EPITOPES

作品数：96被引量：141H指数：7
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相关机构：中国科学院上海生命科学研究院郑州大学南昌大学广州血液中心更多>>
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Nonconserved epitopes dominate reverse preexisting T cell immunity in COVID-19 convalescents
《Signal Transduction and Targeted Therapy》2024年第7期2984-2998,共15页Xin Wang Jie Zhang Maoshun Liu Yuanyuan Guo Peipei Guo Xiaonan Yang Bingli Shang Min Li Jinmin Tian Ting Zhang Xi Wang Ronghua Jin Jikun Zhou George F.Gao Jun Liu 
supported by the National Key Research and Development Program of China(2022YFC2604100 to J.L.,and 2023YFC2306003 to X.W.);the National Natural Science Foundation of China(grants 92269203).
The herd immunity against SARS-CoV-2 is continuously consolidated across the world during the ongoing pandemic.However,the potential function of the nonconserved epitopes in the reverse preexisting cross-reactivity in...
关键词：IMMUNITY CONSERVED assessed 
A novel method for identifying SARS-CoV-2 infection mutants via an epitope-specific CD8^(+)T cell test
《Biosafety and Health》2024年第3期143-152,共10页Congling Qiu Bo Peng Chanchan Xiao Pengfei Chen Lipeng Mao Xiaolu Shi Zhen Zhang Ziquan Lv Qiuying Lv Xiaomin Zhang Jiaxin Li Yanhao Huang Qinghua Hu Guobing Chen Xuan Zou Xiaofeng Liang 
the Key Project of Shenzhen Science and Technology Innovation Commission(JCYJ20210324115411030);Natural Science Foundation of China(92169102);R&D Program of Guangzhou Laboratory(SRPG22-006);Sanming Project of Medicine in Shenzhen(SZSM202211023);GuangDong Basic and Applied Basic Research Foundation(2022B1515120043);the Open Project Fund of Guangdong Provincial People’s Hospital(YKY-KF202208);National Natural Science Foundation of China(81902097);Funding by Science and Technology Projects in Guangzhou(SL2023A04J01160);the Guangdong Basic and;Applied Basic Research Foundation(2023A1515140117);the fellowship of China Postdoctoral Science Foundation(2023TQ0136,2023M741379);supported by grants from the National Key Research and Development Plan(2023YFE0118700,2021YFC2301604);the Fundamental Research Funds for the Central Q4 Universities(21623406).
Since the outbreak of the coronavirus disease 2019(COVID-19)epidemic in 2019,the public health system has faced enormous challenges.Tracking the individuals who test positive for severe acute respiratory syndrome coro...
关键词：Asymptomatic coronavirus disease 2019 (COVID-19) EPITOPES Specific CD8^(+)T cell ELISPOT 
广州地区209例HLA-Ⅰ类抗体引起的血小板输注无效患者抗体特异性及epitopes分析被引量：4
《热带医学杂志》2022年第7期941-944,共4页陈扬凯 徐秀章 叶欣 邓晶 丁浩强 夏文杰 邵媛 刘静 陈大伟 许耀日 
广东省自然科学基金(2020A1515011348);广州市科技计划项目(201707010021);广州市医学重点学科建设项目(血液安全重点实验室)
目的了解广州地区人类白细胞抗原(HLA)⁃Ⅰ类抗体所致血小板输注无效(PTR)患者的HLA抗体特异性及高频抗原决定簇。方法采用ELISA方法对209例PTR患者的HLA⁃Ⅰ类抗体进行检测。运用Luminex检测平台,通过HLA特异性抗体检测试剂盒(LIFECODES ...
关键词：血小板输注无效 HLA-Ⅰ类抗体 抗原决定簇 
SARS-CoV-2 Epitopes following Infection and Vaccination Overlap Known Neutralizing Antibody Sites被引量：1
《Research》2022年第2期71-84,共14页Li Yang Te Liang Lane M.Pierson Hongye Wang Jesse K.Fletcher Shu Wang Duran Bao Lii Zhang Zhen Huang Wenshu Zheng Xiaomei Zhang Heewon Park Yuwen Li James E.Robinson Amy K.Fechan Christopher J.Lyon Jing Cao Lisa A.Morici Chenzhong Li Chad J.Roy Xiaobo Yu Tony Hu 
supported by the Department of Defense(grant number W8IxwH19i0926);National Institute of Allergy and Infectious Diseases contract(grant number_HHSN2722017000331);National Institute of Child Health and Human Development grant(grant numbers R01HD090927 and R01HDi03511);National Center for Research Resources and the Ofice of Research Infrastructure Programs(grant numbers OD011104).
Identification of epitopes targeted following virus infection or vaccination can guide vaccine design and development of therapeutic interventions targeting functional sites,but can be laborious.Herein,we employed pep...
