supported by the National Natural Science Foundation of China(Grant Nos.32070663,32125009,and 62172325);the National Key R&D Program of China(Grant No.2022YFC3400300);the Fundamental Research Funds for the Central Universities,China(Grant No.xzy012020012);the Natural Science Basic Research Program of Shaanxi,China(Grant No.2021GXLH-Z-098)to Kai Ye and Xaiofei Yang.
Microsatellite instability(MSI)is an indispensable biomarker in cancer immunotherapy.Currently,MSI scoring methods by high-throughput omics methods have gained popularity and demonstrated better performance than the g...
Acute leukemia is an aggressive disease that has high mortality rates worldwide.The error rate can be as high as 40%when classifying acute leukemia into its subtypes.So,there is an urgent need to support hematologists...
Classification of gene expression data is a pivotal research area that plays a substantial role in diagnosis and prediction of diseases. Generally, feature selection is one of the extensively used techniques in data m...
This work is partially supported by NIH/NIAID grant RO1 AI087135;CAA is supported by NIH/NIAID grant K24 AI114818.
Bordetella pertussis(B.pertussis)is the causative agent of pertussis,also referenced as whooping cough.Although pertussis has been appropriately controlled by routine immunization of infants,it has experienced a resur...
The objective of this project was to search for consensus in differential gene expression data and in regulation of differentially expressed genes among DNA microarray studies of atherosclerotic vessels and plaque. Se...
Micro array technologies have become a widespread research technique for biomedical researchers to assess tens of thousands of gene expression values simul- taneously in a single experiment. Micro array data analysis ...
Background Clustering is a useful exploratory technique for interpreting gene expression data to reveal groups of genes sharing common functional attributes. Biologists frequently face the problem of choosing an appro...
supported by the National Natural Science Foundation of China (20835002);International Science and Technology Cooperation Program of the Ministry of Science and Technology (MOST) of China (2008DFA32250)
The classification of cancer is a major research topic in bioinformatics. The nature of high dimensionality and small size associated with gene expression data,however,makes the classification quite challenging. Altho...
Analysis of gene expression data can help to find the time-lagged co-regulation of gene cluster. However, existing method just solve the problem under the condition when the data is discrete number. In this paper, we ...
A new method for analysis of microarray gene expression experiments referred to as Sum-based Meta-analytical Enrichment?(SME) is proposed in this manuscript. SME is a combined enrichment and meta-analytical approach t...