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EPITOPES: 作品数：96被引量：141H指数：7; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：郭礼和费俭夏国宏邢力叶欣更多>>; 相关机构：中国科学院上海生命科学研究院郑州大学南昌大学广州血液中心更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金World Health Organization国家重点基础研究发展计划中国博士后科学基金更多>>

Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1: 《hLife》2024年第10期527-541,共15页Qi Pan Xiaomin Xing Jianhai Yu Qiang Chen Haizhan Jiao Wanqin Zhang Yingfen Wen Ming Gao Wei Zhao Lei Yu Hongli Hu; supported by grants from the National Natural Science Foundation of China(81971924 to L.Y.and 32370146 to W.Z.);Guangzhou Municipal Science and Technology Bureau(2023A03J0791 to L.Y.);Guangdong Science and Technology Program(2021B1212030014 to W.Z.);Guangdong Basic and Applied Basic Research Fund Enterprise Joint Fund(2021A1515220017 to W.Z.);Medical Scientific Research Foundation of Guangdong Province(B2022112 to J.Y.),Shenzhen Science and Technology Innovation Committee(JCYJ20210324131802008 to H.H.);Ganghong Young Scholar Development Fund(to H.H.);the Shenzhen-Hong Kong Cooperation Zone for Technology and Innovation(HZQB-KCZYB-2020056 to H.H.);the Kobilka Institute of Innovative Drug Discovery and Presidential Fellowship and University Development Fund at the Chinese University of Hong Kong,Shenzhen(to H.H.,H.J.,and Q.C.);Presidential Fellowship at the Chinese University of Hong Kong,Shenzhen(to Q.P.and W.Z.)。; Antibodies targeting non-structural protein 1(NS1)confer protection against Zika virus(ZIKV).Although monoclonal an-tibodies(MAbs)3G2 and 4B8 are more potent than MAb 4F10 in suppressing ZIKV infection in neonatal mic...; 关键词：Zika virus(ZIKV) non-structural protein 1(NS1) monoclonal antibodies(MAbs) EPITOPES

Neutralization of SARS-CoV-2 infection by antibodies targeting diverse epitopes: 《Genes & Diseases》2024年第4期134-137,共4页Shusheng Wang Yunji Liao Kaiyong Yang Hang Ma Zhangyi Song Haiqiu Huang Li Zhang Ailing Wang Lei Han Jiawei Zhang Hui Chen Haiyang Yin Yantin Bian Hua Jiang Xiaodong Xiao Yueqing Xie Yunsheng Yuan Jianwei Zhu; the National Natural Science Foundation of China(No.81773621,82073751 to JZ);the National Science and Technology Major Project"Key New Drug Creation and Manufacturing Program"of China(No.2019ZX09732001-019 to JZ);the Key R&D Supporting Program(Special support for developing medicine for infectious diseases)from the Administration of Chinese and Singapore Tianjin Eco-city to Jecho Biopharmaceuticals Ltd.Co.,Zhejiang University special CoVID-19 grant 2020XGZX099;Shanghai Jiao Tong University"Crossing Medical and Engineering"grant 20X190020003 to JZ.; The CoVID-19 pandemic that started in late 2019 is sweeping through the world,posing historic challenges to global health,and disrupting social and economic lives.Previous and recent studies indicate that monoclonal a...; 关键词：ANTIBODIES inhibited MONOCLONAL

SARS-CoV-2 peptides/epitopes for specific and sensitive diagnosis: 《Cellular & Molecular Immunology》2023年第5期540-542,共3页He-Wei Jiang Yang Li Sheng-Ce Tao; the National Key Research and Development Program of China Grant(No.2020YFE0202200);the National Natural Science Foundation of China(Nos.31900112 and 31970130).; The COVID-19 pandemic,caused by SARS-CoV-2,has presented an unprecedented challenge to global public health.The rapid,reliable,and affordable diagnosis of COVID-19 is essential for controlling the spread of the acute ...; 关键词：DIAGNOSIS app false

