IMMUNODEFICIENCY

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Relation between dysbiosis and inborn errors of immunity
《World Journal of Methodology》2024年第4期104-109,共6页Öner Özdemir 
Inborn errors of immunity(IEI)disorders,formerly primary immune deficiency diseases,are a heterogeneous group of disorders with variable hereditary transitions,clinical manifestations,complications and varying disease...
关键词：IMMUNODEFICIENCY MICROBIOME MICROBIOTA Fecal microbiota transplantation IMMUNOGLOBULIN 
A duplex TaqMan probe-based real-time PCR method for rapid detection and differentiation of the classical and VB strains of human immunodeficiency virus
《Science China(Life Sciences)》2024年第1期208-210,共3页Aiping Wang Haili Wang Jianguo Zhao Yumei Chen Hongliang Liu Peiyang Ding Yan Niu Gaiping Zhang 
This work was supported by the COVID-19 Emergency Project of the National Key Research and Development Program of China(2022YFC0867900);the National Natural Science Foundation of China(32072944);the Emergency Scientific Research on Epidemic Prevention and Control of Henan Province(211100310200);Science and Technology Project of Henan Province(21210230180);Medical Science and Technology project of Henan Province(LHGJ20210274).
Dear Editor,Human immunodeficiency virus(HIV)is a lentivirus that,if left untreated,can lead to acquired immunodeficiency syndrome(AIDS).The virus can be divided into two types based on genetic differences:HIV-1 and H...
关键词：IMMUNODEFICIENCY UNTREATED 
Author Correction:Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24
《Cellular & Molecular Immunology》2024年第1期100-100,共1页Zhengzhou Ying Swanand Hardikar Joshua B.Plummer Tewfik Hamidi Bin Liu Yueping Chen Jianjun Shen Yunxiang Mu Kevin M.McBride Taiping Chen 
In the sentence beginning‘To trace cell proliferation,FO and MZ B cells’and the sentence beginning‘For cell activation,naïve B cells or CH12F3 cells’in this article,the[10 ng/ml]‘F(ab’)_(2)fragment goat anti-mou...
关键词：IMMUNODEFICIENCY CD19 DEFICIENT 
Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24
《Cellular & Molecular Immunology》2023年第12期1487-1498,共12页Zhengzhou Ying Swanand Hardikar Joshua B.Plummer Tewfik Hamidi Bin Liu Yueping Chen Jianjun Shen Yunxiang Mu Kevin M.McBride Taiping Chen 
supported by a grant(1R01AI12140301A1)from the National Institutes of Health(NIH)in the USA.
Immunodeficiency,centromeric instability,and facial anomalies(ICF)syndrome is a rare autosomal recessive disorder characterized by DNA hypomethylation and antibody deficiency.It is caused by mutations in DNMT3B,ZBTB24...
关键词：ICF syndrome ZBTB24 CD19 IL-5Ra HYPOGAMMAGLOBULINEMIA 
Virome in immunodeficiency:what we know currently
《Chinese Medical Journal》2023年第22期2647-2657,共11页Hu Wang Siqi Xu Shuang Li Bin Su Scott Sherrill-Mix Guanxiang Liang 
supported by grants from the Start-up Foundation of Tsinghua University(No.400-53332101822);the Tsinghua-Peking Center for Life Sciences(No.045-61000100122);the National Key R&D Program of China(Nos.2021YFC2301900 and 2021YFC2301905);the National Natural Science Foundation of China(Nos.32200036 and 81974303);the Beijing Natural Science Foundation(Nos.L222068 and Z220018);the High-Level Public Health Specialized Talents Project of Beijing Municipal Health Commission(No.2022-2-018);the Beijing Key Laboratory for HIV/AIDS Research(No.BZ0089)
Over the past few years,the human virome and its complex interactions with microbial communities and the immune system have gained recognition as a crucial factor in human health.Individuals with compromised immune fu...
关键词：Human virome IMMUNODEFICIENCY People living with HIV PLWH DIAGNOSIS THERAPEUTICS Autoimmune diseases Organ transplantation 
Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing
《Signal Transduction and Targeted Therapy》2023年第10期4825-4837,共13页Xiao Zheng Chunhui Huang Yingqi Lin Bofeng Han Yizhi Chen Caijuan Li Jiawei Li Yongyan Ding Xichen Song Wei Wang Weien Liang Jianhao Wu Jiaxi Wu Jiale Gao Chengxi Wei Xudong Zhang Zhuchi Tu Sen Yan 
This work was supported by the National Key Research and Development Program of China(2021YFA0805300,2021YFA0805204);the National Natural Science Foundation of China(82171244,81922026,32170981);Guangzhou Key Research Program on Brain Science(202007030008).
