecular hydrogels for osteoporotic bone repair
《National Science Review》2024年第7期257-272,共16页Zhihui Han Xiang Gao Yuanjie Wang Cheng Huang Hao Song Shuning Cheng Xiaoyuan Yang Xiaoliang Cui Jie Wu Kailu Wei Liang Cheng 
partially supported by the National Key R&D Program of China(2022YFB3804600 and 2021YFF0701800);the National Natural Science Foundation of China(U20A20254 and 52072253);the Collaborative Innovation Center of Suzhou Nano Science and Technology,Suzhou Key Laboratory of Nanotechnology and Biomedicine,the Jiangsu Natural Science Fund for Distinguished Young Scholars(BK20211544);the Jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices,Soochow University(KJS2212);the Overseas Expertise Introduction Project for Discipline Innovation(111 Project);the Joint International Research Laboratory of Carbon-Based Functional Materials and Devices,Suzhou Key Laboratory of Nanotechnology and Biomedicine,and the Key Laboratory of Structural Deformities in Children of Suzhou(SZS2022018).
Conventional bone scaffolds,which are mainly ascribed to highly active osteoclasts and an inflammatory microenvironment with high levels of reactive oxygen species and pro-inflammatory factors,barely satisfy osteoporo...
关键词：AUTOCATALYSIS supramolecular hydrogel ANTI-INFLAMMATION osteoporosis bone defect 
PFNA2 versus 95 Degree Condylar Blade Plate in the Management of Unstable Trochanteric Fractures
《Open Journal of Orthopedics》2024年第2期93-104,共12页Piyush Gadegone Wasudeo Gadegone Vijayanand Lokhande Virender Kadian 
Purpose: The proximal femoral nail anti-rotation (PFNA) is known to have advantages in enhancing the anchorage ability of internal fixation in elderly unstable osteoporotic intertrochanteric fracture patients. However...
关键词：Proximal Femoral Nail Anti-Rotation Condylar Blade Plate Internal Fixation Unstable Intertrochanteric Fracture OSTEOPOROTIC 
Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization
《Bone Research》2023年第4期860-875,共16页Guanyue Su Demao Zhang Tiantian Li Tong Pei Jie Yang Shasha Tu Sijun Liu Jie Ren Yaojia Zhang Mengmeng Duan Xinrui Yang Yang Shen Chenchen Zhou Jing Xie Xiaoheng Liu 
supported by the National Natural Science Foundation of China (Grant numbers 11932014 and 31971239);the Sichuan Science and Technology Program (Grant numbers 2022NSFSC0765 and 2022ZYD0079)。
Matrix vesicles(MVs)have shown strong effects in diseases such as vascular ectopic calcification and pathological calcified osteoarthritis and in wound repair of the skeletal system due to their membranous vesicle cha...
关键词：protective WOUND MATRIX 
Autophagy mediates osteoporotic bone regeneration induced by micro-/nano-structured modification on hydroxyapatite bioceramics
《Engineered Regeneration》2023年第3期245-256,共12页Jinjie Cui Xinran Zhang Liming Cheng Kaili Lin 
support from the National Natural Science Foundation of China (82072396,32271379);Science and Technology Commission of Shanghai Municipality (21490711700);the Interdisciplinary Program of Shanghai Jiao Tong University (YG2021ZD12).
Osteoporosis(OP)is an age-related disease of bone metabolism,characterized by bone mass loss and bone mi-croarchitecture deterioration,the poor osteogenesis microenvironment of OP caused hardly repairing of the bone d...
关键词：Osteoporosis Osteogenesis AUTOPHAGY HYDROXYAPATITE Micro-/nano-structured modification 
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