An antibody cocktail with broadened mutational resistance and effective protection against SARS-CoV-2: 《Science China(Life Sciences)》2023年第1期165-179,共15页Chunyun Sun Hang Chi Fei Yuan Jing Li Ji Yang Aihua Zheng Fei Wang Lingling Sun Yanjing Zhang Ping Hu Lihua Jiao Yongqiang Deng Liangzhi Xie; supported by the National Key Research and Development Project of China(2021YEF0201700)。; Neutralizing antibodies have been proven to be highly effective in treating mild and moderate COVID-19 patients,but continuous emergence of SARS-CoV-2 variants poses significant challenges.Antibody cocktail treatments...; 关键词：SARS-CoV-2 COVID-19 EPITOPES antibody cocktail mutational escape

History,epidemiology,vaccine and transmission of coronavirus disease 2019 (COVID-19):a quick review: 《Life Research》2021年第3期9-19,共11页Rabia Altaf Asra Iftikhar Rabia Haq Bushra Zahoor Muhammad Zaini Asmawi Mohamed Khadeer Ahamed Basheer; Coronavirus belonging to family Coronaviridae is a large group of viruses causing respiratory and gastrointestinal diseases.The outbreak of 2019-novel coronavirus has created panic in the whole world after being trans...; 关键词：PANDEMIC Severe acute respiratory syndrome coronavirus-2 Social distance Respiratory illness EPITOPES S-glycoprotein

Peptides-based vaccine against SARS-nCoV-2 antigenic fragmented synthetic epitopes recognized by T cell and β-cell initiation of specific antibodies tofightthe infection: 《Bio-Design and Manufacturing》2021年第3期490-505,共16页Zainularifeen Abduljaleel Faisal A.Al-Allaf Syed A.Aziz; The World Health Organization has declared the rapidly spreading coronavirus to be a global pandemic.The FDA is yet to approve a vaccine for human novel coronavirus.Here,we developed a peptide-based vaccine and used h...; 关键词：COVID-19 SARS-nCoV-2 Peptide-based vaccine Cell-penetrating peptides Lipid membrane Vaccine efficacy

Potential epitopes and mutation characteristics of 2019 novel coronavirus spike protein: 《China Medical Abstracts(Internal Medicine)》2021年第1期23-24,共2页LI Hu; Objective To predict the epitopes of the spike protein of 2019 novel coronavirus(2019-nCoV)and to analyze the mutation characteristics of this protein.Methods The gene sequences of 2019-nCoV was downloaded from GenBan...; 关键词：CHARACTERISTICS IMMUNE SPIKE

Flu Universal Vaccines: New Tricks on an Old Virus被引量：1: 《Virologica Sinica》2021年第1期13-24,共12页Ruikun Du Qinghua Cui Lijun Rong; supported by The Drug Innovation Major Project(Grant No.2018ZX09711001);the Key Research and Development Projects of Science and Technology Department of Shandong Province(Grant No.2017CXGC1309);Shandong Provincial Natural Science Foundation of China(Grant No.ZR2019MH078,ZR2017MH086); Conventional influenza vaccines are based on predicting the circulating viruses year by year,conferring limited effectiveness since the antigenicity of vaccine strains does not always match the circulating viruses.Thi...; 关键词：Influenza virus Universal vaccine Conserved epitopes Broadly protection

Human Monoclonal Antibodies: On the Menu of Targeted Therapeutics Against COVID-19被引量：1: 《Virologica Sinica》2020年第6期713-724,共12页Junsen Chen Rui Huang Yiwen Nie Xinyue Wen Ying Wu; supported by Grants from the National Science and Technology Major Project (Grant No.2018ZX10733403)。; Coronavirus disease 2019(COVID-19), reminiscent of the severe acute respiratory syndrome(SARS) outbreak in 2003,has been a tragic disaster to people all over the world. As there is no specific drug for COVID-19, neutr...; 关键词：COVID-19 MABS S glycoprotein EPITOPES

Structural biology oriented predicative analysis of immunogenic epitopes on SARS-CoV-2 viral sequence by variable algorithms: 《Asian Pacific Journal of Tropical Medicine》2020年第6期283-284,共2页Dhanasekaran Sivaraman; Epitopes are small segmented antigenic peptides that are able to elicit the immune response by recognizing B and T-cells.In the present scenario,knowledge of immunogenic epitopes specific to severe acute respiratory s...; 关键词：ACUTE VACCINE RESPIRATORY

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