Severe combined immunodeficiency(SCiD)encompasses a range of inherited disorders that lead to a profound deterioration of the immune system.Among the pivotal genes associated with SCID,RAG1 and IL2RG play crucial role...
关键词：IMMUNODEFICIENCY IMMUNITY RAG1 
Disrupted Ca^(2+) h homeostasis and immunodeficiency in patients with functional IP_(3) receptor subtype 3 defects被引量：1
《Cellular & Molecular Immunology》2023年第1期11-25,共15页Julika Neumann Erika Van Nieuwenhove Lara E.Terry Frederik Staels Taylor R.Knebel Kirsten Welkenhuyzen Kourosh Ahmadzadeh Mariah R.Baker Margaux Gerbaux Mathijs Willemsen John S.Barber Irina I.Serysheva Liesbeth De Waele François Vermeulen Susan Schlenner Isabelle Meyts David IYule Geert Bultynck Rik Schrijvers Stephanie Humblet-Baron Adrian Liston 
supported by the VIB Grand Challenges Program,the KU Leuven C1 program,the European Union’s Horizon 2020 research and innovation program under grant agreement No 779295(to AL);the Biotechnology and Biological Sciences Research Council(BBSRC)through Institute Strategic Program Grant funding BBS/E/B/000C0427 and BBS/E/B/000C0428 and the KU Leuven BOFZAP start-up grant(to SH-B);Work in the Bultynck team was supported by grants from the Research Council of the KU Leuven(C14/19/99 and AKUL/19/34);Research Foundation-Flanders(G.0818.21N;G.0945.22N);DIY is supported by the National Institutes of Health(NIH)R01-DE0014756 grant.MRB and IIS are supported by the NIH R01GM072804 grant(to IIS);the Welch Foundation Research Grant AU-2014-20190331(to IIS);the American Heart Association grant 18CDA34110086(to MRB);IIS,DIY,and GB are in the FWO Scientific Research Network CaSign(W0.019.17N);IM and RS are FWO senior clinical investigator fellows.IM and RS are members of the European Reference Network for Rare Immunodeficiency,Autoinflammatory and Autoimmune Diseases(project ID No.739543).
Calcium signaling is essential for lymphocyte activation, with genetic disruptions of store-operated calcium (Ca^(2+)) entry resulting in severe immunodeficiency. The inositol 1,4,5-trisphosphate receptor (IP_(3)R), a...
关键词：Primary immunodeficiency Calcium signalling Whole exome sequencing 
Author Correction: Disrupted Ca2+ homeostasis and immunodeficiency in patients with functional IP3 receptor subtype 3 defects
《Cellular & Molecular Immunology》2023年第1期114-114,共1页Julika Neumann Erika Van Nieuwenhove Lara E.Terry Frederik Staels Taylor R.Knebel Kirsten Welkenhuyzen Kourosh Ahmadzadeh Mariah R.Baker Margaux Gerbaux Mathijs Willemsen John S.Barber Irina I.Serysheva Liesbeth De Waele François Vermeulen Susan Schlenner Isabelle Meyts David I.Yule Geert Bultynck Rik Schrijvers Stephanie Humblet-Baron Adrian Liston 
In this article the statement in the Acknowledgements section was incorrectly given as “MRB and IIS are supported by the NIH R01GM080139 grant (to IIS), the Welch Foundation Research Grant AU-2014-20190331 (to IIS), ...
关键词：IIS STATEMENT knowledge 
Lentiviral Gene Therapy for Artemis-Deficient SCID
《四川生理科学杂志》2022年第12期2107-2107,共1页Morton J Cowan 
Background:The DNA-repair enzyme Artemis is essential for rearrangement of T-and B-cell receptors.Mutations in DCLRE1C,which encodes Artemis,cause Artemis-deficient severe combined immunodeficiency(ART-SCID),which is ...
关键词：SCID IMMUNODEFICIENCY ARTEMIS 
SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism被引量：1
《Signal Transduction and Targeted Therapy》2021年第10期3119-3131,共13页Yukai Jing Li Luo Ying Chen Lisa S.Westerberg Peng Zhou Zhiping Xu Andres A.Herrada Chan-Sik Park Masato Kubo Heng Mei Yu Hu Pamela Pui-Wah Lee Bing Zheng Zhiwei Sui Wei Xiao Quan Gong Zhongxin Lu Chaohong Liu 
supported by the National Natural Science Foundation of China(31970839);the National Key R&D Program of China(1316203);Independent Innovation Research Fund of Huazhong University of Science and Technology(2020kfyXGYJ017);the HUST Academic Frontier Youth Team(2018QYTD10).
The SARS-CoV-2 infection causes severe immune disruption.However,it is unclear if disrupted immune regulation still exists and pertains in recovered COVID-19 patients.In our study,we have characterized the immunephe n...
关键词：PATIENTS METABOLISM CD19 
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