关键词：vaccine ANTIBODY LIKELY 
Systematic profiling of SARS-CoV-2-specific IgG epitopes at amino acid resolution被引量：1
《Cellular & Molecular Immunology》2021年第4期1067-1069,共3页Huan Qi Ming-liang Ma He-wei Jiang Jian-ya Ling Ling-yun Chen Hai-nan Zhang Dan-yun Lai Yang Li Zi-wen Guo Chuan-sheng Hu Shu-juan Guo Qing-feng Meng Yan Ren Xiao Yang Wei Wang Jie Zhou Xiao-dong Zhao Hua Li Sheng-ce Tao 
partially supported by National Key Research and Developm ent Program of China Grant(No.2016YFA0500600);National Natural Science Foundation of China(Nos.31970130,31670831,31370813,and 31501054);Open Foundation of Key Laboratory of Systems Biomedicine(No.KLSB2020QN-05).
There is a worldwide pandemic of COVID-19 caused by SARS-CoV-2.1 By January 28,2021,more than 100 million cases had been diagnosed,and more than 2 million deaths had been reported(https://coronavirus.jhu.edu/map.html)...
关键词：map. PRECISE NEUTRAL 
COVID-19: cross-immunity of viral epitopes may influence severity of infection and immune response
《Signal Transduction and Targeted Therapy》2021年第4期1071-1072,共2页Junaid Kashir Khaled AlKattan Ahmed Yaqinuddin 
This work was supported by a COVID-19 project grant(#951)awarded by the Saudi Arabian Ministry of Health awarded to JK,KAK,and AY.
A recent study published in Science by Shrock et al.1 examined how responses to COVID-19 severity differed amongst patients with different prior viral exposure history,finding notable correlations between both.Such se...
关键词：SEVERITY IMMUNITY al. 
Mining of epitopes on spike protein of SARS-CoV-2 from COVID-19 patients被引量：6
《Cell Research》2020年第8期702-704,共3页Bao-zhong Zhang Ye-fan Hu Lin-lei Chen Thomas Yau Yi-gang Tong Jing-chu Hu Jian-piao Cai Kwok-Hung Chan Ying Dou Jian Deng Xiao-lei Wang Ivan Fan-Ngai Hung Kelvin Kai-Wang To Kwok Yung Yuen Jian-Dong Huang 
This work was supported by Health and Medical Research Fund(COVID190117)from the Government of the Hong Kong Special Administrative Region,the Shenzhen Peacock Team Project(KQTD2015033117210153);Shenzhen Science and Technology Innovation Committee Basic Science Research Grant(JCYJ20170413154523577);China Postdoctoral Science Foundation(2019M663167).
Dear Editor,The ongoing coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus-2(SARSCoV-2)is a serious threat to global public health,and is imposing severe burdens on huma...
关键词：ACUTE RESPIRATORY CLINICAL 
Targeting multiple epitopes on the spike protein:a new hope for COVID-19 antibody therapy
《Signal Transduction and Targeted Therapy》2020年第1期778-779,共2页Yeping Sun Bostjan Kobe Jianxun Qi 
supported by the Strategic Priority Research Program of CAS(XDB37030204);the National Key Research and Development Program of China(2016YFD0500305);the Zhejiang University Special Scientific Research Fund for COVID-19 Prevention and Control(2020XGZX031).
Lihong Liu et al.1 from Columbia University recently reported in Nature the isolation of a collection of 19 SARS-CoV-2-neutralizing monoclonal antibodies(mAbs)from five infected patients with high plasma virus-neutral...
关键词：al ANTIBODIES NEUTRAL 
Novel Immunogenic Epitopes in the NaPi-IIb Protein: Production of Monospecific Antibodies Using Synthetic Peptides Outlined on Isoform Specific Regions of the Type IIb Sodium-Dependent Phosphate Transporter (NaPi-IIb)
《Journal of Cancer Therapy》2016年第2期129-151,共23页Ângela Alice Amadeu Megale Jorge Mário da Costa Ferreira Júnior Letícia Batista Azevedo Rangel Maria Del Pilar Estevez Diz Max Senna Mano Paulo Marcelo Gehm Hoff Priscila Hess Lopes Roberto Jun Arai Wilmar Dias da Silva 
NaPi-IIb is a multiple passage protein membrane which is primarily responsible for phosphate uptake in the kidney and in the small intestine. Beyond its physiological functions, their involvement with carcinogenesis w...
关键词：NaPi2b Peptides ANTIBODIES Ovarian Cancer 
Computational analysis of antigenic epitopes of avian influenza A (H7N9) viruses被引量：6
《Science China(Life Sciences)》2015年第7期687-693,共7页LIU Mi SONG TingRui HUA Sha WU AiPing JIANG TaiJiao 
supported by the National Basic Research Program of China(2015CB910501);the Major National Earmark Project for Infectious Diseases(2014ZX10004002-001);the Key Research Program of the Chinese Academy of Sciences(KJZD-EW-L09-1-2)to Jiang Tai Jiao;the National Natural Science Foundation of China(31470273)to Wu Ai Ping
Influenza virus can rapidly change its antigenicity, via mutation in the hemagglutinin(HA) protein, to evade host immunity. The emergence of the novel human-infecting avian H7N9 virus in China has caused widespread co...
关键词：antigenic epitope antigenic evolution HEMAGGLUTININ influenza H7N9 virus 
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